FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2604929792> ?p ?o ?g. }

• W2604929792 endingPage "1161" @default.
• W2604929792 startingPage "1151" @default.
• W2604929792 abstract "The periaqueductal gray matter (PAG) is rich in mu and kappa opioid receptors, and this system is involved in thermoregulation, analgesia, and defensive behaviors. No study approached the involvement of the PAG opioids in body temperature (Tb) regulation during psychological stress such as restraint. Because activation of mu and kappa receptors increases and reduces Tb, respectively, we tested the hypothesis that they exert excitatory and inhibitory modulation, respectively, of the restraint-induced fever in rats. To this end, Tb, heat loss index (HLI, inference for peripheral vasoconstriction/vasodilation), and oxygen consumption (inference for thermogenesis) were monitored in unanesthetized rats, restrained or unrestrained, before and after intra-PAG microinjection of the selective mu opioid receptor antagonist (D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 cyclic, CTAP; 1 and 10 μg/100 nL) or the selective kappa opioid receptor antagonist (nor-binaltorphimine dihydrochloride, nor-BNI; 1 and 4 μg/100 nL) or saline (100 nL). CTAP and nor-BNI did not change the Tb or HLI of euthermic animals. During restraint, Tb increased (1.0 ± 0.1 °C) in all groups; however, this effect was lower in those animals treated with CTAP and higher in animals treated with nor-BNI. The HLI decreased during restraint and increased after animals were released, but this response was not affected by any treatment. Restraint stress increased oxygen consumption (35.9 ± 3.9% elevation), but this response was diminished by CTAP and overstimulated by nor-BNI. Confirming our hypothesis, the results indicate that the mu and kappa opioid receptors in the PAG of rats play a pyrogenic and antipyretic role, respectively, during fever induced by restraint by affecting the thermogenic but not the heat conservation effector." @default.
• W2604929792 created "2017-04-14" @default.
• W2604929792 creator A5000194947 @default.
• W2604929792 creator A5010985375 @default.
• W2604929792 creator A5029649532 @default.
• W2604929792 creator A5062444897 @default.
• W2604929792 date "2017-04-04" @default.
• W2604929792 modified "2023-10-01" @default.
• W2604929792 title "Mu and kappa opioid receptors of the periaqueductal gray stimulate and inhibit thermogenesis, respectively, during psychological stress in rats" @default.
• W2604929792 cites W1032835256 @default.
• W2604929792 cites W1513763202 @default.
• W2604929792 cites W1514119082 @default.
• W2604929792 cites W1523806406 @default.
• W2604929792 cites W1576130054 @default.
• W2604929792 cites W1626809853 @default.
• W2604929792 cites W1786467339 @default.
• W2604929792 cites W1789439462 @default.
• W2604929792 cites W1851987690 @default.
• W2604929792 cites W1922460860 @default.
• W2604929792 cites W1951056124 @default.
• W2604929792 cites W1961836052 @default.
• W2604929792 cites W1973450964 @default.
• W2604929792 cites W1978250701 @default.
• W2604929792 cites W1986680981 @default.
• W2604929792 cites W1988101558 @default.
• W2604929792 cites W1990876574 @default.
• W2604929792 cites W1992238581 @default.
• W2604929792 cites W1992812745 @default.
• W2604929792 cites W1994564077 @default.
• W2604929792 cites W1995301708 @default.
• W2604929792 cites W1996844761 @default.
• W2604929792 cites W1997541372 @default.
• W2604929792 cites W2001266985 @default.
• W2604929792 cites W2004540171 @default.
• W2604929792 cites W2005769782 @default.
• W2604929792 cites W2006791697 @default.
• W2604929792 cites W2007691475 @default.
• W2604929792 cites W2010327147 @default.
• W2604929792 cites W2012034220 @default.
• W2604929792 cites W2012952384 @default.
• W2604929792 cites W2015827321 @default.
• W2604929792 cites W2016782889 @default.
• W2604929792 cites W2024578445 @default.
• W2604929792 cites W2027712680 @default.
• W2604929792 cites W2029569556 @default.
• W2604929792 cites W2029914471 @default.
• W2604929792 cites W2037043198 @default.
• W2604929792 cites W2038349104 @default.
• W2604929792 cites W2038623076 @default.
• W2604929792 cites W2041465976 @default.
• W2604929792 cites W2044879864 @default.
• W2604929792 cites W2046562881 @default.
• W2604929792 cites W2046736242 @default.
• W2604929792 cites W2054577906 @default.
• W2604929792 cites W2055630157 @default.
• W2604929792 cites W2056498971 @default.
• W2604929792 cites W2061277532 @default.
• W2604929792 cites W2061729811 @default.
• W2604929792 cites W2062346120 @default.
• W2604929792 cites W2062745050 @default.
• W2604929792 cites W2063512888 @default.
• W2604929792 cites W2065665591 @default.
• W2604929792 cites W2068904721 @default.
• W2604929792 cites W2069846407 @default.
• W2604929792 cites W2070125182 @default.
• W2604929792 cites W2078131304 @default.
• W2604929792 cites W2080369665 @default.
• W2604929792 cites W2081795763 @default.
• W2604929792 cites W2083519314 @default.
• W2604929792 cites W2084646626 @default.
• W2604929792 cites W2086855996 @default.
• W2604929792 cites W2087870123 @default.
• W2604929792 cites W2089600276 @default.
• W2604929792 cites W2090272685 @default.
• W2604929792 cites W2094619192 @default.
• W2604929792 cites W2096263149 @default.
• W2604929792 cites W2096659617 @default.
• W2604929792 cites W2097382546 @default.
• W2604929792 cites W2105163313 @default.
• W2604929792 cites W2132164381 @default.
• W2604929792 cites W2140104467 @default.
• W2604929792 cites W2140442141 @default.
• W2604929792 cites W2147262596 @default.
• W2604929792 cites W2147780562 @default.
• W2604929792 cites W2151665669 @default.
• W2604929792 cites W2156243671 @default.
• W2604929792 cites W2158329247 @default.
• W2604929792 cites W2158553737 @default.
• W2604929792 cites W2164819541 @default.
• W2604929792 cites W2168603460 @default.
• W2604929792 cites W2172323892 @default.
• W2604929792 cites W2180468653 @default.
• W2604929792 cites W2193003531 @default.
• W2604929792 cites W2235649263 @default.
• W2604929792 cites W2264466740 @default.
• W2604929792 cites W2278200737 @default.
• W2604929792 cites W2326255967 @default.
• W2604929792 cites W2334905704 @default.

• next