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• W2605144963 abstract "Significance Renal calcium reabsorption is a critical process for maintaining systemic calcium homeostasis. Although the role of parathyroid hormone (PTH) in the regulation of transcellular Ca 2+ reabsorption in distal convoluted tubules is well understood, its potential role in controlling the paracellular Ca 2+ transport in the thick ascending limb of Henle (TAL) has not been investigated. We now present data demonstrating that PTH/PTHrP receptor (PTH1R) signaling directly and indirectly controls the levels of Claudin14 (CLDN14), a tight-junction protein responsible for paracellular Ca 2+ transport in the TAL. Our findings suggest that down-regulation of Claudin14 could provide a potential treatment option to correct urinary Ca 2+ loss, particularly in patients with hypoparathyroidism." @default.
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• W2605144963 date "2017-04-03" @default.
• W2605144963 modified "2023-09-30" @default.
• W2605144963 title "Parathyroid hormone controls paracellular Ca ²⁺ transport in the thick ascending limb by regulating the tight-junction protein Claudin14" @default.
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• W2605144963 doi "https://doi.org/10.1073/pnas.1616733114" @default.
• W2605144963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5402431" @default.
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• W2605144963 hasPublicationYear "2017" @default.
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