Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604920404> ?p ?o ?g. }
- W2604920404 endingPage "187" @default.
- W2604920404 startingPage "175" @default.
- W2604920404 abstract "Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we find that early increase in cytosolic calcium in TNF-induced necroptosis is mediated by treatment with a Smac mimetic via the TNF/RIP1/TAK1 survival pathway. This does not require the activation of the necrosome and is dispensable for necroptosis. Necroptosis induced by the activation of TLR3/4 pathways does not trigger early calcium flux. We also demonstrate that necroptotic plasma membrane rupture is mediated by osmotic forces and membrane pores around 4 nm in diameter. This late permeabilization step represents a hallmark in necroptosis execution that is cell and treatment independent and requires the RIP1/RIP3/MLKL core. In support of this, treatment with osmoprotectants reduces cell damage in an in vivo necroptosis model of ischemia-reperfusion injury." @default.
- W2604920404 created "2017-04-14" @default.
- W2604920404 creator A5013041037 @default.
- W2604920404 creator A5025930111 @default.
- W2604920404 creator A5041672678 @default.
- W2604920404 creator A5050258687 @default.
- W2604920404 creator A5058221436 @default.
- W2604920404 creator A5069709615 @default.
- W2604920404 creator A5079297250 @default.
- W2604920404 date "2017-04-01" @default.
- W2604920404 modified "2023-10-10" @default.
- W2604920404 title "Necroptosis Execution Is Mediated by Plasma Membrane Nanopores Independent of Calcium" @default.
- W2604920404 cites W1548775239 @default.
- W2604920404 cites W1928433221 @default.
- W2604920404 cites W1969323641 @default.
- W2604920404 cites W1974941717 @default.
- W2604920404 cites W1980952670 @default.
- W2604920404 cites W1986283558 @default.
- W2604920404 cites W1991848083 @default.
- W2604920404 cites W1991997670 @default.
- W2604920404 cites W1993262772 @default.
- W2604920404 cites W1995562471 @default.
- W2604920404 cites W2008258524 @default.
- W2604920404 cites W2021358525 @default.
- W2604920404 cites W2025246349 @default.
- W2604920404 cites W2046031057 @default.
- W2604920404 cites W2048488821 @default.
- W2604920404 cites W2049226548 @default.
- W2604920404 cites W2050753030 @default.
- W2604920404 cites W2052605153 @default.
- W2604920404 cites W2053125535 @default.
- W2604920404 cites W2056912730 @default.
- W2604920404 cites W2062111121 @default.
- W2604920404 cites W2062343439 @default.
- W2604920404 cites W2065036369 @default.
- W2604920404 cites W2077317536 @default.
- W2604920404 cites W2080163983 @default.
- W2604920404 cites W2081053802 @default.
- W2604920404 cites W2085006338 @default.
- W2604920404 cites W2087232320 @default.
- W2604920404 cites W2089275663 @default.
- W2604920404 cites W2091363184 @default.
- W2604920404 cites W2093642319 @default.
- W2604920404 cites W2116609506 @default.
- W2604920404 cites W2120626244 @default.
- W2604920404 cites W2125185693 @default.
- W2604920404 cites W2131387907 @default.
- W2604920404 cites W2132161879 @default.
- W2604920404 cites W2139900059 @default.
- W2604920404 cites W2141738274 @default.
- W2604920404 cites W2141918040 @default.
- W2604920404 cites W2149998180 @default.
- W2604920404 cites W2259902722 @default.
- W2604920404 cites W2261153787 @default.
- W2604920404 cites W2278588602 @default.
- W2604920404 cites W2317708108 @default.
- W2604920404 cites W2319054200 @default.
- W2604920404 cites W2319662587 @default.
- W2604920404 cites W2323329832 @default.
- W2604920404 cites W2341301230 @default.
- W2604920404 cites W2462773201 @default.
- W2604920404 cites W2467178923 @default.
- W2604920404 cites W2509895654 @default.
- W2604920404 cites W2513323738 @default.
- W2604920404 cites W2517997111 @default.
- W2604920404 cites W2558370604 @default.
- W2604920404 doi "https://doi.org/10.1016/j.celrep.2017.03.024" @default.
- W2604920404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5465952" @default.
- W2604920404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28380356" @default.
- W2604920404 hasPublicationYear "2017" @default.
- W2604920404 type Work @default.
- W2604920404 sameAs 2604920404 @default.
- W2604920404 citedByCount "96" @default.
- W2604920404 countsByYear W26049204042017 @default.
- W2604920404 countsByYear W26049204042018 @default.
- W2604920404 countsByYear W26049204042019 @default.
- W2604920404 countsByYear W26049204042020 @default.
- W2604920404 countsByYear W26049204042021 @default.
- W2604920404 countsByYear W26049204042022 @default.
- W2604920404 countsByYear W26049204042023 @default.
- W2604920404 crossrefType "journal-article" @default.
- W2604920404 hasAuthorship W2604920404A5013041037 @default.
- W2604920404 hasAuthorship W2604920404A5025930111 @default.
- W2604920404 hasAuthorship W2604920404A5041672678 @default.
- W2604920404 hasAuthorship W2604920404A5050258687 @default.
- W2604920404 hasAuthorship W2604920404A5058221436 @default.
- W2604920404 hasAuthorship W2604920404A5069709615 @default.
- W2604920404 hasAuthorship W2604920404A5079297250 @default.
- W2604920404 hasBestOaLocation W26049204041 @default.
- W2604920404 hasConcept C12554922 @default.
- W2604920404 hasConcept C136449434 @default.
- W2604920404 hasConcept C170493617 @default.
- W2604920404 hasConcept C181199279 @default.
- W2604920404 hasConcept C185592680 @default.
- W2604920404 hasConcept C190283241 @default.
- W2604920404 hasConcept C201571599 @default.
- W2604920404 hasConcept C2776709828 @default.
- W2604920404 hasConcept C2778420691 @default.