Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604595989> ?p ?o ?g. }
- W2604595989 endingPage "9305" @default.
- W2604595989 startingPage "9297" @default.
- W2604595989 abstract "Abstract The rational design of a well‐defined protein‐like tertiary structure formed by small peptide building blocks is still a formidable challenge. By using peptide–oligonucleotide conjugates (POC) as building blocks, we present the self‐assembly of miniature coiled‐coil α‐helical peptides guided by oligonucleotide duplex and triplex formation. POC synthesis was achieved by copper‐free alkyne–azide cycloaddition between three oligonucleotides and a 23‐mer peptide, which by itself exhibited multiple oligomeric states in solution. The oligonucleotide domain was designed to furnish a stable parallel triplex under physiological pH, and to be capable of templating the three peptide sequences to constitute a small coiled‐coil motif displaying remarkable α‐helicity. The formed trimeric complex was characterized by ultraviolet thermal denaturation, gel electrophoresis, circular dichroism (CD) spectroscopy, small‐angle X‐ray scattering (SAXS), and molecular modeling. Stabilizing cooperativity was observed between the trimeric peptide and the oligonucleotide triplex domains, and the overall molecular size (ca. 12 nm) in solution was revealed to be independent of concentration. The topological folding of the peptide moiety differed strongly from those of the individual POC strands and the unconjugated peptide, exclusively adopting the designed triple helical structure." @default.
- W2604595989 created "2017-04-14" @default.
- W2604595989 creator A5016458276 @default.
- W2604595989 creator A5017339782 @default.
- W2604595989 creator A5032521031 @default.
- W2604595989 creator A5035519916 @default.
- W2604595989 creator A5053745370 @default.
- W2604595989 creator A5053892458 @default.
- W2604595989 creator A5054790786 @default.
- W2604595989 creator A5084599077 @default.
- W2604595989 creator A5091308505 @default.
- W2604595989 date "2017-05-10" @default.
- W2604595989 modified "2023-10-11" @default.
- W2604595989 title "Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex" @default.
- W2604595989 cites W1539200107 @default.
- W2604595989 cites W1563988826 @default.
- W2604595989 cites W1691401846 @default.
- W2604595989 cites W1794170378 @default.
- W2604595989 cites W1930540356 @default.
- W2604595989 cites W1976499671 @default.
- W2604595989 cites W1978190597 @default.
- W2604595989 cites W2004396117 @default.
- W2604595989 cites W2007736465 @default.
- W2604595989 cites W2008686601 @default.
- W2604595989 cites W2010931041 @default.
- W2604595989 cites W2011726533 @default.
- W2604595989 cites W2012778514 @default.
- W2604595989 cites W2019403558 @default.
- W2604595989 cites W2024296243 @default.
- W2604595989 cites W2029667189 @default.
- W2604595989 cites W2032155561 @default.
- W2604595989 cites W2034051387 @default.
- W2604595989 cites W2034453889 @default.
- W2604595989 cites W2041026060 @default.
- W2604595989 cites W2043514891 @default.
- W2604595989 cites W2043951705 @default.
- W2604595989 cites W2063030872 @default.
- W2604595989 cites W2066907250 @default.
- W2604595989 cites W2080386842 @default.
- W2604595989 cites W2082433496 @default.
- W2604595989 cites W2086598566 @default.
- W2604595989 cites W2094524922 @default.
- W2604595989 cites W2102359170 @default.
- W2604595989 cites W2117552063 @default.
- W2604595989 cites W2117781847 @default.
- W2604595989 cites W2119970960 @default.
- W2604595989 cites W2123017921 @default.
- W2604595989 cites W2133641393 @default.
- W2604595989 cites W2137825587 @default.
- W2604595989 cites W2137986227 @default.
- W2604595989 cites W2139616692 @default.
- W2604595989 cites W2151323671 @default.
- W2604595989 cites W2153228625 @default.
- W2604595989 cites W2153375254 @default.
- W2604595989 cites W2157377686 @default.
- W2604595989 cites W2160333266 @default.
- W2604595989 cites W2165598995 @default.
- W2604595989 cites W2166498854 @default.
- W2604595989 cites W2287039621 @default.
- W2604595989 cites W2287978221 @default.
- W2604595989 cites W2330720290 @default.
- W2604595989 cites W2333811465 @default.
- W2604595989 cites W2346627216 @default.
- W2604595989 cites W2415388328 @default.
- W2604595989 cites W2433650340 @default.
- W2604595989 cites W2468002626 @default.
- W2604595989 cites W2473622490 @default.
- W2604595989 cites W2478916062 @default.
- W2604595989 cites W2517316787 @default.
- W2604595989 cites W2519539312 @default.
- W2604595989 cites W4231634001 @default.
- W2604595989 cites W4238327249 @default.
- W2604595989 cites W4243951542 @default.
- W2604595989 cites W4247601507 @default.
- W2604595989 cites W4254121907 @default.
- W2604595989 cites W4362235795 @default.
- W2604595989 doi "https://doi.org/10.1002/chem.201700971" @default.
- W2604595989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28383784" @default.
- W2604595989 hasPublicationYear "2017" @default.
- W2604595989 type Work @default.
- W2604595989 sameAs 2604595989 @default.
- W2604595989 citedByCount "12" @default.
- W2604595989 countsByYear W26045959892018 @default.
- W2604595989 countsByYear W26045959892019 @default.
- W2604595989 countsByYear W26045959892020 @default.
- W2604595989 countsByYear W26045959892021 @default.
- W2604595989 countsByYear W26045959892022 @default.
- W2604595989 countsByYear W26045959892023 @default.
- W2604595989 crossrefType "journal-article" @default.
- W2604595989 hasAuthorship W2604595989A5016458276 @default.
- W2604595989 hasAuthorship W2604595989A5017339782 @default.
- W2604595989 hasAuthorship W2604595989A5032521031 @default.
- W2604595989 hasAuthorship W2604595989A5035519916 @default.
- W2604595989 hasAuthorship W2604595989A5053745370 @default.
- W2604595989 hasAuthorship W2604595989A5053892458 @default.
- W2604595989 hasAuthorship W2604595989A5054790786 @default.
- W2604595989 hasAuthorship W2604595989A5084599077 @default.
- W2604595989 hasAuthorship W2604595989A5091308505 @default.