FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605143263> ?p ?o ?g. }

• W2605143263 endingPage "485" @default.
• W2605143263 startingPage "476" @default.
• W2605143263 abstract "Translational research depends on the relevance of animal models and how well they replicate human disease. Here, we investigated plasma levels of three important pro‐inflammatory cytokines (TNFα, IL‐6, and MCP‐1), known to be elevated in human pulmonary arterial hypertension (PAH), and systematically assessed their levels in PAH patients compared to five different rodent models of pulmonary hypertension (PH). A consistent immunoassay platform (Luminex xMAP) and source (Millipore) was used to measure all specimens. PAH patients (n = 29) exhibited significant elevations in all three cytokines (median [IQR] pg/mL; TNFα, 7.0 [4.8–11.7]; IL‐6, 9.2 [3.8–17.2]; MCP‐1, 109 [65–142]) versus healthy participants (n = 20) (median [IQR] pg/mL; TNFα, 3.0 [2.0–3.6]; IL‐6, 1.7 [0.5–7.2]; MCP‐1, 79 [49–93]. In contrast, mice with PH established after three weeks of hypoxia (n = 18) or SU5416 plus hypoxia (n = 20) showed no significant change in their plasma cytokine levels versus controls (n = 16), based on three to four independent experiments per group. Similarly, plasma cytokine levels were not elevated in rats with PH established three weeks after monocrotaline (n = 23), eight weeks after SU5416 alone (n = 10) or six to eight weeks after SU5416 plus hypoxia (n = 21) versus controls (n = 36 rats), based on three to eight independent experiments per group. Positive biologic control specimens from sepsis patients (n = 9), cecal‐ligation and puncture (CLP)‐induced septic mice (n = 6), and lipopolysaccharide‐induced septic rats (n = 4) showed robust elevations in all three cytokines. This study suggests that animal models commonly used for the development of novel diagnostic and therapeutic approaches for PAH may have limited construct validity with respect to markers of systemic immune activation seen in human patients." @default.
• W2605143263 created "2017-04-14" @default.
• W2605143263 creator A5044538468 @default.
• W2605143263 creator A5048505819 @default.
• W2605143263 creator A5069735529 @default.
• W2605143263 creator A5084706902 @default.
• W2605143263 creator A5085718584 @default.
• W2605143263 creator A5089741245 @default.
• W2605143263 creator A5090011367 @default.
• W2605143263 date "2017-04-01" @default.
• W2605143263 modified "2023-09-27" @default.
• W2605143263 title "Lack of elevation in plasma levels of pro‐inflammatory cytokines in common rodent models of pulmonary arterial hypertension: questions of construct validity for human patients" @default.
• W2605143263 cites W1758075256 @default.
• W2605143263 cites W1923732143 @default.
• W2605143263 cites W1967675172 @default.
• W2605143263 cites W1993537235 @default.
• W2605143263 cites W2022893015 @default.
• W2605143263 cites W2026469629 @default.
• W2605143263 cites W2076088701 @default.
• W2605143263 cites W2109730452 @default.
• W2605143263 cites W2112008193 @default.
• W2605143263 cites W2145237733 @default.
• W2605143263 cites W2148177365 @default.
• W2605143263 cites W2152000208 @default.
• W2605143263 cites W2157601642 @default.
• W2605143263 cites W2161771297 @default.
• W2605143263 doi "https://doi.org/10.1177/2045893217705878" @default.
• W2605143263 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5467939" @default.
• W2605143263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28597756" @default.
• W2605143263 hasPublicationYear "2017" @default.
• W2605143263 type Work @default.
• W2605143263 sameAs 2605143263 @default.
• W2605143263 citedByCount "14" @default.
• W2605143263 countsByYear W26051432632017 @default.
• W2605143263 countsByYear W26051432632018 @default.
• W2605143263 countsByYear W26051432632019 @default.
• W2605143263 countsByYear W26051432632021 @default.
• W2605143263 countsByYear W26051432632022 @default.
• W2605143263 crossrefType "journal-article" @default.
• W2605143263 hasAuthorship W2605143263A5044538468 @default.
• W2605143263 hasAuthorship W2605143263A5048505819 @default.
• W2605143263 hasAuthorship W2605143263A5069735529 @default.
• W2605143263 hasAuthorship W2605143263A5084706902 @default.
• W2605143263 hasAuthorship W2605143263A5085718584 @default.
• W2605143263 hasAuthorship W2605143263A5089741245 @default.
• W2605143263 hasAuthorship W2605143263A5090011367 @default.
• W2605143263 hasBestOaLocation W26051432631 @default.
• W2605143263 hasConcept C10162356 @default.
• W2605143263 hasConcept C126322002 @default.
• W2605143263 hasConcept C134018914 @default.
• W2605143263 hasConcept C178790620 @default.
• W2605143263 hasConcept C17991360 @default.
• W2605143263 hasConcept C185592680 @default.
• W2605143263 hasConcept C203014093 @default.
• W2605143263 hasConcept C2776914184 @default.
• W2605143263 hasConcept C2778384902 @default.
• W2605143263 hasConcept C2778690821 @default.
• W2605143263 hasConcept C2778754761 @default.
• W2605143263 hasConcept C2780930700 @default.
• W2605143263 hasConcept C540031477 @default.
• W2605143263 hasConcept C71924100 @default.
• W2605143263 hasConcept C7836513 @default.
• W2605143263 hasConcept C90924648 @default.
• W2605143263 hasConceptScore W2605143263C10162356 @default.
• W2605143263 hasConceptScore W2605143263C126322002 @default.
• W2605143263 hasConceptScore W2605143263C134018914 @default.
• W2605143263 hasConceptScore W2605143263C178790620 @default.
• W2605143263 hasConceptScore W2605143263C17991360 @default.
• W2605143263 hasConceptScore W2605143263C185592680 @default.
• W2605143263 hasConceptScore W2605143263C203014093 @default.
• W2605143263 hasConceptScore W2605143263C2776914184 @default.
• W2605143263 hasConceptScore W2605143263C2778384902 @default.
• W2605143263 hasConceptScore W2605143263C2778690821 @default.
• W2605143263 hasConceptScore W2605143263C2778754761 @default.
• W2605143263 hasConceptScore W2605143263C2780930700 @default.
• W2605143263 hasConceptScore W2605143263C540031477 @default.
• W2605143263 hasConceptScore W2605143263C71924100 @default.
• W2605143263 hasConceptScore W2605143263C7836513 @default.
• W2605143263 hasConceptScore W2605143263C90924648 @default.
• W2605143263 hasFunder F4320334506 @default.
• W2605143263 hasFunder F4320338282 @default.
• W2605143263 hasIssue "2" @default.
• W2605143263 hasLocation W26051432631 @default.
• W2605143263 hasLocation W26051432632 @default.
• W2605143263 hasLocation W26051432633 @default.
• W2605143263 hasLocation W26051432634 @default.
• W2605143263 hasOpenAccess W2605143263 @default.
• W2605143263 hasPrimaryLocation W26051432631 @default.
• W2605143263 hasRelatedWork W1583119428 @default.
• W2605143263 hasRelatedWork W1977918131 @default.
• W2605143263 hasRelatedWork W1990717759 @default.
• W2605143263 hasRelatedWork W2034985166 @default.
• W2605143263 hasRelatedWork W2073275833 @default.
• W2605143263 hasRelatedWork W2075295901 @default.
• W2605143263 hasRelatedWork W2101316595 @default.
• W2605143263 hasRelatedWork W2127733257 @default.
• W2605143263 hasRelatedWork W4254218321 @default.
• W2605143263 hasRelatedWork W563090747 @default.

• next