FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605018081> ?p ?o ?g. }

• W2605018081 endingPage "68" @default.
• W2605018081 startingPage "54" @default.
• W2605018081 abstract "Hypericin is an endoplasmic reticulum (ER)-located photosensitizer, which causes oxidative damage to ER during photodynamic therapy (PDT). Hypericin-mediated PDT (HY-PDT) has been confirmed to enhance chemo-sensitivity of oxaliplatin (L-OHP) in colon cancer cells. The present study reveals that autophagy plays a key role in chemosensitization during HY-PDT. We proved pro-death autophagy was required for sensitization and HY-PDT/L-OHP antitumor synergism. High dosage of HY-PDT induced autophagic cell death; while low dose of HY-PDT predominantly triggered protective autophagy and promoted cell proliferation. Low dose of HY-PDT reduced the cytotoxicity of L-OHP in oxaliplatin-resistant colon cancer cells. Different level of autophagy therefore contributed to the opposite effect of HY-PDT on cell fate and chemo-sensitivity. Furthermore, we revealed the role of CHOP as a regulator connecting pro-survival and pro-death autophagy under ER damage. High dose of HY-PDT induced massive ROS generation and severe ER stress, which then led to induction of CHOP. CHOP thereby activated CHOP/TRIB3/Akt/mTOR cascade and triggered autophagic cell death. Additionally, when apoptotic pathway was blocked, cells treated with high dose of HY-PDT preferentially underwent death through autophagic pathway. On the other hand, suppression of autophagy made cells more vulnerable to apoptosis under low dose of HY-PDT. These results provided new evidences for the clinical application of ER-targeting PDT in modifying chemosensitivity of colorectal cancer therapy." @default.
• W2605018081 created "2017-04-14" @default.
• W2605018081 creator A5001215942 @default.
• W2605018081 creator A5019160217 @default.
• W2605018081 creator A5026613127 @default.
• W2605018081 creator A5028510174 @default.
• W2605018081 creator A5029335956 @default.
• W2605018081 creator A5034021618 @default.
• W2605018081 creator A5066110563 @default.
• W2605018081 creator A5067130416 @default.
• W2605018081 creator A5074800265 @default.
• W2605018081 date "2017-06-01" @default.
• W2605018081 modified "2023-10-16" @default.
• W2605018081 title "Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy" @default.
• W2605018081 cites W1481314844 @default.
• W2605018081 cites W1528462551 @default.
• W2605018081 cites W1533118132 @default.
• W2605018081 cites W1963527340 @default.
• W2605018081 cites W1973932751 @default.
• W2605018081 cites W1975365466 @default.
• W2605018081 cites W1976531450 @default.
• W2605018081 cites W1976941064 @default.
• W2605018081 cites W1986683769 @default.
• W2605018081 cites W1988404809 @default.
• W2605018081 cites W1993908556 @default.
• W2605018081 cites W1999677324 @default.
• W2605018081 cites W2003368618 @default.
• W2605018081 cites W2022724942 @default.
• W2605018081 cites W2026660662 @default.
• W2605018081 cites W2029176887 @default.
• W2605018081 cites W2032324982 @default.
• W2605018081 cites W2033771763 @default.
• W2605018081 cites W2036417968 @default.
• W2605018081 cites W2040120980 @default.
• W2605018081 cites W2041033535 @default.
• W2605018081 cites W2041595418 @default.
• W2605018081 cites W2044630250 @default.
• W2605018081 cites W2048098925 @default.
• W2605018081 cites W2049141998 @default.
• W2605018081 cites W2052792097 @default.
• W2605018081 cites W2058388635 @default.
• W2605018081 cites W2062119413 @default.
• W2605018081 cites W2065126270 @default.
• W2605018081 cites W2069924169 @default.
• W2605018081 cites W2074662347 @default.
• W2605018081 cites W2076745136 @default.
• W2605018081 cites W2079351077 @default.
• W2605018081 cites W2080100430 @default.
• W2605018081 cites W2083502773 @default.
• W2605018081 cites W2088155937 @default.
• W2605018081 cites W2089039955 @default.
• W2605018081 cites W2092820966 @default.
• W2605018081 cites W2101399736 @default.
• W2605018081 cites W2106409322 @default.
• W2605018081 cites W2112378033 @default.
• W2605018081 cites W2126967375 @default.
• W2605018081 cites W2127431494 @default.
• W2605018081 cites W2133578495 @default.
• W2605018081 cites W2134197723 @default.
• W2605018081 cites W2142859236 @default.
• W2605018081 cites W2144002661 @default.
• W2605018081 cites W2153680912 @default.
• W2605018081 cites W2154125015 @default.
• W2605018081 cites W2156118142 @default.
• W2605018081 cites W2156320420 @default.
• W2605018081 cites W2165138487 @default.
• W2605018081 cites W2167454223 @default.
• W2605018081 cites W2168453644 @default.
• W2605018081 cites W2170801813 @default.
• W2605018081 cites W2193698751 @default.
• W2605018081 cites W2314587484 @default.
• W2605018081 cites W97697689 @default.
• W2605018081 doi "https://doi.org/10.1016/j.biocel.2017.04.001" @default.
• W2605018081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28392376" @default.
• W2605018081 hasPublicationYear "2017" @default.
• W2605018081 type Work @default.
• W2605018081 sameAs 2605018081 @default.
• W2605018081 citedByCount "40" @default.
• W2605018081 countsByYear W26050180812017 @default.
• W2605018081 countsByYear W26050180812018 @default.
• W2605018081 countsByYear W26050180812019 @default.
• W2605018081 countsByYear W26050180812020 @default.
• W2605018081 countsByYear W26050180812021 @default.
• W2605018081 countsByYear W26050180812022 @default.
• W2605018081 countsByYear W26050180812023 @default.
• W2605018081 crossrefType "journal-article" @default.
• W2605018081 hasAuthorship W2605018081A5001215942 @default.
• W2605018081 hasAuthorship W2605018081A5019160217 @default.
• W2605018081 hasAuthorship W2605018081A5026613127 @default.
• W2605018081 hasAuthorship W2605018081A5028510174 @default.
• W2605018081 hasAuthorship W2605018081A5029335956 @default.
• W2605018081 hasAuthorship W2605018081A5034021618 @default.
• W2605018081 hasAuthorship W2605018081A5066110563 @default.
• W2605018081 hasAuthorship W2605018081A5067130416 @default.
• W2605018081 hasAuthorship W2605018081A5074800265 @default.
• W2605018081 hasConcept C121608353 @default.
• W2605018081 hasConcept C126322002 @default.
• W2605018081 hasConcept C139447449 @default.

• next