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• W2604814157 endingPage "ar.2017.8.0191" @default.
• W2604814157 startingPage "ar.2017.8.0191" @default.
• W2604814157 abstract "Inflammatory injury of nasal respiratory mucosa is a common feature of multisystem autoimmune disease. Certain autoimmune disorders are associated with nasal septum perforation (NSP). We performed a systematic review of the literature to better understand the association of NSP with specific autoimmune disorders. This is a case report of a 29-year-old woman with a history of arthralgia, autoreactive antibody titers, platelet dysfunction, and NSP. The constellation of symptoms and potential familial involvement indicated that the NSP in this patient was an early sign of an autoimmune disorder, an unknown autoimmune disorder, or a known disease with incomplete penetrance.A systematic review of the literature was performed by two independent reviewers. Relevant articles were reviewed, and data that pertained to autoimmune-related NSP were extracted and analyzed.Overall, 140 cases of autoimmune-associated NSPs were reported. Granulomatosis with polyangiitis (48%), relapsing polychondritis (26%), and cocaine-induced midline lesions (15%) constituted 89.3% of the reported cases.NSP is a potential sign of systemic disease. The identification of an NSP, especially in the context of other unexplained symptoms or workup suggestive of an autoimmune disorder, should prompt clinical evaluation for multisystem autoimmune disease with consideration of granulomatosis with polyangiitis, relapsing polychondritis, or cocaine-induced midline lesions." @default.
• W2604814157 created "2017-04-14" @default.
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• W2604814157 date "2017-01-01" @default.
• W2604814157 modified "2023-09-27" @default.
• W2604814157 title "Autoimmune-Related Nasal Septum Perforation: A Case Report and Systematic Review" @default.
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• W2604814157 doi "https://doi.org/10.2500/ar.2017.8.0191" @default.
• W2604814157 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5380452" @default.
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