FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604384746> ?p ?o ?g. }

• W2604384746 endingPage "303" @default.
• W2604384746 startingPage "293" @default.
• W2604384746 abstract "Background: Prevalent worldwide obesity is associated with increased incidence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. The identification of noninvasive biomarkers for NAFLD is of recent interest. Because primary de novo lipogenesis occurs in chicken liver as in human liver, adult chickens with age-associated steatosis resembling human NAFLD is an appealing animal model. Objective: The objective of this study was to screen potential biomarkers in the chicken model for NAFLD by transcriptomic and proteomic analysis. Methods: Hy-Line W-36 laying hens were fed standard feed from 25 to 45 wk of age to induce fatty liver. They were killed every 4 wk, and liver and plasma were collected at each time point to assess fatty liver development and for transcriptomic and proteomic analysis. Next, selected biomarkers were confirmed in additional experiments by providing supplements of the hepatoprotective nutrients betaine [300, 600, or 900 parts per million (ppm) in vivo; 2 mM in vitro] or docosahexaenoic acid (DHA; 1% in vivo; 100 μM in vitro) to 30-wk-old Hy-Line W-36 laying hens for 4 mo and to Hy-Line W-36 chicken primary hepatocytes with oleic acid–induced steatosis. Liver or hepatocyte lipid contents and the expression of biomarkers were then examined. Results: Plasma acetoacetyl-CoA synthetase (AACS), dipeptidyl-peptidase 4 (DPP4), glutamine synthetase (GLUL), and glutathione S-transferase (GST) concentrations are well-established biomarkers for NAFLD. Selected biomarkers had significant positive associations with hepatic lipid deposition (P < 0.001). Betaine (900 ppm in vivo; 2 mM in vitro) and DHA (1% in vivo; 100 μM in vitro) supplementation both resulted in lower steatosis accompanied by the reduced expression of selected biomarkers in vivo and in vitro (P < 0.05). Conclusion: This study used adult laying hens to identify biomarkers for NAFLD and indicated that AACS, DPP4, GLUL, and GST could be considered to be potential diagnostic indicators for NAFLD in the future." @default.
• W2604384746 created "2017-04-14" @default.
• W2604384746 creator A5024747428 @default.
• W2604384746 creator A5032427357 @default.
• W2604384746 creator A5032536480 @default.
• W2604384746 creator A5043916095 @default.
• W2604384746 creator A5062515455 @default.
• W2604384746 creator A5064655192 @default.
• W2604384746 creator A5066660679 @default.
• W2604384746 creator A5077541450 @default.
• W2604384746 date "2017-01-11" @default.
• W2604384746 modified "2023-10-14" @default.
• W2604384746 title "Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens" @default.
• W2604384746 cites W109033710 @default.
• W2604384746 cites W1576878402 @default.
• W2604384746 cites W1659486020 @default.
• W2604384746 cites W1758497516 @default.
• W2604384746 cites W1768418175 @default.
• W2604384746 cites W1856151485 @default.
• W2604384746 cites W1892489556 @default.
• W2604384746 cites W1926691574 @default.
• W2604384746 cites W1967877552 @default.
• W2604384746 cites W1969295126 @default.
• W2604384746 cites W1969981116 @default.
• W2604384746 cites W1973895295 @default.
• W2604384746 cites W1978968478 @default.
• W2604384746 cites W1979002038 @default.
• W2604384746 cites W1985941275 @default.
• W2604384746 cites W1999118365 @default.
• W2604384746 cites W2001425475 @default.
• W2604384746 cites W2002019432 @default.
• W2604384746 cites W2012528744 @default.
• W2604384746 cites W2025207707 @default.
• W2604384746 cites W2025843189 @default.
• W2604384746 cites W2038741829 @default.
• W2604384746 cites W2042324298 @default.
• W2604384746 cites W2045653720 @default.
• W2604384746 cites W2055183906 @default.
• W2604384746 cites W2055306790 @default.
• W2604384746 cites W2079021980 @default.
• W2604384746 cites W2081909517 @default.
• W2604384746 cites W2089060803 @default.
• W2604384746 cites W2089229117 @default.
• W2604384746 cites W2090661228 @default.
• W2604384746 cites W2091226975 @default.
• W2604384746 cites W2099540110 @default.
• W2604384746 cites W2100305481 @default.
• W2604384746 cites W2104567704 @default.
• W2604384746 cites W2112496618 @default.
• W2604384746 cites W2114825802 @default.
• W2604384746 cites W2115681156 @default.
• W2604384746 cites W2118283011 @default.
• W2604384746 cites W2118993579 @default.
• W2604384746 cites W2128157888 @default.
• W2604384746 cites W2128366104 @default.
• W2604384746 cites W2131094572 @default.
• W2604384746 cites W2132897895 @default.
• W2604384746 cites W2136909828 @default.
• W2604384746 cites W2141962989 @default.
• W2604384746 cites W2144275312 @default.
• W2604384746 cites W2147785884 @default.
• W2604384746 cites W2166202304 @default.
• W2604384746 cites W2166820820 @default.
• W2604384746 cites W2167097898 @default.
• W2604384746 cites W2182073955 @default.
• W2604384746 cites W2282195703 @default.
• W2604384746 cites W2324165791 @default.
• W2604384746 cites W2333336217 @default.
• W2604384746 cites W4247258598 @default.
• W2604384746 doi "https://doi.org/10.3945/jn.116.240358" @default.
• W2604384746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28077733" @default.
• W2604384746 hasPublicationYear "2017" @default.
• W2604384746 type Work @default.
• W2604384746 sameAs 2604384746 @default.
• W2604384746 citedByCount "25" @default.
• W2604384746 countsByYear W26043847462017 @default.
• W2604384746 countsByYear W26043847462018 @default.
• W2604384746 countsByYear W26043847462019 @default.
• W2604384746 countsByYear W26043847462020 @default.
• W2604384746 countsByYear W26043847462021 @default.
• W2604384746 countsByYear W26043847462022 @default.
• W2604384746 countsByYear W26043847462023 @default.
• W2604384746 crossrefType "journal-article" @default.
• W2604384746 hasAuthorship W2604384746A5024747428 @default.
• W2604384746 hasAuthorship W2604384746A5032427357 @default.
• W2604384746 hasAuthorship W2604384746A5032536480 @default.
• W2604384746 hasAuthorship W2604384746A5043916095 @default.
• W2604384746 hasAuthorship W2604384746A5062515455 @default.
• W2604384746 hasAuthorship W2604384746A5064655192 @default.
• W2604384746 hasAuthorship W2604384746A5066660679 @default.
• W2604384746 hasAuthorship W2604384746A5077541450 @default.
• W2604384746 hasBestOaLocation W26043847461 @default.
• W2604384746 hasConcept C126322002 @default.
• W2604384746 hasConcept C134018914 @default.
• W2604384746 hasConcept C141359234 @default.
• W2604384746 hasConcept C150903083 @default.
• W2604384746 hasConcept C207001950 @default.
• W2604384746 hasConcept C2776175330 @default.

• next