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• W2604504890 abstract "Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A–C (1–3), along with (±)-5,4′-dihydroxy-2′-methoxy-6′,6″-dimethypyraro-(2″,3″:7,8)-6-methyflavanone (4), and ((2S)-5,7,4′-trihydroxy-2′-methoxy-8,5′-di(3-methyl-2-butenyl)-6-methylflavanone (5). Structures of the compounds 1–5 were elucidated using spectroscopic techniques, such as UV, IR, NMR (1D and 2D), and HRESI-MS. Tripteryols B (2) was found active in the antimicrobial assay against Cryptococcus neoformans, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with IC50 values in the range of 2.95–8.59 μg/mL. Compounds 4 and 5 showed significant antimicrobial activities against C. neoformans, MRSA and Staphylococcus aureus with IC50 values in the range of 1.06–2.60 μg/mL. Additionally, significant antimalarial activities of tripteryols A–B (1–2) against chloroquine-sensitive D6 and resistant W2 clones of Plasmodium falciparum were observed and none of the compounds 1–5 were cytotoxic to Vero cells." @default.
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• W2604504890 date "2017-06-01" @default.
• W2604504890 modified "2023-10-17" @default.
• W2604504890 title "Prenylated flavonoids from the stems and roots of Tripterygium wilfordii" @default.
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• W2604504890 doi "https://doi.org/10.1016/j.fitote.2017.04.003" @default.
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