Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604283313> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2604283313 abstract "e21016 Background: Several reports suggest that cisplatin is associated with an increased risk of thromboembolism (TE). However, patients with solid tumors have multiple risk factors for TE and the excess risk of venous thromboembolic events (VTEs) with cisplatin-based chemotherapy as compared with non-cisplatin-based chemotherapy has not been well described. We performed a systemic review and meta-analysis of randomized controlled trials (RCTs) evaluating the incidence and risk of VTE associated with cisplatin-based chemotherapy. Methods: PubMed was searched for articles published from January 1, 1990 until December 31, 2010.The primary aim was to evaluate the association between treatment with cisplatin and VTEs in patients with cancer. Clinical trials that met the following criteria were included in the meta-analysis: (1) prospective randomized phase 2 and 3 trials of patients with cancer; (2) randomization to treatment with cisplatin versus a non-cisplatin containing chemotherapy regimen (3) available data on venous thromboembolic events. Data on all grade venous thromboembolic events was extracted. Study quality was calculated utilizing Jadad scores. Incidence rates, relative risks, and 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup analyses included the impact of publication year, tumor type, and cisplatin dose. Results: A total of 8216 patients with a variety of advanced solid tumors from 38 RCTs were included for analysis. Among patients treated with cisplatin-based chemotherapy, the summary incidence of VTE was 1.64% (95% CI, 1.06–2.25). Patients treated with cisplatin-based chemotherapy had a significantly increased risk of VTE with a relative risk of 1.65 (95% CI, 1.25–2.18; P = .01) compared with controls. Exploratory subgroup analysis revealed the highest relative risk of VTE in patients receiving a weekly equivalent cisplatin dose >30 mg/m 2 (2.64; 95% CI, 1.18–5.77; P = .02) and in studies reported during 2000-2010 (1.70; 95% CI, 1.27–2.28; P = .01). Conclusions: Cisplatin chemotherapy is associated with a significant increase in the risk of VTE in patients with advanced solid tumors compared with non-cisplatin chemotherapy." @default.
- W2604283313 created "2017-04-14" @default.
- W2604283313 creator A5001308517 @default.
- W2604283313 creator A5005272810 @default.
- W2604283313 creator A5041565080 @default.
- W2604283313 creator A5044784902 @default.
- W2604283313 creator A5052069729 @default.
- W2604283313 creator A5052504518 @default.
- W2604283313 creator A5057063597 @default.
- W2604283313 creator A5068086379 @default.
- W2604283313 creator A5078027978 @default.
- W2604283313 creator A5078128168 @default.
- W2604283313 creator A5084407364 @default.
- W2604283313 date "2012-05-20" @default.
- W2604283313 modified "2023-09-29" @default.
- W2604283313 title "Risk of venous thromboembolism in cancer patients treated with cisplatin: A systematic review and meta-analysis." @default.
- W2604283313 doi "https://doi.org/10.1200/jco.2012.30.15_suppl.e21016" @default.
- W2604283313 hasPublicationYear "2012" @default.
- W2604283313 type Work @default.
- W2604283313 sameAs 2604283313 @default.
- W2604283313 citedByCount "0" @default.
- W2604283313 crossrefType "journal-article" @default.
- W2604283313 hasAuthorship W2604283313A5001308517 @default.
- W2604283313 hasAuthorship W2604283313A5005272810 @default.
- W2604283313 hasAuthorship W2604283313A5041565080 @default.
- W2604283313 hasAuthorship W2604283313A5044784902 @default.
- W2604283313 hasAuthorship W2604283313A5052069729 @default.
- W2604283313 hasAuthorship W2604283313A5052504518 @default.
- W2604283313 hasAuthorship W2604283313A5057063597 @default.
- W2604283313 hasAuthorship W2604283313A5068086379 @default.
- W2604283313 hasAuthorship W2604283313A5078027978 @default.
- W2604283313 hasAuthorship W2604283313A5078128168 @default.
- W2604283313 hasAuthorship W2604283313A5084407364 @default.
- W2604283313 hasConcept C121608353 @default.
- W2604283313 hasConcept C126322002 @default.
- W2604283313 hasConcept C143998085 @default.
- W2604283313 hasConcept C177713679 @default.
- W2604283313 hasConcept C2776694085 @default.
- W2604283313 hasConcept C2778239845 @default.
- W2604283313 hasConcept C2780868729 @default.
- W2604283313 hasConcept C2991741193 @default.
- W2604283313 hasConcept C71924100 @default.
- W2604283313 hasConcept C95190672 @default.
- W2604283313 hasConceptScore W2604283313C121608353 @default.
- W2604283313 hasConceptScore W2604283313C126322002 @default.
- W2604283313 hasConceptScore W2604283313C143998085 @default.
- W2604283313 hasConceptScore W2604283313C177713679 @default.
- W2604283313 hasConceptScore W2604283313C2776694085 @default.
- W2604283313 hasConceptScore W2604283313C2778239845 @default.
- W2604283313 hasConceptScore W2604283313C2780868729 @default.
- W2604283313 hasConceptScore W2604283313C2991741193 @default.
- W2604283313 hasConceptScore W2604283313C71924100 @default.
- W2604283313 hasConceptScore W2604283313C95190672 @default.
- W2604283313 hasLocation W26042833131 @default.
- W2604283313 hasOpenAccess W2604283313 @default.
- W2604283313 hasPrimaryLocation W26042833131 @default.
- W2604283313 hasRelatedWork W2004815871 @default.
- W2604283313 hasRelatedWork W2040800118 @default.
- W2604283313 hasRelatedWork W2081540191 @default.
- W2604283313 hasRelatedWork W2132648488 @default.
- W2604283313 hasRelatedWork W2143547042 @default.
- W2604283313 hasRelatedWork W2146354359 @default.
- W2604283313 hasRelatedWork W2161997667 @default.
- W2604283313 hasRelatedWork W2292388772 @default.
- W2604283313 hasRelatedWork W2315953954 @default.
- W2604283313 hasRelatedWork W2564533306 @default.
- W2604283313 hasRelatedWork W2566774609 @default.
- W2604283313 hasRelatedWork W2586728125 @default.
- W2604283313 hasRelatedWork W2766870001 @default.
- W2604283313 hasRelatedWork W2793042429 @default.
- W2604283313 hasRelatedWork W2996270284 @default.
- W2604283313 hasRelatedWork W3028180427 @default.
- W2604283313 hasRelatedWork W3104606679 @default.
- W2604283313 hasRelatedWork W3115477459 @default.
- W2604283313 hasRelatedWork W3168255462 @default.
- W2604283313 hasRelatedWork W3208736733 @default.
- W2604283313 isParatext "false" @default.
- W2604283313 isRetracted "false" @default.
- W2604283313 magId "2604283313" @default.
- W2604283313 workType "article" @default.