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- W2604313146 abstract "Frontline chemotherapy is successful against chronic lymphocytic leukemia (CLL), but results in untoward toxicity. Further, prognostic factors, cytogenetic anomalies, and compensatory cellular signaling lead to therapy resistance or disease relapse. Therefore, for the past few years, development of targeted therapies is on the rise. PI3K is a major player in the B-cell receptor (BCR) signaling axis, which is critical for the survival and maintenance of B cells. Duvelisib, a PI3K δ/γ dual isoform specific inhibitor that induces apoptosis and reduces cytokine and chemokine levels in vitro, holds promise for CLL. Areas covered: Herein, we review PI3K isoforms and their inhibitors in general, and duvelisib in particular; examine literature on preclinical investigations, pharmacokinetics and clinical studies of duvelisib either as single agent or in combination, for patients with CLL and other lymphoid malignancies. Expert opinion: Duvelisib targets the PI3K δ isoform, which is necessary for cell proliferation and survival, and γ isoform, which is critical for cytokine signaling and pro-inflammatory responses from the microenvironment. In phase I clinical trials, duvelisib as a single agent showed promise for CLL and other lymphoid malignancies. Phase II and III trials of duvelisib alone or in combination with other agents are ongoing." @default.
- W2604313146 created "2017-04-14" @default.
- W2604313146 creator A5021380291 @default.
- W2604313146 creator A5023232275 @default.
- W2604313146 creator A5024454882 @default.
- W2604313146 date "2017-04-13" @default.
- W2604313146 modified "2023-10-01" @default.
- W2604313146 title "Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia" @default.
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- W2604313146 doi "https://doi.org/10.1080/13543784.2017.1312338" @default.
- W2604313146 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5584596" @default.
- W2604313146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28388280" @default.
- W2604313146 hasPublicationYear "2017" @default.
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