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- W2604636505 abstract "As we predicted, hypercholesterolemic diet had no effect on theactivity of hepatic CYP4501A2 isoenzyme and concentrations ofmarker PHEN and its metabolite PAR were comparable incholesterol and control animals. Our opinion is that the onlyeffect of long-lasting hypercholesterolemic diet on theactivity of CYP can be caused by hepatic steatosis ofhepatocytes and thus a decrease of their metabolic activity.Administration of polyphenolic extract caused induction ofCYP1A2 isoenzyme and was manifested as increased levels of PARin perfusion medium during the whole perfusion. One shouldexpect that inducers of CYP isoform would cause in the treatedanimals an increase in metabolite levels compared to thecontrols while levels of markers are reversely increased incontrols and decreased in treated groups. In our case howeveradministration of polyphenolic extract lead to statisticallysignificant increase of both, PAR and PHEN in the 30th minuteof perfusion. In our opinion, this can be caused by the changesin the binding capacity of liver for PHEN, as liver of controlrats showed rather a big portion of PHEN bound, too. Ourresults suggest, that administration of polyphenolic extractchanges the activity of CYP1A2, but on the contrary to theresults of other authors, acts as an inductor of CYP1A2 andthus can accelerate activation of specific procarcinogensmetabolized by this hepatic isoenzyme. Further investigationshould be processed to explain the increased level of PHEN inthe 30th minute of perfusion." @default.
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- W2604636505 date "2007-01-01" @default.
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- W2604636505 title "The influence of diet on metabolic activity of cytochrome P450" @default.
- W2604636505 hasPublicationYear "2007" @default.
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