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• W2604955466 abstract "Gold nanoparticles (GNPs) have antioxidant and anti-inflammatory effects. However, toxicity is still a concern; therefore, it is critical to study both the therapeutic and toxic properties of GNPs. In this study, we evaluated the effects of the intraperitoneal administration of GNPs (20 nm, at a concentration of 2.5 mg/L for 21 days) every 24 or 48 h on oxidative stress, antioxidant status, and electron chain transport (ETC) in the brain. Liver histology and blood marker analyses were conducted to establish a time routine of GNP administration. The concentrations of GNP in the brain and liver were similar. Hepatic and serum levels of cholesterol, triglycerides, and transaminases were not altered after the administration of GNP every 24 or 48 h. The superoxide and nitric oxide levels were unchanged after administration of GNP. Dichlorodihydrofluorescein (DCFH) levels decreased after the administration of GNP every 48 h compared with that in the saline group. Sulfhydryl and carbonyl levels, as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and glutathione (GSH) activities were not altered in the brain after administration of GNP in the two time periods studied. The GNP 48 h group showed increased brain ETC activity. Compared to that in the saline group, the GNP 24 h group showed marked parenchyma changes with cell necrosis and leukocyte infiltration. We therefore suggest that a concentration of 2.5 mg/L of GNP administered every 48 h has potential therapeutic benefits without toxicity." @default.
• W2604955466 created "2017-04-14" @default.
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• W2604955466 date "2017-08-01" @default.
• W2604955466 modified "2023-09-29" @default.
• W2604955466 title "Safety protocol for the gold nanoparticles administration in rats" @default.
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• W2604955466 doi "https://doi.org/10.1016/j.msec.2017.04.027" @default.
• W2604955466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28531990" @default.
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