Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605220246> ?p ?o ?g. }
- W2605220246 endingPage "1421" @default.
- W2605220246 startingPage "1413" @default.
- W2605220246 abstract "ABSTRACT Aminopeptidases are ubiquitous hydrolases that cleave the N‐terminal residues of proteins and oligopeptides. They are broadly distributed throughout all kingdoms of life and have been implicated in a wide variety of physiological processes, including viral infection, parasite metabolism, protein processing, regulation of peptide hormones, and cancer cell proliferation. Members of the M1 family, also termed gluzincins, are defined by two highly conserved motifs in the catalytic domain: a zinc‐binding motif, HEXXH‐(X18)‐E; and an exopeptidase motif, GXMEN. We report the high‐resolution X‐ray structures of E. coli aminopeptidase N (PepN) in complex with three aminobenzosuberone scaffolds that display various Ki values (50, 0.33, and 0.034 µ M ) and provide a compelling view of the outstanding selectivity of these chemical entities for the M1 aminopeptidases. This series of inhibitors interacts as transition state mimics with highly conserved residues of the catalytic machinery and substrate recognition sites. Structural comparisons and model‐building studies allowed a deep interpretation of the SAR observed for bacterial, as well as mammalian enzymes. Proteins 2017; 85:1413–1421. © 2017 Wiley Periodicals, Inc." @default.
- W2605220246 created "2017-04-14" @default.
- W2605220246 creator A5010706989 @default.
- W2605220246 creator A5031574561 @default.
- W2605220246 creator A5034051096 @default.
- W2605220246 creator A5035102857 @default.
- W2605220246 creator A5069085736 @default.
- W2605220246 creator A5073753895 @default.
- W2605220246 creator A5073773810 @default.
- W2605220246 date "2017-04-22" @default.
- W2605220246 modified "2023-10-18" @default.
- W2605220246 title "Insight into the remarkable affinity and selectivity of the aminobenzosuberone scaffold for the M1 aminopeptidases family based on structure analysis" @default.
- W2605220246 cites W1535820474 @default.
- W2605220246 cites W1743689021 @default.
- W2605220246 cites W1964276458 @default.
- W2605220246 cites W1980337077 @default.
- W2605220246 cites W1983342808 @default.
- W2605220246 cites W1988072724 @default.
- W2605220246 cites W1988724422 @default.
- W2605220246 cites W1998954104 @default.
- W2605220246 cites W2002115967 @default.
- W2605220246 cites W2005900492 @default.
- W2605220246 cites W2007748264 @default.
- W2605220246 cites W2008525757 @default.
- W2605220246 cites W2009493983 @default.
- W2605220246 cites W2011605939 @default.
- W2605220246 cites W2015236790 @default.
- W2605220246 cites W2020269470 @default.
- W2605220246 cites W2021347039 @default.
- W2605220246 cites W2026106662 @default.
- W2605220246 cites W2043601693 @default.
- W2605220246 cites W2048521920 @default.
- W2605220246 cites W2049115197 @default.
- W2605220246 cites W2054738453 @default.
- W2605220246 cites W2059107251 @default.
- W2605220246 cites W2074473216 @default.
- W2605220246 cites W2092967246 @default.
- W2605220246 cites W2105957252 @default.
- W2605220246 cites W2108921801 @default.
- W2605220246 cites W2110463636 @default.
- W2605220246 cites W2110808180 @default.
- W2605220246 cites W2117569373 @default.
- W2605220246 cites W2122276188 @default.
- W2605220246 cites W2124026197 @default.
- W2605220246 cites W2128704535 @default.
- W2605220246 cites W2144998676 @default.
- W2605220246 cites W2148711203 @default.
- W2605220246 cites W2154714625 @default.
- W2605220246 cites W2158635619 @default.
- W2605220246 cites W2158715838 @default.
- W2605220246 cites W2159171404 @default.
- W2605220246 cites W2160782025 @default.
- W2605220246 cites W2163341755 @default.
- W2605220246 cites W2166344811 @default.
- W2605220246 cites W2167701793 @default.
- W2605220246 cites W2180229411 @default.
- W2605220246 cites W2266013672 @default.
- W2605220246 cites W2316184155 @default.
- W2605220246 cites W4248872320 @default.
- W2605220246 cites W649770388 @default.
- W2605220246 doi "https://doi.org/10.1002/prot.25301" @default.
- W2605220246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28383176" @default.
- W2605220246 hasPublicationYear "2017" @default.
- W2605220246 type Work @default.
- W2605220246 sameAs 2605220246 @default.
- W2605220246 citedByCount "8" @default.
- W2605220246 countsByYear W26052202462018 @default.
- W2605220246 countsByYear W26052202462019 @default.
- W2605220246 countsByYear W26052202462020 @default.
- W2605220246 countsByYear W26052202462022 @default.
- W2605220246 crossrefType "journal-article" @default.
- W2605220246 hasAuthorship W2605220246A5010706989 @default.
- W2605220246 hasAuthorship W2605220246A5031574561 @default.
- W2605220246 hasAuthorship W2605220246A5034051096 @default.
- W2605220246 hasAuthorship W2605220246A5035102857 @default.
- W2605220246 hasAuthorship W2605220246A5069085736 @default.
- W2605220246 hasAuthorship W2605220246A5073753895 @default.
- W2605220246 hasAuthorship W2605220246A5073773810 @default.
- W2605220246 hasConcept C132677234 @default.
- W2605220246 hasConcept C181199279 @default.
- W2605220246 hasConcept C185592680 @default.
- W2605220246 hasConcept C2776580952 @default.
- W2605220246 hasConcept C2780985610 @default.
- W2605220246 hasConcept C515207424 @default.
- W2605220246 hasConcept C53645450 @default.
- W2605220246 hasConcept C54374919 @default.
- W2605220246 hasConcept C55493867 @default.
- W2605220246 hasConcept C62478195 @default.
- W2605220246 hasConcept C70721500 @default.
- W2605220246 hasConcept C86803240 @default.
- W2605220246 hasConceptScore W2605220246C132677234 @default.
- W2605220246 hasConceptScore W2605220246C181199279 @default.
- W2605220246 hasConceptScore W2605220246C185592680 @default.
- W2605220246 hasConceptScore W2605220246C2776580952 @default.
- W2605220246 hasConceptScore W2605220246C2780985610 @default.
- W2605220246 hasConceptScore W2605220246C515207424 @default.
- W2605220246 hasConceptScore W2605220246C53645450 @default.
- W2605220246 hasConceptScore W2605220246C54374919 @default.