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- W2604920986 abstract "TiO2 nanoparticles (NPs) are well-known nanomaterials (NMs), widely used in cosmetics, solar cells, photo-catalysts and additives. Anatase and rutile are the two main crystalline phases of TiO2 NPs and have distinct electrical and optical properties. However, their relative toxicity to organisms is a current topic of debate. In this study, we synthesize both anatase NPs (TiO2-A) and rutile NPs (TiO2-R) with similar particle sizes (20–40 nm), surface areas (51–52 m2/g) and Zeta potentials (−13.4 to −13.7 mV), and investigate their toxicity to macrophages. Contrary to previous findings, TiO2-A show a lower percentage cell deaths compared to TiO2-R (10% vs 20% at 50 mg/L), indicating a lower toxicity compared to TiO2-R. The macrophages treated with TiO2-A and TiO2-R have similar levels of reactive oxygen species (ROS) and the autophagy marker LC3, implying that our observed difference in toxicity is not attributed to oxidative damage and autophagy. Interestingly, TiO2-A cause less severe necrosis and lysosomal membrane permeabilization (LMP), but more severe mitochondrial dysfunction. Adsorption assays further reveal that TiO2-A and TiO2-R have a higher affinity to proteins and phospholipids, respectively. This study demonstrates an important role of crystal phase-related surface affinity to different biomolecules in nanotoxicity." @default.
- W2604920986 created "2017-04-14" @default.
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- W2604920986 date "2017-08-01" @default.
- W2604920986 modified "2023-10-15" @default.
- W2604920986 title "Different toxicity of anatase and rutile TiO 2 nanoparticles on macrophages: Involvement of difference in affinity to proteins and phospholipids" @default.
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- W2604920986 doi "https://doi.org/10.1016/j.jhazmat.2017.04.026" @default.
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