Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604773103> ?p ?o ?g. }
- W2604773103 endingPage "88" @default.
- W2604773103 startingPage "76" @default.
- W2604773103 abstract "Osteoarthritis is a degenerative disease of joints with destruction of articular cartilage associated with subchondral bone hypertrophy and inflammation. OA is the leading cause of joint pain resulting in significant worsening of the quality-of-life in the elderly. Numerous efforts have been spent to overcome the inherently poor healing ability of articular cartilage. Mesenchymal stem cells (MSCs) have been in the limelight of cell-based therapies to promote cartilage repair. Despite progressive advancements in MSC manipulation and the introduction of various bioactive scaffolds and growth factors in preclinical studies, current clinical trials are still at early stages with preliminary aims to evaluate safety, feasibility and efficacy. This review summarises recently reported MSC-based clinical trials and discusses new research directions with particular focus on the potential application of MSC-derived extracellular vehicles, miRNAs and advanced gene editing techniques which may shed light on the development of novel treatment strategies. The translational potential of this article: This review summarises recent MSC-related clinical research that focuses on cartilage repair. We also propose a novel possible translational direction for hyaline cartilage formation and a new paradigm making use of extra-cellular signalling and epigenetic regulation in the application of MSCs for cartilage repair." @default.
- W2604773103 created "2017-04-14" @default.
- W2604773103 creator A5019657921 @default.
- W2604773103 creator A5067298711 @default.
- W2604773103 date "2017-04-01" @default.
- W2604773103 modified "2023-10-14" @default.
- W2604773103 title "Cartilage repair by mesenchymal stem cells: Clinical trial update and perspectives" @default.
- W2604773103 cites W1197014781 @default.
- W2604773103 cites W1533281077 @default.
- W2604773103 cites W1580250799 @default.
- W2604773103 cites W1612482630 @default.
- W2604773103 cites W1650284538 @default.
- W2604773103 cites W1790126255 @default.
- W2604773103 cites W1802917769 @default.
- W2604773103 cites W1964806270 @default.
- W2604773103 cites W1967270924 @default.
- W2604773103 cites W1968746947 @default.
- W2604773103 cites W1969629712 @default.
- W2604773103 cites W1972067639 @default.
- W2604773103 cites W1984033663 @default.
- W2604773103 cites W1984367241 @default.
- W2604773103 cites W1988237668 @default.
- W2604773103 cites W1989439022 @default.
- W2604773103 cites W1992912603 @default.
- W2604773103 cites W1996482730 @default.
- W2604773103 cites W1996949698 @default.
- W2604773103 cites W1999967032 @default.
- W2604773103 cites W2000097208 @default.
- W2604773103 cites W2000511007 @default.
- W2604773103 cites W2003256954 @default.
- W2604773103 cites W2004271888 @default.
- W2604773103 cites W2011038175 @default.
- W2604773103 cites W2014359105 @default.
- W2604773103 cites W2016695470 @default.
- W2604773103 cites W2019421514 @default.
- W2604773103 cites W2021916724 @default.
- W2604773103 cites W2025371271 @default.
- W2604773103 cites W2026212186 @default.
- W2604773103 cites W2026547102 @default.
- W2604773103 cites W2028046200 @default.
- W2604773103 cites W2028089243 @default.
- W2604773103 cites W2031921408 @default.
- W2604773103 cites W2032217887 @default.
- W2604773103 cites W2036161137 @default.
- W2604773103 cites W2037155465 @default.
- W2604773103 cites W2039488563 @default.
- W2604773103 cites W2040948629 @default.
- W2604773103 cites W2044011855 @default.
- W2604773103 cites W2044237438 @default.
- W2604773103 cites W2051400613 @default.
- W2604773103 cites W2054995561 @default.
- W2604773103 cites W2055110769 @default.
- W2604773103 cites W2055424631 @default.
- W2604773103 cites W2060387475 @default.
- W2604773103 cites W2061073787 @default.
- W2604773103 cites W2066426973 @default.
- W2604773103 cites W2067716147 @default.
- W2604773103 cites W2070334783 @default.
- W2604773103 cites W2071674451 @default.
- W2604773103 cites W2077817242 @default.
- W2604773103 cites W2077836832 @default.
- W2604773103 cites W2085163273 @default.
- W2604773103 cites W2088256967 @default.
- W2604773103 cites W2089626640 @default.
- W2604773103 cites W2102884982 @default.
- W2604773103 cites W2103081715 @default.
- W2604773103 cites W2104183007 @default.
- W2604773103 cites W2104316705 @default.
- W2604773103 cites W2104454189 @default.
- W2604773103 cites W2108725095 @default.
- W2604773103 cites W2116070321 @default.
- W2604773103 cites W2116678756 @default.
- W2604773103 cites W2116833500 @default.
- W2604773103 cites W2117763379 @default.
- W2604773103 cites W2118693030 @default.
- W2604773103 cites W2119103258 @default.
- W2604773103 cites W2119376007 @default.
- W2604773103 cites W2121354606 @default.
- W2604773103 cites W2123746851 @default.
- W2604773103 cites W2127064969 @default.
- W2604773103 cites W2130187402 @default.
- W2604773103 cites W2132803736 @default.
- W2604773103 cites W2135119721 @default.
- W2604773103 cites W2139826506 @default.
- W2604773103 cites W2140084445 @default.
- W2604773103 cites W2147381804 @default.
- W2604773103 cites W2151455227 @default.
- W2604773103 cites W2154830836 @default.
- W2604773103 cites W2159542600 @default.
- W2604773103 cites W2159999899 @default.
- W2604773103 cites W2160051211 @default.
- W2604773103 cites W2160233984 @default.
- W2604773103 cites W2163273578 @default.
- W2604773103 cites W2167792025 @default.
- W2604773103 cites W2169625737 @default.
- W2604773103 cites W2170132723 @default.
- W2604773103 cites W2174154237 @default.
- W2604773103 cites W2179996559 @default.