Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604549705> ?p ?o ?g. }
- W2604549705 endingPage "3802" @default.
- W2604549705 startingPage "3796" @default.
- W2604549705 abstract "Kupffer cells (KCs) influence liver allografts by interacting with other non‑parenchymal cells. However, the exact mechanism remains unclear. Upregulation of heme oxygenase-1 (HO-1) in KCs upon interaction with mast cells (MCs), and the effects on dendritic cell (DC) function, were investigated in the present study. KCs, MCs and DCs were prepared from 8‑10‑week‑old C57BL/6 mice. KCs were pretreated with PBS, dimethyl sulfoxide, hemin (50 µM; HO‑1 inducer), and zinc protoporphyrin (50 µM; HO‑1 inhibitor) for 8 h. Reverse transcription‑polymerase chain reaction and western blotting was performed to determine HO‑1 mRNA and protein levels in KCs, respectively. C‑C motif chemokine receptor 7 (CCR7) surface molecules were measured using flow cytometry, and prostaglandin E2 (PGE2), C‑C motif chemokine ligand (CCL) 19 and CCL21 were measured by ELISA. The Transwell model was used to investigate the migration of DCs. Pretreatment of KCs with hemin induced HO‑1 transcription and protein expression, and interacted with and stabilized MC membranes. When co‑cultured with MCs, the expression of CCR7 on DCs was reduced, and PGE2, CCL19 and CCL21 were similarly decreased. DC migration was also impaired. Upregulation of HO‑1 in KCs blocked MC degranulation and reduced DC migration." @default.
- W2604549705 created "2017-04-14" @default.
- W2604549705 creator A5004981617 @default.
- W2604549705 creator A5023810650 @default.
- W2604549705 creator A5041258331 @default.
- W2604549705 creator A5073663977 @default.
- W2604549705 creator A5074243377 @default.
- W2604549705 creator A5079808010 @default.
- W2604549705 creator A5086543573 @default.
- W2604549705 creator A5091122364 @default.
- W2604549705 date "2017-04-07" @default.
- W2604549705 modified "2023-10-14" @default.
- W2604549705 title "Upregulation of heme oxygenase-1 in Kupffer cells blocks mast cell degranulation and inhibits dendritic cell migration in vitro" @default.
- W2604549705 cites W1575342577 @default.
- W2604549705 cites W1593183731 @default.
- W2604549705 cites W1965069792 @default.
- W2604549705 cites W1969734421 @default.
- W2604549705 cites W1970598946 @default.
- W2604549705 cites W1973081785 @default.
- W2604549705 cites W1974541014 @default.
- W2604549705 cites W1975371419 @default.
- W2604549705 cites W1984512893 @default.
- W2604549705 cites W1985193797 @default.
- W2604549705 cites W1987387371 @default.
- W2604549705 cites W1999560648 @default.
- W2604549705 cites W2003566453 @default.
- W2604549705 cites W2004442139 @default.
- W2604549705 cites W2013177380 @default.
- W2604549705 cites W2023668858 @default.
- W2604549705 cites W2027207867 @default.
- W2604549705 cites W2028509244 @default.
- W2604549705 cites W2033172475 @default.
- W2604549705 cites W2034222095 @default.
- W2604549705 cites W2040479226 @default.
- W2604549705 cites W2064754666 @default.
- W2604549705 cites W2069220094 @default.
- W2604549705 cites W2076462567 @default.
- W2604549705 cites W2087232111 @default.
- W2604549705 cites W2092631285 @default.
- W2604549705 cites W2093342110 @default.
- W2604549705 cites W2107277218 @default.
- W2604549705 cites W2107525560 @default.
- W2604549705 cites W2131706494 @default.
- W2604549705 cites W2132306737 @default.
- W2604549705 cites W2135462268 @default.
- W2604549705 cites W2140918433 @default.
- W2604549705 cites W2149057253 @default.
- W2604549705 cites W2160896412 @default.
- W2604549705 cites W2329850288 @default.
- W2604549705 doi "https://doi.org/10.3892/mmr.2017.6448" @default.
- W2604549705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28393189" @default.
- W2604549705 hasPublicationYear "2017" @default.
- W2604549705 type Work @default.
- W2604549705 sameAs 2604549705 @default.
- W2604549705 citedByCount "5" @default.
- W2604549705 countsByYear W26045497052018 @default.
- W2604549705 countsByYear W26045497052020 @default.
- W2604549705 countsByYear W26045497052021 @default.
- W2604549705 countsByYear W26045497052022 @default.
- W2604549705 countsByYear W26045497052023 @default.
- W2604549705 crossrefType "journal-article" @default.
- W2604549705 hasAuthorship W2604549705A5004981617 @default.
- W2604549705 hasAuthorship W2604549705A5023810650 @default.
- W2604549705 hasAuthorship W2604549705A5041258331 @default.
- W2604549705 hasAuthorship W2604549705A5073663977 @default.
- W2604549705 hasAuthorship W2604549705A5074243377 @default.
- W2604549705 hasAuthorship W2604549705A5079808010 @default.
- W2604549705 hasAuthorship W2604549705A5086543573 @default.
- W2604549705 hasAuthorship W2604549705A5091122364 @default.
- W2604549705 hasBestOaLocation W26045497051 @default.
- W2604549705 hasConcept C104317684 @default.
- W2604549705 hasConcept C127561419 @default.
- W2604549705 hasConcept C127801297 @default.
- W2604549705 hasConcept C12823836 @default.
- W2604549705 hasConcept C13373296 @default.
- W2604549705 hasConcept C153911025 @default.
- W2604549705 hasConcept C170493617 @default.
- W2604549705 hasConcept C181199279 @default.
- W2604549705 hasConcept C185592680 @default.
- W2604549705 hasConcept C2776217839 @default.
- W2604549705 hasConcept C2778049957 @default.
- W2604549705 hasConcept C2779219270 @default.
- W2604549705 hasConcept C2781447869 @default.
- W2604549705 hasConcept C49802076 @default.
- W2604549705 hasConcept C55493867 @default.
- W2604549705 hasConcept C86803240 @default.
- W2604549705 hasConcept C95444343 @default.
- W2604549705 hasConceptScore W2604549705C104317684 @default.
- W2604549705 hasConceptScore W2604549705C127561419 @default.
- W2604549705 hasConceptScore W2604549705C127801297 @default.
- W2604549705 hasConceptScore W2604549705C12823836 @default.
- W2604549705 hasConceptScore W2604549705C13373296 @default.
- W2604549705 hasConceptScore W2604549705C153911025 @default.
- W2604549705 hasConceptScore W2604549705C170493617 @default.
- W2604549705 hasConceptScore W2604549705C181199279 @default.
- W2604549705 hasConceptScore W2604549705C185592680 @default.
- W2604549705 hasConceptScore W2604549705C2776217839 @default.
- W2604549705 hasConceptScore W2604549705C2778049957 @default.