Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604557960> ?p ?o ?g. }
- W2604557960 endingPage "74" @default.
- W2604557960 startingPage "74" @default.
- W2604557960 abstract "Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder that often occurs in patients with asthma or cystic fibrosis (CF) and is characterized by a hypersensitivity response to the allergens of the fungus Aspergillus fumigatus. In patients with CF, growth of A. fumigatus hyphae within the bronchial lumen triggers an immunoglobulin E (IgE)-mediated hypersensitivity response that results in airway inflammation, bronchospasm, and bronchiectasis. In most published studies, the prevalence of ABPA is about 8.9% in patients with CF. Since the clinical features of this condition overlap significantly with that of CF, ABPA is challenging to diagnose and remains underdiagnosed in many patients. Diagnosis of ABPA in CF patients should be sought in those with evidence of clinical and radiologic deterioration that is not attributable to another etiology, a markedly elevated total serum IgE level (while off steroid therapy) and evidence of A. fumigatus sensitization. Management of ABPA involves the use of systemic steroids to reduce inflammation and modulate the immune response. In patients who do not respond to steroids or cannot tolerate them, antifungal agents should be used to reduce the burden of A. fumigatus allergens. Recent studies suggest that omalizumab may be an effective option to reduce the frequency of ABPA exacerbations in patients with CF. Further randomized controlled trials are needed to better establish the efficacy of omalizumab in managing patients with CF and ABPA." @default.
- W2604557960 created "2017-04-14" @default.
- W2604557960 creator A5015746267 @default.
- W2604557960 creator A5039027005 @default.
- W2604557960 creator A5040263578 @default.
- W2604557960 date "2017-01-01" @default.
- W2604557960 modified "2023-09-26" @default.
- W2604557960 title "Allergic bronchopulmonary aspergillosis in patients with cystic fibrosis" @default.
- W2604557960 cites W1501205955 @default.
- W2604557960 cites W1516867939 @default.
- W2604557960 cites W1538211916 @default.
- W2604557960 cites W1569469199 @default.
- W2604557960 cites W1581392104 @default.
- W2604557960 cites W1749084180 @default.
- W2604557960 cites W182894452 @default.
- W2604557960 cites W1857079041 @default.
- W2604557960 cites W1895204403 @default.
- W2604557960 cites W1913132711 @default.
- W2604557960 cites W1926480320 @default.
- W2604557960 cites W1951252417 @default.
- W2604557960 cites W1963790115 @default.
- W2604557960 cites W1969023513 @default.
- W2604557960 cites W1969971789 @default.
- W2604557960 cites W1972387926 @default.
- W2604557960 cites W1980936990 @default.
- W2604557960 cites W1982686853 @default.
- W2604557960 cites W1985197573 @default.
- W2604557960 cites W1985927542 @default.
- W2604557960 cites W1988235488 @default.
- W2604557960 cites W1989823290 @default.
- W2604557960 cites W1989990623 @default.
- W2604557960 cites W1993693257 @default.
- W2604557960 cites W1996739651 @default.
- W2604557960 cites W1999816913 @default.
- W2604557960 cites W2002434493 @default.
- W2604557960 cites W2006376408 @default.
- W2604557960 cites W2007255271 @default.
- W2604557960 cites W2008687568 @default.
- W2604557960 cites W2012767918 @default.
- W2604557960 cites W2013471193 @default.
- W2604557960 cites W2015849091 @default.
- W2604557960 cites W2018940868 @default.
- W2604557960 cites W2029038776 @default.
- W2604557960 cites W2029712882 @default.
- W2604557960 cites W2033391872 @default.
- W2604557960 cites W2034954123 @default.
- W2604557960 cites W2035606995 @default.
- W2604557960 cites W2036044424 @default.
- W2604557960 cites W2038986380 @default.
- W2604557960 cites W2039587706 @default.
- W2604557960 cites W2044746182 @default.
- W2604557960 cites W2056380314 @default.
- W2604557960 cites W2059474954 @default.
- W2604557960 cites W2059497665 @default.
- W2604557960 cites W2062560903 @default.
- W2604557960 cites W2067100404 @default.
- W2604557960 cites W2067176929 @default.
- W2604557960 cites W2067212537 @default.
- W2604557960 cites W2073476576 @default.
- W2604557960 cites W2076741481 @default.
- W2604557960 cites W2077424676 @default.
- W2604557960 cites W2078169140 @default.
- W2604557960 cites W2080662910 @default.
- W2604557960 cites W2082729472 @default.
- W2604557960 cites W2083008620 @default.
- W2604557960 cites W2085610341 @default.
- W2604557960 cites W2088624642 @default.
- W2604557960 cites W2091884215 @default.
- W2604557960 cites W2096728005 @default.
- W2604557960 cites W2099318155 @default.
- W2604557960 cites W2112670807 @default.
- W2604557960 cites W2114074659 @default.
- W2604557960 cites W2115511578 @default.
- W2604557960 cites W2117134588 @default.
- W2604557960 cites W2121500558 @default.
- W2604557960 cites W2129228230 @default.
- W2604557960 cites W2131925328 @default.
- W2604557960 cites W2135649656 @default.
- W2604557960 cites W2136496779 @default.
- W2604557960 cites W2138701561 @default.
- W2604557960 cites W2139627695 @default.
- W2604557960 cites W2146328954 @default.
- W2604557960 cites W2151026810 @default.
- W2604557960 cites W2152398817 @default.
- W2604557960 cites W2153911335 @default.
- W2604557960 cites W2156755613 @default.
- W2604557960 cites W2157832139 @default.
- W2604557960 cites W2158676024 @default.
- W2604557960 cites W2160560475 @default.
- W2604557960 cites W2163665700 @default.
- W2604557960 cites W2164252368 @default.
- W2604557960 cites W2164891490 @default.
- W2604557960 cites W2171744559 @default.
- W2604557960 cites W2172561389 @default.
- W2604557960 cites W2173634416 @default.
- W2604557960 cites W2260747993 @default.
- W2604557960 cites W2279804527 @default.
- W2604557960 cites W2316520860 @default.