FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605175825> ?p ?o ?g. }

• W2605175825 endingPage "1499" @default.
• W2605175825 startingPage "1489" @default.
• W2605175825 abstract "Abnormal angiogenesis and evasion of apoptosis are hallmarks of cancer. Accordingly, anti-angiogenic and pro-apoptotic therapies are effective strategies for cancer treatment. Medicinal plants, namely, Eugenia jambolana Lam. (Myrtaceae), Musa paradisiaca L. (Musaceae), and Coccinia indica Wight & Arn. (Cucurbitaceae), have not been greatly investigated for their anticancer potential.We investigated the anti-angiogenic and pro-apoptotic efficacy of ethyl acetate (EA) and n-butanol (NB) extracts of E. jambolana (seeds), EA extracts of M. paradisiaca (roots) and C. indica (leaves) with respect to mammary neoplasia.Effect of extracts (2-200 μg/mL) on cytotoxicity and MCF-7, MDA-MB-231 and endothelial cell (EC) proliferation and in vitro angiogenesis were evaluated by MTT, 3[H]thymidine uptake and EC tube formation assays, respectively. In vivo tumour proliferation, VEGF secretion and angiogenesis were assessed using the Ehrlich ascites tumour (EAT) model followed by rat corneal micro-pocket and chicken chorioallantoic membrane (CAM) assays. Apoptosis induction was assessed by morphological and cell cycle analysis.EA extracts of E. jambolana and M. paradisiaca exhibited the highest cytotoxicity (IC50 25 and 60 μg/mL), inhibited cell proliferation (up to 81%), and tube formation (83% and 76%). In vivo treatment reduced body weight (50%); cell number (16.5- and 14.7-fold), secreted VEGF (∼90%), neoangiogenesis in rat cornea (2.5- and 1.5-fold) and CAM (3- and 1.6-fold) besides EAT cells accumulation in sub-G1 phase (20% and 18.38%), respectively.Considering the potent anti-angiogenic and pro-apoptotic properties, lead molecules from EA extracts of E. jambolana and M. paradisiaca can be developed into anticancer drugs." @default.
• W2605175825 created "2017-04-14" @default.
• W2605175825 creator A5034423217 @default.
• W2605175825 creator A5049768801 @default.
• W2605175825 creator A5061432262 @default.
• W2605175825 creator A5081058049 @default.
• W2605175825 date "2017-01-01" @default.
• W2605175825 modified "2023-09-30" @default.
• W2605175825 title "Suppression of VEGF-induced angiogenesis and tumor growth by <i>Eugenia jambolana, Musa paradisiaca,</i> and <i>Coccinia indica</i> extracts" @default.
• W2605175825 cites W1640277972 @default.
• W2605175825 cites W171306473 @default.
• W2605175825 cites W1757407923 @default.
• W2605175825 cites W1961032431 @default.
• W2605175825 cites W1963836015 @default.
• W2605175825 cites W1966173991 @default.
• W2605175825 cites W1970929586 @default.
• W2605175825 cites W1980077962 @default.
• W2605175825 cites W1992112921 @default.
• W2605175825 cites W1995398299 @default.
• W2605175825 cites W1996214125 @default.
• W2605175825 cites W2003298766 @default.
• W2605175825 cites W2003746468 @default.
• W2605175825 cites W2007553857 @default.
• W2605175825 cites W2011398127 @default.
• W2605175825 cites W2022233074 @default.
• W2605175825 cites W2022576539 @default.
• W2605175825 cites W2030104903 @default.
• W2605175825 cites W2032269759 @default.
• W2605175825 cites W2032425910 @default.
• W2605175825 cites W2035089552 @default.
• W2605175825 cites W2040055138 @default.
• W2605175825 cites W2047752458 @default.
• W2605175825 cites W2051393506 @default.
• W2605175825 cites W2053810830 @default.
• W2605175825 cites W2057984123 @default.
• W2605175825 cites W2062195965 @default.
• W2605175825 cites W2062879793 @default.
• W2605175825 cites W2077923814 @default.
• W2605175825 cites W2081199173 @default.
• W2605175825 cites W2082582610 @default.
• W2605175825 cites W2091559840 @default.
• W2605175825 cites W2096465651 @default.
• W2605175825 cites W2108417645 @default.
• W2605175825 cites W2109298525 @default.
• W2605175825 cites W2124729407 @default.
• W2605175825 cites W2130674647 @default.
• W2605175825 cites W2132875781 @default.
• W2605175825 cites W2143926802 @default.
• W2605175825 cites W2152715911 @default.
• W2605175825 cites W2167139020 @default.
• W2605175825 cites W2275566653 @default.
• W2605175825 cites W2298678407 @default.
• W2605175825 cites W2346838716 @default.
• W2605175825 cites W2414136624 @default.
• W2605175825 cites W2580449060 @default.
• W2605175825 cites W4232797145 @default.
• W2605175825 doi "https://doi.org/10.1080/13880209.2017.1307422" @default.
• W2605175825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6130448" @default.
• W2605175825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28367666" @default.
• W2605175825 hasPublicationYear "2017" @default.
• W2605175825 type Work @default.
• W2605175825 sameAs 2605175825 @default.
• W2605175825 citedByCount "18" @default.
• W2605175825 countsByYear W26051758252018 @default.
• W2605175825 countsByYear W26051758252019 @default.
• W2605175825 countsByYear W26051758252020 @default.
• W2605175825 countsByYear W26051758252021 @default.
• W2605175825 countsByYear W26051758252022 @default.
• W2605175825 countsByYear W26051758252023 @default.
• W2605175825 crossrefType "journal-article" @default.
• W2605175825 hasAuthorship W2605175825A5034423217 @default.
• W2605175825 hasAuthorship W2605175825A5049768801 @default.
• W2605175825 hasAuthorship W2605175825A5061432262 @default.
• W2605175825 hasAuthorship W2605175825A5081058049 @default.
• W2605175825 hasBestOaLocation W26051758251 @default.
• W2605175825 hasConcept C109316439 @default.
• W2605175825 hasConcept C150903083 @default.
• W2605175825 hasConcept C190283241 @default.
• W2605175825 hasConcept C202751555 @default.
• W2605175825 hasConcept C207001950 @default.
• W2605175825 hasConcept C2778989076 @default.
• W2605175825 hasConcept C2780394083 @default.
• W2605175825 hasConcept C502942594 @default.
• W2605175825 hasConcept C55493867 @default.
• W2605175825 hasConcept C556039675 @default.
• W2605175825 hasConcept C59822182 @default.
• W2605175825 hasConcept C62112901 @default.
• W2605175825 hasConcept C71924100 @default.
• W2605175825 hasConcept C86803240 @default.
• W2605175825 hasConcept C97230052 @default.
• W2605175825 hasConcept C98274493 @default.
• W2605175825 hasConceptScore W2605175825C109316439 @default.
• W2605175825 hasConceptScore W2605175825C150903083 @default.
• W2605175825 hasConceptScore W2605175825C190283241 @default.
• W2605175825 hasConceptScore W2605175825C202751555 @default.
• W2605175825 hasConceptScore W2605175825C207001950 @default.
• W2605175825 hasConceptScore W2605175825C2778989076 @default.
• W2605175825 hasConceptScore W2605175825C2780394083 @default.

• next