Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604463417> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2604463417 abstract "Abnormal calcium (Ca) cycling conditions in cardiac myocytes have been identified as a major contributor to lethal cardiac arrhythmias that lead to sudden cardiac death. Under these conditions, Ca waves can emerge spontaneously from within the subcellular Ca release unit (CRU) network in Ca overloaded myocytes and facilitate the formation of delayed afterdepolarization (DAD) and early afterdepolarization (EAD) arrhythmia triggers at the cellular scale. Whether DADs and EADs can overcome the electronic sink effect of resting neighboring myocytes to propagate and disrupt the normal conduction of action potentials in cardiac tissue highly depends upon the timing and spatial organization of myocytes exhibiting spontaneous Ca waves. The exact mechanisms that govern these events are still under much debate and not fully understood. The goal of our studies in this body of work is two-fold. The first is to understand how a broad spectrum of spontaneous Ca release events, including Ca waves, are able to emerge collectively from within the CRU network. The second is to understand how the effects of subcellular Ca release events traverse scales to influence the morphology of DADs and EADs at the cellular scale and promote arrhythmias at the tissue scale. In order to achieve these ends, we have utilized a multidisciplinary approach that draws upon and integrates ideas, concepts, and techniques largely from experimental electrophysiology, nonlinear dynamics, and mathematical modeling. This approach has allowed tremendous versatility in the way arrhythmias can be conceptualized, quantitatively assessed, and logically predicted. As such, we have discovered a universal mechanism of criticality that governs the transition from stochastic Ca sparks to deterministic Ca waves, a general theory for Ca wave entrainment that can explain subcellular pacemaker site emergence, novel complex EAD morphologies that emerge due to the interaction between the stochastic effects of subcellular Ca release and the deterministic relationships among voltage-gated ion channels, that the distribution of latencies to the onset of Ca waves among myocytes is the most important factor promoting DADs in cardiac tissue, and that DADs and EADs can promote arrhythmias not only by generating triggers but by enhancing tissue substrate vulnerability." @default.
- W2604463417 created "2017-04-14" @default.
- W2604463417 creator A5064941834 @default.
- W2604463417 date "2016-01-01" @default.
- W2604463417 modified "2023-09-27" @default.
- W2604463417 title "The Dynamical Emergence of Calcium-Mediated Arrhythmias from the Subcellular Calcium Release Unit Network" @default.
- W2604463417 hasPublicationYear "2016" @default.
- W2604463417 type Work @default.
- W2604463417 sameAs 2604463417 @default.
- W2604463417 citedByCount "0" @default.
- W2604463417 crossrefType "journal-article" @default.
- W2604463417 hasAuthorship W2604463417A5064941834 @default.
- W2604463417 hasConcept C113217602 @default.
- W2604463417 hasConcept C12554922 @default.
- W2604463417 hasConcept C126322002 @default.
- W2604463417 hasConcept C146403970 @default.
- W2604463417 hasConcept C155730078 @default.
- W2604463417 hasConcept C169760540 @default.
- W2604463417 hasConcept C185263204 @default.
- W2604463417 hasConcept C185592680 @default.
- W2604463417 hasConcept C195221683 @default.
- W2604463417 hasConcept C201571599 @default.
- W2604463417 hasConcept C207200792 @default.
- W2604463417 hasConcept C3018686881 @default.
- W2604463417 hasConcept C519063684 @default.
- W2604463417 hasConcept C71924100 @default.
- W2604463417 hasConcept C86803240 @default.
- W2604463417 hasConcept C95444343 @default.
- W2604463417 hasConceptScore W2604463417C113217602 @default.
- W2604463417 hasConceptScore W2604463417C12554922 @default.
- W2604463417 hasConceptScore W2604463417C126322002 @default.
- W2604463417 hasConceptScore W2604463417C146403970 @default.
- W2604463417 hasConceptScore W2604463417C155730078 @default.
- W2604463417 hasConceptScore W2604463417C169760540 @default.
- W2604463417 hasConceptScore W2604463417C185263204 @default.
- W2604463417 hasConceptScore W2604463417C185592680 @default.
- W2604463417 hasConceptScore W2604463417C195221683 @default.
- W2604463417 hasConceptScore W2604463417C201571599 @default.
- W2604463417 hasConceptScore W2604463417C207200792 @default.
- W2604463417 hasConceptScore W2604463417C3018686881 @default.
- W2604463417 hasConceptScore W2604463417C519063684 @default.
- W2604463417 hasConceptScore W2604463417C71924100 @default.
- W2604463417 hasConceptScore W2604463417C86803240 @default.
- W2604463417 hasConceptScore W2604463417C95444343 @default.
- W2604463417 hasLocation W26044634171 @default.
- W2604463417 hasOpenAccess W2604463417 @default.
- W2604463417 hasPrimaryLocation W26044634171 @default.
- W2604463417 hasRelatedWork W159743246 @default.
- W2604463417 hasRelatedWork W1964587922 @default.
- W2604463417 hasRelatedWork W1972051771 @default.
- W2604463417 hasRelatedWork W1972249839 @default.
- W2604463417 hasRelatedWork W1976509282 @default.
- W2604463417 hasRelatedWork W1980938039 @default.
- W2604463417 hasRelatedWork W2005865511 @default.
- W2604463417 hasRelatedWork W2014094555 @default.
- W2604463417 hasRelatedWork W2026260067 @default.
- W2604463417 hasRelatedWork W2028858184 @default.
- W2604463417 hasRelatedWork W2037899064 @default.
- W2604463417 hasRelatedWork W2050121617 @default.
- W2604463417 hasRelatedWork W2056108584 @default.
- W2604463417 hasRelatedWork W2064983993 @default.
- W2604463417 hasRelatedWork W2084515554 @default.
- W2604463417 hasRelatedWork W2101242392 @default.
- W2604463417 hasRelatedWork W2167143533 @default.
- W2604463417 hasRelatedWork W2520208127 @default.
- W2604463417 hasRelatedWork W2766747401 @default.
- W2604463417 hasRelatedWork W2898206181 @default.
- W2604463417 isParatext "false" @default.
- W2604463417 isRetracted "false" @default.
- W2604463417 magId "2604463417" @default.
- W2604463417 workType "article" @default.