Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605032851> ?p ?o ?g. }
- W2605032851 endingPage "638" @default.
- W2605032851 startingPage "626" @default.
- W2605032851 abstract "Background Cortical spreading depression (CSD) related diseases such as migraine, cerebrovascular diseases, and epilepsy have been associated with reactive astrocytosis, yet the mechanisms of these tissue changes remain unclear. CSD-induced inflammatory response has been proposed to play a role in some neurological disorders and thus may also contribute to reactive astrocytosis. Methods Using ex vivo brain slices and in vitro astrocytic cultures, we aimed to characterize CSD related changes in astrocytes and markers of inflammation by immunocyto- and immunohistochemistry. CSD was induced by application of KCl (3 mol/l) on neocortical tissues. The application of KCl was repeated weekly over the course of four weeks. Results CSD induced an increase in the mean number and volume of astrocytes in rat brain tissue when compared to controls, whereas no changes in neuronal numbers and volumes were seen. These cell-type specific changes, suggestive of reactive astrocytosis, were paralleled by an increased expression of protein markers indicative of astrocytes and neuroinflammation in ex vivo brain slices of animals undergoing CSD when compared to sham-treated controls. Cultured astrocytes showed an increased expression of the immune modulatory enzyme indoleamine 2,3-dioxygenase and an elevated expression of the pro-inflammatory markers, IL-6, IL-1β, and TNFα in addition to increased levels of toll like receptors (TLR3 and TLR4) and astrocytic markers after induction of CSD. Conclusion These findings indicate that CSD related reactive astrocytosis is linked to an upregulation of inflammatory markers. Targeting inflammation with already approved and available immunomodulatory treatments may thus represent a strategy to combat or ameliorate CSD-related disease." @default.
- W2605032851 created "2017-04-14" @default.
- W2605032851 creator A5021999843 @default.
- W2605032851 creator A5028117686 @default.
- W2605032851 creator A5034872348 @default.
- W2605032851 creator A5039183758 @default.
- W2605032851 creator A5065525659 @default.
- W2605032851 creator A5067090146 @default.
- W2605032851 creator A5079818564 @default.
- W2605032851 creator A5084918739 @default.
- W2605032851 date "2017-04-03" @default.
- W2605032851 modified "2023-09-29" @default.
- W2605032851 title "Astrocyte-mediated inflammation in cortical spreading depression" @default.
- W2605032851 cites W1004096992 @default.
- W2605032851 cites W1503511302 @default.
- W2605032851 cites W1567052617 @default.
- W2605032851 cites W1627504329 @default.
- W2605032851 cites W1972650471 @default.
- W2605032851 cites W1978836458 @default.
- W2605032851 cites W1979009614 @default.
- W2605032851 cites W1988886033 @default.
- W2605032851 cites W1989255295 @default.
- W2605032851 cites W1990010538 @default.
- W2605032851 cites W1994653696 @default.
- W2605032851 cites W2003509571 @default.
- W2605032851 cites W2018101299 @default.
- W2605032851 cites W2024660851 @default.
- W2605032851 cites W2035207421 @default.
- W2605032851 cites W2039998628 @default.
- W2605032851 cites W2044856436 @default.
- W2605032851 cites W2045450157 @default.
- W2605032851 cites W2047585900 @default.
- W2605032851 cites W2055448024 @default.
- W2605032851 cites W2063155936 @default.
- W2605032851 cites W2066384268 @default.
- W2605032851 cites W2066875663 @default.
- W2605032851 cites W2071695496 @default.
- W2605032851 cites W2081689918 @default.
- W2605032851 cites W2083695557 @default.
- W2605032851 cites W2088926350 @default.
- W2605032851 cites W2089879126 @default.
- W2605032851 cites W2093111103 @default.
- W2605032851 cites W2096078423 @default.
- W2605032851 cites W2107293768 @default.
- W2605032851 cites W2110399898 @default.
- W2605032851 cites W2111464898 @default.
- W2605032851 cites W2115237675 @default.
- W2605032851 cites W2144759791 @default.
- W2605032851 cites W2155943478 @default.
- W2605032851 cites W2168626405 @default.
- W2605032851 cites W2217432868 @default.
- W2605032851 cites W2217637761 @default.
- W2605032851 cites W2265544237 @default.
- W2605032851 cites W2317687723 @default.
- W2605032851 cites W2338299306 @default.
- W2605032851 cites W2350266534 @default.
- W2605032851 cites W2413834269 @default.
- W2605032851 cites W4293247451 @default.
- W2605032851 doi "https://doi.org/10.1177/0333102417702132" @default.
- W2605032851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28372497" @default.
- W2605032851 hasPublicationYear "2017" @default.
- W2605032851 type Work @default.
- W2605032851 sameAs 2605032851 @default.
- W2605032851 citedByCount "54" @default.
- W2605032851 countsByYear W26050328512017 @default.
- W2605032851 countsByYear W26050328512018 @default.
- W2605032851 countsByYear W26050328512019 @default.
- W2605032851 countsByYear W26050328512020 @default.
- W2605032851 countsByYear W26050328512021 @default.
- W2605032851 countsByYear W26050328512022 @default.
- W2605032851 countsByYear W26050328512023 @default.
- W2605032851 crossrefType "journal-article" @default.
- W2605032851 hasAuthorship W2605032851A5021999843 @default.
- W2605032851 hasAuthorship W2605032851A5028117686 @default.
- W2605032851 hasAuthorship W2605032851A5034872348 @default.
- W2605032851 hasAuthorship W2605032851A5039183758 @default.
- W2605032851 hasAuthorship W2605032851A5065525659 @default.
- W2605032851 hasAuthorship W2605032851A5067090146 @default.
- W2605032851 hasAuthorship W2605032851A5079818564 @default.
- W2605032851 hasAuthorship W2605032851A5084918739 @default.
- W2605032851 hasConcept C134018914 @default.
- W2605032851 hasConcept C136834591 @default.
- W2605032851 hasConcept C142724271 @default.
- W2605032851 hasConcept C150903083 @default.
- W2605032851 hasConcept C169760540 @default.
- W2605032851 hasConcept C203014093 @default.
- W2605032851 hasConcept C204232928 @default.
- W2605032851 hasConcept C207001950 @default.
- W2605032851 hasConcept C26291073 @default.
- W2605032851 hasConcept C2776070231 @default.
- W2605032851 hasConcept C2776914184 @default.
- W2605032851 hasConcept C2777542381 @default.
- W2605032851 hasConcept C2777682930 @default.
- W2605032851 hasConcept C2779830541 @default.
- W2605032851 hasConcept C28328180 @default.
- W2605032851 hasConcept C2908656565 @default.
- W2605032851 hasConcept C48261664 @default.
- W2605032851 hasConcept C529278444 @default.