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• W2604645848 abstract "Over the last couple of decades, a demographic transition towards an aging population has occurred. This has been accompanied by an increase in chronic inflammatory disorders like atopic dermatitis, rheumatoid arthritis, and diabetic ulcers, as many of these are strongly age related. There is thus an increasing demand to develop better therapeutic strategies to manage and cure chronic diseases. In many of these diseases, the trigger for onset of the inflammation is diverse, but their chronic, non-resolving phases share many similarities like, e.g. composition of the cellular infiltrate and cytokine milieu. One of the main constituents of the cellular infiltrate are macrophages (MØs), and these have been recognised as key players in chronicity. In particular, the pro-inflammatory M1 subpopulations has been ascribed a role in persistence, whereas the M2 population is involved in tissue remodeling and resolution. The high expression of the high affinity receptor for IgG is specific for M1. In this chapter, we describe the preclinical development of immunotoxins, targeting CD64 on M1, for the treatment of the chronic phase of chronic inflammatory diseases. Although ADCs using a protein toxin as effector molecule, also known as immunotoxins, were mainly developed for life-threatening disease like cancer, the ongoing improvement on these therapeutics has broadened their potential clinical application. Preclinical data on immunotoxins targeting CD64 show that targeting M1 cells through CD64 in chronic inflammation has a beneficial effect on course and development of the disease and leads to resolution of the inflammation, both in vivo in preclinical animal models and ex vivo on patient-derived cells and biopsies. This efficacy, combined with the improved safety profile of the latest generation immunotoxins, qualifies these CD64-targeted agents for M1-specific therapeutic intervention in chronic inflammatory disease." @default.
• W2604645848 created "2017-04-14" @default.
• W2604645848 creator A5009687648 @default.
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• W2604645848 date "2017-01-01" @default.
• W2604645848 modified "2023-09-26" @default.
• W2604645848 title "Recombinant Immunotoxins for Chronic Inflammatory Disease" @default.
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• W2604645848 doi "https://doi.org/10.1007/978-3-319-46877-8_7" @default.
• W2604645848 hasPublicationYear "2017" @default.
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