FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604854931> ?p ?o ?g. }

• W2604854931 endingPage "431" @default.
• W2604854931 startingPage "415" @default.
• W2604854931 abstract "Extracellular adenosine triphosphate (ATP) binds to purinergic receptors and, as a danger molecule, promotes inflammatory responses. Here we tested whether periodate-oxidized ATP (oATP), a P2X7 receptor (P2X7R) antagonist can attenuate renal ischemia-reperfusion injury and clarify the related cellular mechanisms. Treatment with oATP prior to ischemia-reperfusion injury decreased blood urea nitrogen, serum creatinine, the tubular injury score, and tubular epithelial cell apoptosis after injury. The infiltration of dendritic cells, neutrophils, macrophages, CD69+CD4+, and CD44+CD4+ T cells was attenuated, but renal Foxp3+CD4+ Treg infiltration was increased by oATP. The levels of IL-6 and CCL2 were reduced in the oATP group. Additionally, oATP treatment following injury improved renal function, decreased the infiltration of innate and adaptive effector cells, and increased the renal infiltration of Foxp3+CD4+ Tregs. Post-ischemia-reperfusion injury oATP treatment increased tubular cell proliferation and reduced renal fibrosis. oATP treatment attenuated renal functional deterioration after ischemia-reperfusion injury in RAG-1 knockout mice; however, Treg depletion using PC61 abrogated the beneficial effects of oATP in wild-type mice. Furthermore, oATP treatment after transfer of Tregs from wild-type mice improved the beneficial effects of Tregs on ischemia-reperfusion injury, but treatment after transfer of Tregs from P2X7R knockout mice did not. Renal ischemia-reperfusion injury was also attenuated in P2X7R knockout mice. Experiments using bone marrow chimeras established that P2X7R expression on hematopoietic cells rather than non-hematopoietic cells, such as tubular epithelial cells, plays a major role in ischemia-reperfusion injury. Thus, oATP attenuated acute renal damage and facilitated renal recovery in ischemia-reperfusion injury by expansion of Tregs." @default.
• W2604854931 created "2017-04-14" @default.
• W2604854931 creator A5010110196 @default.
• W2604854931 creator A5023097709 @default.
• W2604854931 creator A5047283512 @default.
• W2604854931 creator A5051447440 @default.
• W2604854931 creator A5057361104 @default.
• W2604854931 creator A5058535138 @default.
• W2604854931 creator A5064838894 @default.
• W2604854931 creator A5079834009 @default.
• W2604854931 creator A5080009275 @default.
• W2604854931 date "2017-08-01" @default.
• W2604854931 modified "2023-10-10" @default.
• W2604854931 title "The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells" @default.
• W2604854931 cites W1576608537 @default.
• W2604854931 cites W1845450207 @default.
• W2604854931 cites W1965041156 @default.
• W2604854931 cites W1965130745 @default.
• W2604854931 cites W1983764912 @default.
• W2604854931 cites W1984253600 @default.
• W2604854931 cites W1986240011 @default.
• W2604854931 cites W2002198521 @default.
• W2604854931 cites W2008406050 @default.
• W2604854931 cites W2010708756 @default.
• W2604854931 cites W2028017703 @default.
• W2604854931 cites W2028368506 @default.
• W2604854931 cites W2029203960 @default.
• W2604854931 cites W2031975120 @default.
• W2604854931 cites W2049000251 @default.
• W2604854931 cites W2050868766 @default.
• W2604854931 cites W2057876584 @default.
• W2604854931 cites W2068504803 @default.
• W2604854931 cites W2082783398 @default.
• W2604854931 cites W2096979751 @default.
• W2604854931 cites W2101420246 @default.
• W2604854931 cites W2102155201 @default.
• W2604854931 cites W2104082830 @default.
• W2604854931 cites W2108935165 @default.
• W2604854931 cites W2111504178 @default.
• W2604854931 cites W2131586145 @default.
• W2604854931 cites W2136049487 @default.
• W2604854931 cites W2144016326 @default.
• W2604854931 cites W2149371927 @default.
• W2604854931 cites W2156790441 @default.
• W2604854931 cites W2160661466 @default.
• W2604854931 cites W2172047118 @default.
• W2604854931 cites W2292051166 @default.
• W2604854931 cites W2303508854 @default.
• W2604854931 cites W4294183732 @default.
• W2604854931 doi "https://doi.org/10.1016/j.kint.2017.01.031" @default.
• W2604854931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28396117" @default.
• W2604854931 hasPublicationYear "2017" @default.
• W2604854931 type Work @default.
• W2604854931 sameAs 2604854931 @default.
• W2604854931 citedByCount "52" @default.
• W2604854931 countsByYear W26048549312017 @default.
• W2604854931 countsByYear W26048549312018 @default.
• W2604854931 countsByYear W26048549312019 @default.
• W2604854931 countsByYear W26048549312020 @default.
• W2604854931 countsByYear W26048549312021 @default.
• W2604854931 countsByYear W26048549312022 @default.
• W2604854931 countsByYear W26048549312023 @default.
• W2604854931 crossrefType "journal-article" @default.
• W2604854931 hasAuthorship W2604854931A5010110196 @default.
• W2604854931 hasAuthorship W2604854931A5023097709 @default.
• W2604854931 hasAuthorship W2604854931A5047283512 @default.
• W2604854931 hasAuthorship W2604854931A5051447440 @default.
• W2604854931 hasAuthorship W2604854931A5057361104 @default.
• W2604854931 hasAuthorship W2604854931A5058535138 @default.
• W2604854931 hasAuthorship W2604854931A5064838894 @default.
• W2604854931 hasAuthorship W2604854931A5079834009 @default.
• W2604854931 hasAuthorship W2604854931A5080009275 @default.
• W2604854931 hasBestOaLocation W26048549311 @default.
• W2604854931 hasConcept C126322002 @default.
• W2604854931 hasConcept C134018914 @default.
• W2604854931 hasConcept C2776914184 @default.
• W2604854931 hasConcept C2780114680 @default.
• W2604854931 hasConcept C2780721119 @default.
• W2604854931 hasConcept C541997718 @default.
• W2604854931 hasConcept C71924100 @default.
• W2604854931 hasConcept C98274493 @default.
• W2604854931 hasConceptScore W2604854931C126322002 @default.
• W2604854931 hasConceptScore W2604854931C134018914 @default.
• W2604854931 hasConceptScore W2604854931C2776914184 @default.
• W2604854931 hasConceptScore W2604854931C2780114680 @default.
• W2604854931 hasConceptScore W2604854931C2780721119 @default.
• W2604854931 hasConceptScore W2604854931C541997718 @default.
• W2604854931 hasConceptScore W2604854931C71924100 @default.
• W2604854931 hasConceptScore W2604854931C98274493 @default.
• W2604854931 hasIssue "2" @default.
• W2604854931 hasLocation W26048549311 @default.
• W2604854931 hasLocation W26048549312 @default.
• W2604854931 hasOpenAccess W2604854931 @default.
• W2604854931 hasPrimaryLocation W26048549311 @default.
• W2604854931 hasRelatedWork W1965865258 @default.
• W2604854931 hasRelatedWork W2008327820 @default.
• W2604854931 hasRelatedWork W2026964236 @default.
• W2604854931 hasRelatedWork W2089031022 @default.

• next