Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604365942> ?p ?o ?g. }
- W2604365942 abstract "Abstract Immature neural circuits undergo synaptic refinement, in which activity-dependent competition between synapses results in pruning of inappropriate connections and maintenance of appropriate ones. A longstanding question is how neuronal activity eliminates specific synapses based on their strength. The technical challenges of in vivo studies have made it difficult to identify a molecular link between decreased activity and synapse elimination. We developed an organotypic coculture model of the mouse retinogeniculate system that facilitates real-time imaging and elucidation of molecular mechanisms underlying the removal of less active synapses during synaptic competition. Using this model we show for the first time that complement component C1q is necessary for activity-dependent synaptic competition and preferentially localizes to less active, competing presynaptic inputs. In conjunction with classic in vivo and ex vivo models, this coculture model is a new tool to reveal molecular pathways underlying CNS circuit refinement." @default.
- W2604365942 created "2017-04-14" @default.
- W2604365942 creator A5013620503 @default.
- W2604365942 creator A5019182420 @default.
- W2604365942 creator A5032725432 @default.
- W2604365942 creator A5052490807 @default.
- W2604365942 creator A5054466331 @default.
- W2604365942 creator A5057698942 @default.
- W2604365942 creator A5059788862 @default.
- W2604365942 creator A5076469919 @default.
- W2604365942 date "2017-03-20" @default.
- W2604365942 modified "2023-10-03" @default.
- W2604365942 title "A new organotypic model of synaptic competition reveals activity-dependent localization of C1q" @default.
- W2604365942 cites W1488335717 @default.
- W2604365942 cites W1555017510 @default.
- W2604365942 cites W1600525795 @default.
- W2604365942 cites W1612805808 @default.
- W2604365942 cites W1615533678 @default.
- W2604365942 cites W1794552313 @default.
- W2604365942 cites W1873878478 @default.
- W2604365942 cites W1963806203 @default.
- W2604365942 cites W1964372429 @default.
- W2604365942 cites W1964434595 @default.
- W2604365942 cites W1966403223 @default.
- W2604365942 cites W1968687181 @default.
- W2604365942 cites W1971339419 @default.
- W2604365942 cites W1975196303 @default.
- W2604365942 cites W1978596696 @default.
- W2604365942 cites W1985342948 @default.
- W2604365942 cites W1996545009 @default.
- W2604365942 cites W2001949196 @default.
- W2604365942 cites W2012001963 @default.
- W2604365942 cites W2012524043 @default.
- W2604365942 cites W2014443309 @default.
- W2604365942 cites W2016891453 @default.
- W2604365942 cites W2018843440 @default.
- W2604365942 cites W2018961236 @default.
- W2604365942 cites W2020634566 @default.
- W2604365942 cites W2023583278 @default.
- W2604365942 cites W2026397702 @default.
- W2604365942 cites W2033617297 @default.
- W2604365942 cites W2034570753 @default.
- W2604365942 cites W2035145219 @default.
- W2604365942 cites W2039729026 @default.
- W2604365942 cites W2043279954 @default.
- W2604365942 cites W2044654523 @default.
- W2604365942 cites W2046232210 @default.
- W2604365942 cites W2049578043 @default.
- W2604365942 cites W2050923395 @default.
- W2604365942 cites W2053850015 @default.
- W2604365942 cites W2065189089 @default.
- W2604365942 cites W2065958702 @default.
- W2604365942 cites W2066480427 @default.
- W2604365942 cites W2074661425 @default.
- W2604365942 cites W2076041927 @default.
- W2604365942 cites W2076657715 @default.
- W2604365942 cites W2082174343 @default.
- W2604365942 cites W2089178397 @default.
- W2604365942 cites W2092959146 @default.
- W2604365942 cites W2096327192 @default.
- W2604365942 cites W2102675403 @default.
- W2604365942 cites W2120441742 @default.
- W2604365942 cites W2121379737 @default.
- W2604365942 cites W2125236750 @default.
- W2604365942 cites W2130486822 @default.
- W2604365942 cites W2134505400 @default.
- W2604365942 cites W2134888296 @default.
- W2604365942 cites W2137445935 @default.
- W2604365942 cites W2145961463 @default.
- W2604365942 cites W2150947418 @default.
- W2604365942 cites W2151498098 @default.
- W2604365942 cites W2157622411 @default.
- W2604365942 cites W2162407586 @default.
- W2604365942 cites W2165773242 @default.
- W2604365942 cites W2255138985 @default.
- W2604365942 cites W2314634699 @default.
- W2604365942 cites W2317516423 @default.
- W2604365942 cites W2341088037 @default.
- W2604365942 cites W4243765060 @default.
- W2604365942 cites W93232367 @default.
- W2604365942 doi "https://doi.org/10.1101/118646" @default.
- W2604365942 hasPublicationYear "2017" @default.
- W2604365942 type Work @default.
- W2604365942 sameAs 2604365942 @default.
- W2604365942 citedByCount "0" @default.
- W2604365942 crossrefType "posted-content" @default.
- W2604365942 hasAuthorship W2604365942A5013620503 @default.
- W2604365942 hasAuthorship W2604365942A5019182420 @default.
- W2604365942 hasAuthorship W2604365942A5032725432 @default.
- W2604365942 hasAuthorship W2604365942A5052490807 @default.
- W2604365942 hasAuthorship W2604365942A5054466331 @default.
- W2604365942 hasAuthorship W2604365942A5057698942 @default.
- W2604365942 hasAuthorship W2604365942A5059788862 @default.
- W2604365942 hasAuthorship W2604365942A5076469919 @default.
- W2604365942 hasBestOaLocation W26043659421 @default.
- W2604365942 hasConcept C108010975 @default.
- W2604365942 hasConcept C118403218 @default.
- W2604365942 hasConcept C127445978 @default.
- W2604365942 hasConcept C150903083 @default.
- W2604365942 hasConcept C169760540 @default.