FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604328863> ?p ?o ?g. }

• W2604328863 endingPage "587" @default.
• W2604328863 startingPage "581" @default.
• W2604328863 abstract "The epithelial-mesenchymal transition (EMT) plays an important role in inducing cancer metastasis. Baicalin, a flavone derivative isolated from Scutellaria spp., shows a series of pharmacological and physiological activities. However, the possible role of baicalin in the EMT is unclear. In this study, we attempted to investigate the potential use of baicalin as an inhibitor of transforming growth factor-β1 (TGF-β1)-induced EMT in U2OS cells. We found that TGF-β1 induced the EMT to promote U2OS cells migration, invasion, and anoikis resistance. Western blotting showed that baicalin inhibited U2OS cells' invasion and migration, increased the expression of the epithelial phenotype marker E-cadherin, repressed the expression of the mesenchymal phenotype marker vimentin, as well as decreased the level of EMT-inducing transcription factors Snail1 and Slug during the initiation of TGF-β1-induced EMT. Baicalin also inhibited the TGF-β1-induced increase in cell migration, invasion, and anoikis resistance in TGF-β1-induced U2OS cells. In addition, the TGF-β1-mediated phosphorylated levels of Smad2/3 were inhibited by baicalin pretreatment. Above all, we conclude that baicalin suppresses human osteosarcoma cells' migration, invasion, and anoikis resistance in vitro through suppression of TGF-β1-induced EMT." @default.
• W2604328863 created "2017-04-14" @default.
• W2604328863 creator A5005977892 @default.
• W2604328863 creator A5009331396 @default.
• W2604328863 creator A5019989341 @default.
• W2604328863 creator A5030045320 @default.
• W2604328863 creator A5051549836 @default.
• W2604328863 creator A5057723713 @default.
• W2604328863 creator A5088684298 @default.
• W2604328863 date "2017-07-01" @default.
• W2604328863 modified "2023-10-13" @default.
• W2604328863 title "Baicalin inhibits human osteosarcoma cells invasion, metastasis, and anoikis resistance by suppressing the transforming growth factor-β1-induced epithelial-to-mesenchymal transition" @default.
• W2604328863 cites W1488829562 @default.
• W2604328863 cites W1566467768 @default.
• W2604328863 cites W1964081206 @default.
• W2604328863 cites W1964314383 @default.
• W2604328863 cites W1965605768 @default.
• W2604328863 cites W1983472990 @default.
• W2604328863 cites W1988325237 @default.
• W2604328863 cites W1992668691 @default.
• W2604328863 cites W1997258453 @default.
• W2604328863 cites W2002450099 @default.
• W2604328863 cites W2002586148 @default.
• W2604328863 cites W2003020933 @default.
• W2604328863 cites W2009877714 @default.
• W2604328863 cites W2018062382 @default.
• W2604328863 cites W2018649033 @default.
• W2604328863 cites W2024405339 @default.
• W2604328863 cites W2024980041 @default.
• W2604328863 cites W2025475845 @default.
• W2604328863 cites W2035255090 @default.
• W2604328863 cites W2051190668 @default.
• W2604328863 cites W2055574918 @default.
• W2604328863 cites W2060225624 @default.
• W2604328863 cites W2061958868 @default.
• W2604328863 cites W2122390343 @default.
• W2604328863 cites W2122808924 @default.
• W2604328863 cites W2133193835 @default.
• W2604328863 cites W2146654096 @default.
• W2604328863 cites W2154568166 @default.
• W2604328863 cites W2165901622 @default.
• W2604328863 cites W2275662976 @default.
• W2604328863 doi "https://doi.org/10.1097/cad.0000000000000495" @default.
• W2604328863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28379900" @default.
• W2604328863 hasPublicationYear "2017" @default.
• W2604328863 type Work @default.
• W2604328863 sameAs 2604328863 @default.
• W2604328863 citedByCount "35" @default.
• W2604328863 countsByYear W26043288632017 @default.
• W2604328863 countsByYear W26043288632018 @default.
• W2604328863 countsByYear W26043288632019 @default.
• W2604328863 countsByYear W26043288632020 @default.
• W2604328863 countsByYear W26043288632021 @default.
• W2604328863 countsByYear W26043288632022 @default.
• W2604328863 countsByYear W26043288632023 @default.
• W2604328863 crossrefType "journal-article" @default.
• W2604328863 hasAuthorship W2604328863A5005977892 @default.
• W2604328863 hasAuthorship W2604328863A5009331396 @default.
• W2604328863 hasAuthorship W2604328863A5019989341 @default.
• W2604328863 hasAuthorship W2604328863A5030045320 @default.
• W2604328863 hasAuthorship W2604328863A5051549836 @default.
• W2604328863 hasAuthorship W2604328863A5057723713 @default.
• W2604328863 hasAuthorship W2604328863A5088684298 @default.
• W2604328863 hasConcept C118131993 @default.
• W2604328863 hasConcept C121608353 @default.
• W2604328863 hasConcept C137738243 @default.
• W2604328863 hasConcept C147447768 @default.
• W2604328863 hasConcept C1491633281 @default.
• W2604328863 hasConcept C152000582 @default.
• W2604328863 hasConcept C179998833 @default.
• W2604328863 hasConcept C185592680 @default.
• W2604328863 hasConcept C198826908 @default.
• W2604328863 hasConcept C203014093 @default.
• W2604328863 hasConcept C204232928 @default.
• W2604328863 hasConcept C2777760704 @default.
• W2604328863 hasConcept C2779013556 @default.
• W2604328863 hasConcept C2780113650 @default.
• W2604328863 hasConcept C43617362 @default.
• W2604328863 hasConcept C502942594 @default.
• W2604328863 hasConcept C54355233 @default.
• W2604328863 hasConcept C55493867 @default.
• W2604328863 hasConcept C76419328 @default.
• W2604328863 hasConcept C86803240 @default.
• W2604328863 hasConcept C95444343 @default.
• W2604328863 hasConceptScore W2604328863C118131993 @default.
• W2604328863 hasConceptScore W2604328863C121608353 @default.
• W2604328863 hasConceptScore W2604328863C137738243 @default.
• W2604328863 hasConceptScore W2604328863C147447768 @default.
• W2604328863 hasConceptScore W2604328863C1491633281 @default.
• W2604328863 hasConceptScore W2604328863C152000582 @default.
• W2604328863 hasConceptScore W2604328863C179998833 @default.
• W2604328863 hasConceptScore W2604328863C185592680 @default.
• W2604328863 hasConceptScore W2604328863C198826908 @default.
• W2604328863 hasConceptScore W2604328863C203014093 @default.
• W2604328863 hasConceptScore W2604328863C204232928 @default.
• W2604328863 hasConceptScore W2604328863C2777760704 @default.
• W2604328863 hasConceptScore W2604328863C2779013556 @default.
• W2604328863 hasConceptScore W2604328863C2780113650 @default.

• next