Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604294562> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2604294562 abstract "Background: After achieving “clinically undetectable levels”, many HIV positive individuals remain in a phase called residual viremia. Some of these patients have viral blips, while others have viral rebounds, but little is known about their causes. Our objective was to identify the rate and determinants of viral load dynamics, particularly the effect of hazardous alcohol use. Methods: We evaluated 400 cohort participants starting ART and comprehensively assessed alcohol intakes using validated instruments. Viral load (VL) was measured at four time points (baseline, 6 12 and 18 months), along with potential covariates, such as demographics, CD4, CD8, platelets, alcohol use profiles, and medication adherence. VL suppression was assessed at 6 months and then based on prior published work, viral trajectories were censored according to the following categories: reference Group 1 (very low viremia<50), viral blips Group 2 (50-399), and the viral rebound Group 3 (400-1000 copies/mL). Factors associated with VLV, blips, and rebounds were identified using logistic regression models. Results: Among the 320 subjects who achieved undetectable viral loads, during the subsequent 12 months of therapy, 20% exhibited viral blips, and 43% had viral rebounds. Despite similar medication adherence (95% vs. 85%), hazardous alcohol users were twice more likely to have a viral rebound, compared with non-users (95% CI, 1.8-2.5; p=0. 000). Alcohol users were also more likely to have blips. After adjustment for potential confounders, regression analyses indicated that CD4 counts at the time of therapy initiation, alcohol use, and age were independently associated with blips and rebounds. Conclusions: In this cohort, hazardous alcohol use was associated with an increased risk of viral blips, and thus will likely play an important role in the development of effective strategies to eliminate HIV, and prevent transmission and disease progression. These findings have implications for clinicians, researchers and policy makers, as they highlight the detrimental effects of alcohol use while on ART therapy." @default.
- W2604294562 created "2017-04-14" @default.
- W2604294562 creator A5022469672 @default.
- W2604294562 creator A5029173822 @default.
- W2604294562 creator A5032677579 @default.
- W2604294562 creator A5062302784 @default.
- W2604294562 creator A5063343955 @default.
- W2604294562 date "2016-01-01" @default.
- W2604294562 modified "2023-09-26" @default.
- W2604294562 title "The Impact of Alcohol use during Seemingly Suppressive Antiretroviral Therapy: Risk of Blips and Rebounds" @default.
- W2604294562 doi "https://doi.org/10.4172/2572-0805.1000115" @default.
- W2604294562 hasPublicationYear "2016" @default.
- W2604294562 type Work @default.
- W2604294562 sameAs 2604294562 @default.
- W2604294562 citedByCount "0" @default.
- W2604294562 crossrefType "journal-article" @default.
- W2604294562 hasAuthorship W2604294562A5022469672 @default.
- W2604294562 hasAuthorship W2604294562A5029173822 @default.
- W2604294562 hasAuthorship W2604294562A5032677579 @default.
- W2604294562 hasAuthorship W2604294562A5062302784 @default.
- W2604294562 hasAuthorship W2604294562A5063343955 @default.
- W2604294562 hasBestOaLocation W26042945621 @default.
- W2604294562 hasConcept C126322002 @default.
- W2604294562 hasConcept C142462285 @default.
- W2604294562 hasConcept C151956035 @default.
- W2604294562 hasConcept C201903717 @default.
- W2604294562 hasConcept C203014093 @default.
- W2604294562 hasConcept C205545832 @default.
- W2604294562 hasConcept C2522874641 @default.
- W2604294562 hasConcept C2776185481 @default.
- W2604294562 hasConcept C71924100 @default.
- W2604294562 hasConcept C72563966 @default.
- W2604294562 hasConcept C77350462 @default.
- W2604294562 hasConceptScore W2604294562C126322002 @default.
- W2604294562 hasConceptScore W2604294562C142462285 @default.
- W2604294562 hasConceptScore W2604294562C151956035 @default.
- W2604294562 hasConceptScore W2604294562C201903717 @default.
- W2604294562 hasConceptScore W2604294562C203014093 @default.
- W2604294562 hasConceptScore W2604294562C205545832 @default.
- W2604294562 hasConceptScore W2604294562C2522874641 @default.
- W2604294562 hasConceptScore W2604294562C2776185481 @default.
- W2604294562 hasConceptScore W2604294562C71924100 @default.
- W2604294562 hasConceptScore W2604294562C72563966 @default.
- W2604294562 hasConceptScore W2604294562C77350462 @default.
- W2604294562 hasLocation W26042945621 @default.
- W2604294562 hasOpenAccess W2604294562 @default.
- W2604294562 hasPrimaryLocation W26042945621 @default.
- W2604294562 hasRelatedWork W1584074243 @default.
- W2604294562 hasRelatedWork W1934867323 @default.
- W2604294562 hasRelatedWork W1994569822 @default.
- W2604294562 hasRelatedWork W2007513939 @default.
- W2604294562 hasRelatedWork W2099121455 @default.
- W2604294562 hasRelatedWork W2118829236 @default.
- W2604294562 hasRelatedWork W2123179942 @default.
- W2604294562 hasRelatedWork W2171149970 @default.
- W2604294562 hasRelatedWork W2207751238 @default.
- W2604294562 hasRelatedWork W2463941766 @default.
- W2604294562 hasRelatedWork W2537820607 @default.
- W2604294562 hasRelatedWork W2806465162 @default.
- W2604294562 hasRelatedWork W2809616318 @default.
- W2604294562 hasRelatedWork W2942485869 @default.
- W2604294562 hasRelatedWork W2981540939 @default.
- W2604294562 hasRelatedWork W2990676722 @default.
- W2604294562 hasRelatedWork W3033543278 @default.
- W2604294562 hasRelatedWork W3113052361 @default.
- W2604294562 hasRelatedWork W3212625518 @default.
- W2604294562 hasRelatedWork W785269893 @default.
- W2604294562 isParatext "false" @default.
- W2604294562 isRetracted "false" @default.
- W2604294562 magId "2604294562" @default.
- W2604294562 workType "article" @default.