FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604283208> ?p ?o ?g. }

• W2604283208 endingPage "174" @default.
• W2604283208 startingPage "162" @default.
• W2604283208 abstract "Ultraviolet (UV) radiation is a carcinogen that generates DNA lesions. Here, we demonstrate an unexpected role for DGCR8, an RNA binding protein that canonically functions with Drosha to mediate microRNA processing, in the repair of UV-induced DNA lesions. Treatment with UV induced phosphorylation on serine 153 (S153) of DGCR8 in both human and murine cells. S153 phosphorylation was critical for cellular resistance to UV, the removal of UV-induced DNA lesions, and the recovery of RNA synthesis after UV exposure but not for microRNA expression. The RNA-binding and Drosha-binding activities of DGCR8 were not critical for UV resistance. DGCR8 depletion was epistatic to defects in XPA, CSA, and CSB for UV sensitivity. DGCR8 physically interacted with CSB and RNA polymerase II. JNKs were involved in the UV-induced S153 phosphorylation. These findings suggest that UV-induced S153 phosphorylation mediates transcription-coupled nucleotide excision repair of UV-induced DNA lesions in a manner independent of microRNA processing." @default.
• W2604283208 created "2017-04-14" @default.
• W2604283208 creator A5003373949 @default.
• W2604283208 creator A5011326265 @default.
• W2604283208 creator A5034243534 @default.
• W2604283208 creator A5036540850 @default.
• W2604283208 creator A5036933165 @default.
• W2604283208 creator A5041032741 @default.
• W2604283208 creator A5041271315 @default.
• W2604283208 creator A5042132774 @default.
• W2604283208 creator A5042738577 @default.
• W2604283208 creator A5052870601 @default.
• W2604283208 creator A5058020729 @default.
• W2604283208 creator A5082643048 @default.
• W2604283208 creator A5087622468 @default.
• W2604283208 creator A5088553720 @default.
• W2604283208 date "2017-04-01" @default.
• W2604283208 modified "2023-10-02" @default.
• W2604283208 title "DGCR8 Mediates Repair of UV-Induced DNA Damage Independently of RNA Processing" @default.
• W2604283208 cites W176564998 @default.
• W2604283208 cites W1963893739 @default.
• W2604283208 cites W1965294807 @default.
• W2604283208 cites W1966621931 @default.
• W2604283208 cites W1971099302 @default.
• W2604283208 cites W1975519882 @default.
• W2604283208 cites W1979261061 @default.
• W2604283208 cites W1979782809 @default.
• W2604283208 cites W1989829234 @default.
• W2604283208 cites W1995828394 @default.
• W2604283208 cites W2003207389 @default.
• W2604283208 cites W2007991485 @default.
• W2604283208 cites W2011259241 @default.
• W2604283208 cites W2021414543 @default.
• W2604283208 cites W2029774509 @default.
• W2604283208 cites W2033983784 @default.
• W2604283208 cites W2034489183 @default.
• W2604283208 cites W2046082575 @default.
• W2604283208 cites W2051088438 @default.
• W2604283208 cites W2051801459 @default.
• W2604283208 cites W2052065943 @default.
• W2604283208 cites W2053130422 @default.
• W2604283208 cites W2055751200 @default.
• W2604283208 cites W2056832177 @default.
• W2604283208 cites W2056909284 @default.
• W2604283208 cites W2074072802 @default.
• W2604283208 cites W2078594804 @default.
• W2604283208 cites W2084214818 @default.
• W2604283208 cites W2090014412 @default.
• W2604283208 cites W2099253285 @default.
• W2604283208 cites W2099517697 @default.
• W2604283208 cites W2100932663 @default.
• W2604283208 cites W2105651504 @default.
• W2604283208 cites W2106488393 @default.
• W2604283208 cites W2109303819 @default.
• W2604283208 cites W2111471857 @default.
• W2604283208 cites W2112078820 @default.
• W2604283208 cites W2130706354 @default.
• W2604283208 cites W2131421168 @default.
• W2604283208 cites W2131475898 @default.
• W2604283208 cites W2142223308 @default.
• W2604283208 cites W2149441684 @default.
• W2604283208 cites W2159392012 @default.
• W2604283208 cites W2160681426 @default.
• W2604283208 cites W2162445149 @default.
• W2604283208 cites W2168631392 @default.
• W2604283208 cites W2168753894 @default.
• W2604283208 cites W2205741759 @default.
• W2604283208 cites W2320807456 @default.
• W2604283208 cites W138881307 @default.
• W2604283208 doi "https://doi.org/10.1016/j.celrep.2017.03.021" @default.
• W2604283208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5423785" @default.
• W2604283208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28380355" @default.
• W2604283208 hasPublicationYear "2017" @default.
• W2604283208 type Work @default.
• W2604283208 sameAs 2604283208 @default.
• W2604283208 citedByCount "26" @default.
• W2604283208 countsByYear W26042832082018 @default.
• W2604283208 countsByYear W26042832082019 @default.
• W2604283208 countsByYear W26042832082020 @default.
• W2604283208 countsByYear W26042832082021 @default.
• W2604283208 countsByYear W26042832082022 @default.
• W2604283208 countsByYear W26042832082023 @default.
• W2604283208 crossrefType "journal-article" @default.
• W2604283208 hasAuthorship W2604283208A5003373949 @default.
• W2604283208 hasAuthorship W2604283208A5011326265 @default.
• W2604283208 hasAuthorship W2604283208A5034243534 @default.
• W2604283208 hasAuthorship W2604283208A5036540850 @default.
• W2604283208 hasAuthorship W2604283208A5036933165 @default.
• W2604283208 hasAuthorship W2604283208A5041032741 @default.
• W2604283208 hasAuthorship W2604283208A5041271315 @default.
• W2604283208 hasAuthorship W2604283208A5042132774 @default.
• W2604283208 hasAuthorship W2604283208A5042738577 @default.
• W2604283208 hasAuthorship W2604283208A5052870601 @default.
• W2604283208 hasAuthorship W2604283208A5058020729 @default.
• W2604283208 hasAuthorship W2604283208A5082643048 @default.
• W2604283208 hasAuthorship W2604283208A5087622468 @default.
• W2604283208 hasAuthorship W2604283208A5088553720 @default.
• W2604283208 hasBestOaLocation W26042832081 @default.

• next