FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605114328> ?p ?o ?g. }

• W2605114328 abstract "You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I1 Apr 2017PD12-10 KIDNEY INJURY MOLECULE-1 AS A POTENTIAL URINARY BIOMARKER OF HYDRONEPROSIS MAY NOT BE AFFECTED BY INFLAMMATORY CAUSES IN THE URINARY TRACT Daniel Olvera-Posada, Stephen Pautler, Alp Sener, John Denstedt, and Hassan Razvi Daniel Olvera-PosadaDaniel Olvera-Posada More articles by this author , Stephen PautlerStephen Pautler More articles by this author , Alp SenerAlp Sener More articles by this author , John DenstedtJohn Denstedt More articles by this author , and Hassan RazviHassan Razvi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.685AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Newly discovered biomarkers have been used to assess renal function in several clinical situations, and diverse studies have suggested a relationship between urinary tract obstruction and increased levels of these biomarkers. It has been postulated that some inflammatory conditions may affect the expression of these markers precluding its use in our population. We planned to evaluate the urinary levels of Kidney Injury Molecule-1 in a set of urological patients to determine which factors may be associated with its expression. METHODS From a prospective observational cohort study, we included patients with hydronephrosis caused by renal stone disease or ureteric stricture, and patients with non-obstructive nephrolithiasis. Demographical, clinical and radiological characteristics were evaluated before and after surgical treatment. Urinary normalized KIM-1 concentration was measured using ELISA analyses in three different occasions, one preoperative and in two postoperative assessments. Non-parametric tests were used to compare KIM-1 levels during follow-up. The presence of stone disease, double J stent and hydronephrosis were noted and dichotomized. Correlations between biomarkers' levels and clinical or radiological characteristics were assessed using Spearman's correlation coefficient. RESULTS Forty-eight patients and eleven controls were included in the final analysis. First and second postoperative assessment were performed with a median of 17 days (IQR 9.5) and 59 days (IQR 34) after the surgical procedure. Patients with hydronephrosis showed a higher KIM-1 concentration than no-hydro patients and controls (1.19 vs 0.60 ng/mg creatinine, p=0.002). After analyzing KIM-1 expression in hydronephrosis patients exclusively, we found significantly higher levels at baseline, compared to both postoperative evaluations (p<0.001). KIM-1 showed a weak correlation with age, female gender, BMI, Charlson Comorbidity Index and presence of hydronephrosis (p<0.0001). Although, its expression was not correlated with the estimated glomerular filtration rate, leukocyturia, or presence of stone disease. The distribution of KIM-1 levels amongst patients with non-obstructive stone disease did not significantly change despite the surgical management. CONCLUSIONS This exploratory study found that urinary KIM-1 expression could potentially be affected by some patients' baseline characteristics. However, our results corroborate that urinary KIM-1 may be a reliable marker of hydronephrosis. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e269 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Daniel Olvera-Posada More articles by this author Stephen Pautler More articles by this author Alp Sener More articles by this author John Denstedt More articles by this author Hassan Razvi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2605114328 created "2017-04-14" @default.
• W2605114328 creator A5022101797 @default.
• W2605114328 creator A5031381830 @default.
• W2605114328 creator A5053982571 @default.
• W2605114328 creator A5057713377 @default.
• W2605114328 creator A5078207248 @default.
• W2605114328 date "2017-04-01" @default.
• W2605114328 modified "2023-09-25" @default.
• W2605114328 title "PD12-10 KIDNEY INJURY MOLECULE-1 AS A POTENTIAL URINARY BIOMARKER OF HYDRONEPROSIS MAY NOT BE AFFECTED BY INFLAMMATORY CAUSES IN THE URINARY TRACT" @default.
• W2605114328 doi "https://doi.org/10.1016/j.juro.2017.02.685" @default.
• W2605114328 hasPublicationYear "2017" @default.
• W2605114328 type Work @default.
• W2605114328 sameAs 2605114328 @default.
• W2605114328 citedByCount "0" @default.
• W2605114328 crossrefType "journal-article" @default.
• W2605114328 hasAuthorship W2605114328A5022101797 @default.
• W2605114328 hasAuthorship W2605114328A5031381830 @default.
• W2605114328 hasAuthorship W2605114328A5053982571 @default.
• W2605114328 hasAuthorship W2605114328A5057713377 @default.
• W2605114328 hasAuthorship W2605114328A5078207248 @default.
• W2605114328 hasBestOaLocation W26051143281 @default.
• W2605114328 hasConcept C126322002 @default.
• W2605114328 hasConcept C126894567 @default.
• W2605114328 hasConcept C133507102 @default.
• W2605114328 hasConcept C185592680 @default.
• W2605114328 hasConcept C188816634 @default.
• W2605114328 hasConcept C2778653478 @default.
• W2605114328 hasConcept C2779728849 @default.
• W2605114328 hasConcept C2780091579 @default.
• W2605114328 hasConcept C2781040948 @default.
• W2605114328 hasConcept C2781197716 @default.
• W2605114328 hasConcept C2908647359 @default.
• W2605114328 hasConcept C55493867 @default.
• W2605114328 hasConcept C71924100 @default.
• W2605114328 hasConcept C77411442 @default.
• W2605114328 hasConcept C99454951 @default.
• W2605114328 hasConceptScore W2605114328C126322002 @default.
• W2605114328 hasConceptScore W2605114328C126894567 @default.
• W2605114328 hasConceptScore W2605114328C133507102 @default.
• W2605114328 hasConceptScore W2605114328C185592680 @default.
• W2605114328 hasConceptScore W2605114328C188816634 @default.
• W2605114328 hasConceptScore W2605114328C2778653478 @default.
• W2605114328 hasConceptScore W2605114328C2779728849 @default.
• W2605114328 hasConceptScore W2605114328C2780091579 @default.
• W2605114328 hasConceptScore W2605114328C2781040948 @default.
• W2605114328 hasConceptScore W2605114328C2781197716 @default.
• W2605114328 hasConceptScore W2605114328C2908647359 @default.
• W2605114328 hasConceptScore W2605114328C55493867 @default.
• W2605114328 hasConceptScore W2605114328C71924100 @default.
• W2605114328 hasConceptScore W2605114328C77411442 @default.
• W2605114328 hasConceptScore W2605114328C99454951 @default.
• W2605114328 hasIssue "4S" @default.
• W2605114328 hasLocation W26051143281 @default.
• W2605114328 hasOpenAccess W2605114328 @default.
• W2605114328 hasPrimaryLocation W26051143281 @default.
• W2605114328 hasRelatedWork W1978552364 @default.
• W2605114328 hasRelatedWork W2040703516 @default.
• W2605114328 hasRelatedWork W2081141743 @default.
• W2605114328 hasRelatedWork W2152061311 @default.
• W2605114328 hasRelatedWork W2394012089 @default.
• W2605114328 hasRelatedWork W2587758174 @default.
• W2605114328 hasRelatedWork W268548362 @default.
• W2605114328 hasRelatedWork W3090033145 @default.
• W2605114328 hasRelatedWork W3101004943 @default.
• W2605114328 hasRelatedWork W594423002 @default.
• W2605114328 hasVolume "197" @default.
• W2605114328 isParatext "false" @default.
• W2605114328 isRetracted "false" @default.
• W2605114328 magId "2605114328" @default.
• W2605114328 workType "article" @default.