Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604419714> ?p ?o ?g. }
- W2604419714 endingPage "768" @default.
- W2604419714 startingPage "768" @default.
- W2604419714 abstract "The ghrelin receptor (GhrR) is a widely investigated target in several diseases. However, the current knowledge of its role and distribution in the brain is limited. Recently, the small and non-peptidic compound (S)-6-(4-bromo-2-fluorophenoxy)-3-((1-isopropylpiperidin-3-yl)methyl)-2-methylpyrido[3,2-d]pyrimidin-4(3H)-one ((S)-9) has been described as a GhrR ligand with high binding affinity. Here, we describe the synthesis of fluorinated derivatives, the in vitro evaluation of their potency as partial agonists and selectivity at GhrRs, and their physicochemical properties. These results identified compounds (S)-9, (R)-9, and (S)-16 as suitable parent molecules for 18F-labeled positron emission tomography (PET) radiotracers to enable future investigation of GhrR in the brain." @default.
- W2604419714 created "2017-04-14" @default.
- W2604419714 creator A5001999246 @default.
- W2604419714 creator A5012059772 @default.
- W2604419714 creator A5053568782 @default.
- W2604419714 creator A5055082899 @default.
- W2604419714 creator A5073399193 @default.
- W2604419714 creator A5073720321 @default.
- W2604419714 creator A5079719834 @default.
- W2604419714 creator A5080320018 @default.
- W2604419714 creator A5086853862 @default.
- W2604419714 date "2017-04-05" @default.
- W2604419714 modified "2023-10-16" @default.
- W2604419714 title "Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging" @default.
- W2604419714 cites W1580261433 @default.
- W2604419714 cites W1587359488 @default.
- W2604419714 cites W1637971961 @default.
- W2604419714 cites W1965327379 @default.
- W2604419714 cites W1966955632 @default.
- W2604419714 cites W1971065968 @default.
- W2604419714 cites W1971743791 @default.
- W2604419714 cites W1975317427 @default.
- W2604419714 cites W1977836182 @default.
- W2604419714 cites W1980473459 @default.
- W2604419714 cites W1983457831 @default.
- W2604419714 cites W1983881786 @default.
- W2604419714 cites W1990095603 @default.
- W2604419714 cites W1991085215 @default.
- W2604419714 cites W1995734405 @default.
- W2604419714 cites W1996719014 @default.
- W2604419714 cites W1996822329 @default.
- W2604419714 cites W2001090820 @default.
- W2604419714 cites W2007576186 @default.
- W2604419714 cites W2010321956 @default.
- W2604419714 cites W2016666546 @default.
- W2604419714 cites W2019654241 @default.
- W2604419714 cites W2020843850 @default.
- W2604419714 cites W2031481579 @default.
- W2604419714 cites W2032297237 @default.
- W2604419714 cites W2033468788 @default.
- W2604419714 cites W2035600501 @default.
- W2604419714 cites W2042971659 @default.
- W2604419714 cites W2053680491 @default.
- W2604419714 cites W2059620954 @default.
- W2604419714 cites W2061337207 @default.
- W2604419714 cites W2064730183 @default.
- W2604419714 cites W2069506489 @default.
- W2604419714 cites W2070382843 @default.
- W2604419714 cites W2083481977 @default.
- W2604419714 cites W2089254955 @default.
- W2604419714 cites W2095606723 @default.
- W2604419714 cites W2101517369 @default.
- W2604419714 cites W2113628166 @default.
- W2604419714 cites W2136371358 @default.
- W2604419714 cites W2151669146 @default.
- W2604419714 cites W2152571442 @default.
- W2604419714 cites W2159664830 @default.
- W2604419714 cites W2160585483 @default.
- W2604419714 cites W2163865122 @default.
- W2604419714 cites W2168083679 @default.
- W2604419714 cites W2190263524 @default.
- W2604419714 cites W2194902473 @default.
- W2604419714 cites W2262353981 @default.
- W2604419714 cites W2272096593 @default.
- W2604419714 cites W2303915425 @default.
- W2604419714 cites W2320016798 @default.
- W2604419714 cites W2334033949 @default.
- W2604419714 cites W2346764160 @default.
- W2604419714 cites W2401100491 @default.
- W2604419714 cites W2471326945 @default.
- W2604419714 cites W2506776793 @default.
- W2604419714 cites W2582620106 @default.
- W2604419714 cites W4211061743 @default.
- W2604419714 cites W4232074196 @default.
- W2604419714 doi "https://doi.org/10.3390/ijms18040768" @default.
- W2604419714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5412352" @default.
- W2604419714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28379199" @default.
- W2604419714 hasPublicationYear "2017" @default.
- W2604419714 type Work @default.
- W2604419714 sameAs 2604419714 @default.
- W2604419714 citedByCount "11" @default.
- W2604419714 countsByYear W26044197142017 @default.
- W2604419714 countsByYear W26044197142018 @default.
- W2604419714 countsByYear W26044197142019 @default.
- W2604419714 countsByYear W26044197142020 @default.
- W2604419714 countsByYear W26044197142021 @default.
- W2604419714 countsByYear W26044197142022 @default.
- W2604419714 crossrefType "journal-article" @default.
- W2604419714 hasAuthorship W2604419714A5001999246 @default.
- W2604419714 hasAuthorship W2604419714A5012059772 @default.
- W2604419714 hasAuthorship W2604419714A5053568782 @default.
- W2604419714 hasAuthorship W2604419714A5055082899 @default.
- W2604419714 hasAuthorship W2604419714A5073399193 @default.
- W2604419714 hasAuthorship W2604419714A5073720321 @default.
- W2604419714 hasAuthorship W2604419714A5079719834 @default.
- W2604419714 hasAuthorship W2604419714A5080320018 @default.
- W2604419714 hasAuthorship W2604419714A5086853862 @default.
- W2604419714 hasBestOaLocation W26044197141 @default.