FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604410366> ?p ?o ?g. }

• W2604410366 endingPage "534" @default.
• W2604410366 startingPage "525" @default.
• W2604410366 abstract "XIST is an X-linked, non-coding gene responsible for the cis induction of X-chromosome inactivation (XCI). Knockout of the XIST allele on an active X chromosome abolishes erroneous XCI and enhances the in vivo development of cloned mouse embryos by more than 10-fold. This study aimed to investigate whether a similar manipulation would improve cloning efficiency in pigs. A male, porcine kidney cell line containing an EGFP insert in exon 1 of the XIST gene, resulting in a knockout allele (XIST-KO), was generated by homologous recombination using transcription activator-like effector nucleases (TALENs). The expression of X-linked genes in embryos cloned from the XIST-KO kidney cells was significantly higher than in male embryos cloned from wild-type (WT) kidney cells, but remained lower than that of in vivo fertilization-produced counterparts. The XIST-KO cloned embryos also had a significantly lower blastocyst rate and a reduced full-term development rate compared to cloned WT embryos. These data suggested that while mutation of a XIST gene can partially rescue abnormal XCI, it cannot improve the developmental efficiency of cloned male porcine embryos—a deficiency that may be caused by incomplete rescue of abnormal XCI and/or by long-term drug selection of the XIST-KO nuclear donor cells, which might adversely affect the developmental efficiency of embryos created from them." @default.
• W2604410366 created "2017-04-14" @default.
• W2604410366 creator A5005710285 @default.
• W2604410366 creator A5018626143 @default.
• W2604410366 creator A5019844412 @default.
• W2604410366 creator A5023500890 @default.
• W2604410366 creator A5049692788 @default.
• W2604410366 creator A5055233272 @default.
• W2604410366 creator A5058026071 @default.
• W2604410366 creator A5065987768 @default.
• W2604410366 creator A5083860977 @default.
• W2604410366 creator A5084752971 @default.
• W2604410366 creator A5090269873 @default.
• W2604410366 date "2017-05-04" @default.
• W2604410366 modified "2023-10-15" @default.
• W2604410366 title "Mutation of the <i>XIST</i> gene upregulates expression of X-linked genes but decreases the developmental rates of cloned male porcine embryos" @default.
• W2604410366 cites W1016134549 @default.
• W2604410366 cites W1791057941 @default.
• W2604410366 cites W1980267772 @default.
• W2604410366 cites W1997100349 @default.
• W2604410366 cites W1999951126 @default.
• W2604410366 cites W2000007630 @default.
• W2604410366 cites W2014071735 @default.
• W2604410366 cites W2021122622 @default.
• W2604410366 cites W2029146706 @default.
• W2604410366 cites W2049410248 @default.
• W2604410366 cites W2049618939 @default.
• W2604410366 cites W2050608300 @default.
• W2604410366 cites W2057565269 @default.
• W2604410366 cites W2081324839 @default.
• W2604410366 cites W2088425611 @default.
• W2604410366 cites W2093068860 @default.
• W2604410366 cites W2094429619 @default.
• W2604410366 cites W2100773322 @default.
• W2604410366 cites W2102952295 @default.
• W2604410366 cites W2125577657 @default.
• W2604410366 cites W2128510424 @default.
• W2604410366 cites W2132182437 @default.
• W2604410366 cites W2134778869 @default.
• W2604410366 cites W2141458291 @default.
• W2604410366 cites W2222784917 @default.
• W2604410366 cites W2316095770 @default.
• W2604410366 cites W2509505655 @default.
• W2604410366 cites W2523309919 @default.
• W2604410366 doi "https://doi.org/10.1002/mrd.22808" @default.
• W2604410366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28387970" @default.
• W2604410366 hasPublicationYear "2017" @default.
• W2604410366 type Work @default.
• W2604410366 sameAs 2604410366 @default.
• W2604410366 citedByCount "4" @default.
• W2604410366 countsByYear W26044103662019 @default.
• W2604410366 countsByYear W26044103662021 @default.
• W2604410366 countsByYear W26044103662022 @default.
• W2604410366 crossrefType "journal-article" @default.
• W2604410366 hasAuthorship W2604410366A5005710285 @default.
• W2604410366 hasAuthorship W2604410366A5018626143 @default.
• W2604410366 hasAuthorship W2604410366A5019844412 @default.
• W2604410366 hasAuthorship W2604410366A5023500890 @default.
• W2604410366 hasAuthorship W2604410366A5049692788 @default.
• W2604410366 hasAuthorship W2604410366A5055233272 @default.
• W2604410366 hasAuthorship W2604410366A5058026071 @default.
• W2604410366 hasAuthorship W2604410366A5065987768 @default.
• W2604410366 hasAuthorship W2604410366A5083860977 @default.
• W2604410366 hasAuthorship W2604410366A5084752971 @default.
• W2604410366 hasAuthorship W2604410366A5090269873 @default.
• W2604410366 hasConcept C104317684 @default.
• W2604410366 hasConcept C110411900 @default.
• W2604410366 hasConcept C127716648 @default.
• W2604410366 hasConcept C153911025 @default.
• W2604410366 hasConcept C196843134 @default.
• W2604410366 hasConcept C2778177303 @default.
• W2604410366 hasConcept C35158069 @default.
• W2604410366 hasConcept C4323932 @default.
• W2604410366 hasConcept C54355233 @default.
• W2604410366 hasConcept C68838962 @default.
• W2604410366 hasConcept C86803240 @default.
• W2604410366 hasConcept C87073359 @default.
• W2604410366 hasConceptScore W2604410366C104317684 @default.
• W2604410366 hasConceptScore W2604410366C110411900 @default.
• W2604410366 hasConceptScore W2604410366C127716648 @default.
• W2604410366 hasConceptScore W2604410366C153911025 @default.
• W2604410366 hasConceptScore W2604410366C196843134 @default.
• W2604410366 hasConceptScore W2604410366C2778177303 @default.
• W2604410366 hasConceptScore W2604410366C35158069 @default.
• W2604410366 hasConceptScore W2604410366C4323932 @default.
• W2604410366 hasConceptScore W2604410366C54355233 @default.
• W2604410366 hasConceptScore W2604410366C68838962 @default.
• W2604410366 hasConceptScore W2604410366C86803240 @default.
• W2604410366 hasConceptScore W2604410366C87073359 @default.
• W2604410366 hasFunder F4320324202 @default.
• W2604410366 hasIssue "6" @default.
• W2604410366 hasLocation W26044103661 @default.
• W2604410366 hasLocation W26044103662 @default.
• W2604410366 hasOpenAccess W2604410366 @default.
• W2604410366 hasPrimaryLocation W26044103661 @default.
• W2604410366 hasRelatedWork W1985658425 @default.
• W2604410366 hasRelatedWork W2119299386 @default.
• W2604410366 hasRelatedWork W2134510303 @default.

• next