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- W2604317589 endingPage "41763" @default.
- W2604317589 startingPage "41749" @default.
- W2604317589 abstract "LIM kinases are common downstream effectors of several signalization pathways and function as a signaling node that controls cytoskeleton dynamics through the phosphorylation of the cofilin family proteins. These last 10 years, several reports indicate that the functions of LIM kinases are more extended than initially described and, specifically, that LIM kinases also control microtubule dynamics, independently of their regulation of actin microfilament. In this review we analyze the data supporting these conclusions and the possible mechanisms that could be involved in the control of microtubules by LIM kinases. The demonstration that LIM kinases also control microtubule dynamics has pointed to new therapeutic opportunities. Consistently, several new LIM kinase inhibitors have been recently developed. We provide a comprehensive comparison of these inhibitors, of their chemical structure, their specificity, their cellular effects as well as their effects in animal models of various diseases including cancer." @default.
- W2604317589 created "2017-04-14" @default.
- W2604317589 creator A5035841414 @default.
- W2604317589 creator A5058753643 @default.
- W2604317589 creator A5065304431 @default.
- W2604317589 creator A5070083140 @default.
- W2604317589 creator A5074951005 @default.
- W2604317589 date "2017-04-09" @default.
- W2604317589 modified "2023-09-30" @default.
- W2604317589 title "LIM kinases: cofilin and beyond" @default.
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