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• W2605087191 abstract "You have accessJournal of UrologyBladder Cancer: Invasive IV1 Apr 2017MP54-15 PURE BUT NOT MIXED HISTOLOGICAL VARIANTS ARE ASSOCIATED WITH POOR SURVIVAL AT RADICAL CYSTECTOMY IN BLADDER CANCER PATIENTS Marco Moschini, Renzo Colombo, Giorgio Gandaglia, Ettore Di Trapani, Giusy Burgio, Rocco Damiano, Agostino Mattei, Shahrokh Shariat, Andrea Salonia, Alberto Briganti, Francesco Montorsi, and Andrea Gallina Marco MoschiniMarco Moschini More articles by this author , Renzo ColomboRenzo Colombo More articles by this author , Giorgio GandagliaGiorgio Gandaglia More articles by this author , Ettore Di TrapaniEttore Di Trapani More articles by this author , Giusy BurgioGiusy Burgio More articles by this author , Rocco DamianoRocco Damiano More articles by this author , Agostino MatteiAgostino Mattei More articles by this author , Shahrokh ShariatShahrokh Shariat More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea GallinaAndrea Gallina More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1687AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the impact of pure and mixed histological variant versus pure urothelial carcinoma in nonmetastatic bladder cancer (BCa) patients treated with radical cystectomy (RC) in a single institution center. METHODS We evaluated data from 1,067 patients treated at a single institution with RC and pelvic lymph node dissection between 1990 and 2013 at a single institution tertiary care referral center. All specimen were evaluated by dedicated uropathologists. Univariable and multivariable Cox regression analyses tested the impact of the presence of pure and mixed histologic variants vs. pure urothelial and recurrence, CSM (cancer specific mortality) and OM (overall mortality) after accounting for all available confounders. RESULTS In total, 201 (19%) and 137 (13%) patients were found with mixed and pure variant at RC, respectively. Mixed variant were preponderant in sarcomatoid, lymphoepitelial, squamous and glandular variants, on the other hand, small cell and micropapillary variants were found mostly as pure variants. With a median follow up of 6.5 years, patients who harbored pure variant were found at multivariablean alyses with lower survival outcomes when compared with pure urothelial carcinoma (all p<0.01). Conversely no differences were found between mixed variant vs. pure urothelial at multivariable Cox regression analyses predicting recurrence, CSM and OM (all p>0.1). CONCLUSIONS Presence of histologic variants at RC is a common finding accounting for approximately 30% of specimens. In this setting, the presence of a pure variant but not the presence of mixed variant with urothelial carcinoma is related to a detrimental effect on survival outcomes after RC. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e727-e728 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Marco Moschini More articles by this author Renzo Colombo More articles by this author Giorgio Gandaglia More articles by this author Ettore Di Trapani More articles by this author Giusy Burgio More articles by this author Rocco Damiano More articles by this author Agostino Mattei More articles by this author Shahrokh Shariat More articles by this author Andrea Salonia More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Andrea Gallina More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
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• W2605087191 title "MP54-15 PURE BUT NOT MIXED HISTOLOGICAL VARIANTS ARE ASSOCIATED WITH POOR SURVIVAL AT RADICAL CYSTECTOMY IN BLADDER CANCER PATIENTS" @default.
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