Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604651567> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2604651567 abstract "Diabetic nephropathy (DN) is one of the most common and seriouscomplications of diabetes mellitus with pathological activationof renin-angiotensin-aldosterone system (RAAS) as the keypathogenetic mechanism. Pharmacological blockade of RAASrepresents the main renoprotective treatment of DN. Severalsingle nucleotide polymorphisms (SNPs) were shown to influenceinterindividual variability of RAAS (e.g circulating levels ofRAAS compounds and enzyme activities). These functional geneticvariants are supposed to modify therapeutic effect of RAASblockers. Genetic variability together with other factors,which are objects of therapeutical compensation (e.g.glycaemia, blood pressure, proteinuria, lipidaemia and bodyweight) can affect progression of kidney damage in diabetics.The aim of this project is to study the effect of geneticvariability in the selected components of RAAS in theprogression of kidney disease by diabetic patients. Three SNPsin angiotensin converting enzyme (ACE - rs4343),angiotensinogen (ATG M235T - rs699) and angiotensin II type Ireceptor gene (ATR1 A1166C - rs5186) were genotyped usingrestriction fragment length polymorphism PCR. This case – casestudy involved 433 patients with a different degree of DN.Results of the haplotype analysis will be compared with apharmacological treatment - especially RAAS blockers. We expecta variability of haplotypes in RAAS genes among patients withdifferent degree of DN and a possibility of an implementationof phamacogenomic approach to the treatment of DN." @default.
- W2604651567 created "2017-04-14" @default.
- W2604651567 creator A5016492941 @default.
- W2604651567 creator A5016505714 @default.
- W2604651567 creator A5031120352 @default.
- W2604651567 creator A5038317007 @default.
- W2604651567 creator A5045279157 @default.
- W2604651567 creator A5047885441 @default.
- W2604651567 date "2011-01-01" @default.
- W2604651567 modified "2023-10-18" @default.
- W2604651567 title "Diabetic nephropathy - Pharmacogenomics and variability ingenes of renin-angiotensin-aledosterone system" @default.
- W2604651567 hasPublicationYear "2011" @default.
- W2604651567 type Work @default.
- W2604651567 sameAs 2604651567 @default.
- W2604651567 citedByCount "0" @default.
- W2604651567 crossrefType "journal-article" @default.
- W2604651567 hasAuthorship W2604651567A5016492941 @default.
- W2604651567 hasAuthorship W2604651567A5016505714 @default.
- W2604651567 hasAuthorship W2604651567A5031120352 @default.
- W2604651567 hasAuthorship W2604651567A5038317007 @default.
- W2604651567 hasAuthorship W2604651567A5045279157 @default.
- W2604651567 hasAuthorship W2604651567A5047885441 @default.
- W2604651567 hasConcept C104317684 @default.
- W2604651567 hasConcept C126322002 @default.
- W2604651567 hasConcept C134018914 @default.
- W2604651567 hasConcept C135763542 @default.
- W2604651567 hasConcept C153209595 @default.
- W2604651567 hasConcept C170734499 @default.
- W2604651567 hasConcept C197754878 @default.
- W2604651567 hasConcept C198710026 @default.
- W2604651567 hasConcept C27016395 @default.
- W2604651567 hasConcept C2779922275 @default.
- W2604651567 hasConcept C2781184683 @default.
- W2604651567 hasConcept C54355233 @default.
- W2604651567 hasConcept C555293320 @default.
- W2604651567 hasConcept C60644358 @default.
- W2604651567 hasConcept C71924100 @default.
- W2604651567 hasConcept C84393581 @default.
- W2604651567 hasConcept C86803240 @default.
- W2604651567 hasConcept C98274493 @default.
- W2604651567 hasConceptScore W2604651567C104317684 @default.
- W2604651567 hasConceptScore W2604651567C126322002 @default.
- W2604651567 hasConceptScore W2604651567C134018914 @default.
- W2604651567 hasConceptScore W2604651567C135763542 @default.
- W2604651567 hasConceptScore W2604651567C153209595 @default.
- W2604651567 hasConceptScore W2604651567C170734499 @default.
- W2604651567 hasConceptScore W2604651567C197754878 @default.
- W2604651567 hasConceptScore W2604651567C198710026 @default.
- W2604651567 hasConceptScore W2604651567C27016395 @default.
- W2604651567 hasConceptScore W2604651567C2779922275 @default.
- W2604651567 hasConceptScore W2604651567C2781184683 @default.
- W2604651567 hasConceptScore W2604651567C54355233 @default.
- W2604651567 hasConceptScore W2604651567C555293320 @default.
- W2604651567 hasConceptScore W2604651567C60644358 @default.
- W2604651567 hasConceptScore W2604651567C71924100 @default.
- W2604651567 hasConceptScore W2604651567C84393581 @default.
- W2604651567 hasConceptScore W2604651567C86803240 @default.
- W2604651567 hasConceptScore W2604651567C98274493 @default.
- W2604651567 hasLocation W26046515671 @default.
- W2604651567 hasOpenAccess W2604651567 @default.
- W2604651567 hasPrimaryLocation W26046515671 @default.
- W2604651567 hasRelatedWork W1533520604 @default.
- W2604651567 hasRelatedWork W2003291247 @default.
- W2604651567 hasRelatedWork W2007032397 @default.
- W2604651567 hasRelatedWork W2049382913 @default.
- W2604651567 hasRelatedWork W2068641163 @default.
- W2604651567 hasRelatedWork W2081767574 @default.
- W2604651567 hasRelatedWork W2081786428 @default.
- W2604651567 hasRelatedWork W2095023025 @default.
- W2604651567 hasRelatedWork W2141178151 @default.
- W2604651567 hasRelatedWork W2182814343 @default.
- W2604651567 hasRelatedWork W2297808847 @default.
- W2604651567 hasRelatedWork W2331050240 @default.
- W2604651567 hasRelatedWork W2411776817 @default.
- W2604651567 hasRelatedWork W2434196487 @default.
- W2604651567 hasRelatedWork W2806150975 @default.
- W2604651567 hasRelatedWork W2902146360 @default.
- W2604651567 hasRelatedWork W3131589484 @default.
- W2604651567 hasRelatedWork W340956748 @default.
- W2604651567 hasRelatedWork W38414658 @default.
- W2604651567 hasRelatedWork W2460335357 @default.
- W2604651567 isParatext "false" @default.
- W2604651567 isRetracted "false" @default.
- W2604651567 magId "2604651567" @default.
- W2604651567 workType "article" @default.