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- W2604843162 abstract "ABSTRACTIntroduction: Soft-tissue sarcomas (STS) are a diverse group of rare mesenchymal malignancies. Treatment options for advanced STS following failure of first-line chemotherapy remain limited.Areas covered: Summary of established second- or later-line regimens for advanced STS and a discussion of clinical evidence in support of eribulin use, focused on the treatment of liposarcomas and leiomyosarcomas (L-sarcomas).Expert opinion: Current evidence supporting a role for specific second-line agents in different histologic subtypes of STS is limited, but a more defined treatment landscape is emerging. Strong scientific evidence from phase 3 trials has been shown for eribulin, trabectedin, dacarbazine, and pazopanib after failure of anthracyclines. In particular, eribulin is the first systemic monotherapy to show a significant improvement in overall survival against an active comparator in a phase 3 trial in patients with advanced L-sarcomas. Eribulin is approved for the treatment of unresectable or meta..." @default.
- W2604843162 created "2017-04-14" @default.
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- W2604843162 date "2017-04-04" @default.
- W2604843162 modified "2023-10-14" @default.
- W2604843162 title "Treatment options for anthracycline-resistant, advanced soft-tissue sarcoma: the role of eribulin" @default.
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- W2604843162 doi "https://doi.org/10.1080/21678707.2017.1316190" @default.
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