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• W2605011736 abstract "You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History II1 Apr 2017MP14-12 PATIENT-REPORTED URINARY BOTHER – WHAT IS REALLY BOTHERING PROSTATE CANCER PATIENTS? Lin Yang, Adam Kibel, Graham Colditz, Ratna Pakpahan, Kellie Imm, Sonya Izadi, Robert Grubb, Kathleen Wolin, and Siobhan Sutcliffe Lin YangLin Yang More articles by this author , Adam KibelAdam Kibel More articles by this author , Graham ColditzGraham Colditz More articles by this author , Ratna PakpahanRatna Pakpahan More articles by this author , Kellie ImmKellie Imm More articles by this author , Sonya IzadiSonya Izadi More articles by this author , Robert GrubbRobert Grubb More articles by this author , Kathleen WolinKathleen Wolin More articles by this author , and Siobhan SutcliffeSiobhan Sutcliffe More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.476AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Although research on prostate cancer survivorship points to the importance of shifting our perspective from patient function to patient satisfaction measures, few studies have focused on urinary symptom bother (UB) or its relation to urinary function (UF) in prostate cancer patients undergoing radical prostatectomy (RP). This question is important because it may inform possible non-functional mechanisms for UB, and thus modifiable targets to improve patient satisfaction following RP. Therefore, we examined the degree of concordance between patient-reported UF and UB in the Prostatectomy, Incontinence and Erectile function (PIE) study. METHODS PIE participants were recruited from 2011 to 2014 at Washington University School of Medicine and Brigham & Women's Hospital. Patient-reported outcome measures (PROMs), including UF and UB, were measured by the Expanded Prostate Cancer Index Composite (EPIC-50) pre and 5 weeks post RP in 384 men. Spearman's rank correlation coefficients were used to describe the concordance between UF and UB. RESULTS We observed overall agreement between UF and UB (r=0.51, see Table 1). However, two distinct groups with differing function and bother were observed: 1) men with high function and bother pre-RP (17.7%), and 2) men with low function and bother 5 weeks post-RP (27.9%). The group with high baseline urinary function and high bother (17.7%) was largely explained by differences in the components assessed by the UF and UB scales. Both of these scales measure incontinence, but the UB scale additionally measures irritative/obstructive symptoms, such as seen in men with benign prostatic hyperplasia (BPH). Splitting the UB scale into two (one for incontinence and one for irritative/obstructive symptoms), or limiting the analyses to men with non-enlarged prostates who are less likely to have BPH, resulted in considerably better agreement between UF and UB (r=0.63 for non-enlarged vs r=0.48 for enlarged prostate size). CONCLUSIONS In a pre-surgical cohort of prostate cancer patients, co-existing BPH-associated irritative/obstructive symptoms may distort measurement of UB using EPIC. In natural history studies that compare pre-to post-RP outcomes, splitting incontinence-related UB and irritative/obstructive symptom-related UB may improve the utility of this PROM. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e166 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Lin Yang More articles by this author Adam Kibel More articles by this author Graham Colditz More articles by this author Ratna Pakpahan More articles by this author Kellie Imm More articles by this author Sonya Izadi More articles by this author Robert Grubb More articles by this author Kathleen Wolin More articles by this author Siobhan Sutcliffe More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2605011736 title "MP14-12 PATIENT-REPORTED URINARY BOTHER – WHAT IS REALLY BOTHERING PROSTATE CANCER PATIENTS?" @default.
• W2605011736 doi "https://doi.org/10.1016/j.juro.2017.02.476" @default.
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