FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605251867> ?p ?o ?g. }

• W2605251867 endingPage "1384" @default.
• W2605251867 startingPage "1373" @default.
• W2605251867 abstract "Previous studies have suggested that CD133+ cells isolated from human kidney biopsies have the potential to ameliorate injury following intravenous (IV) administration in rodent models of kidney disease by integrating into damaged renal tissue and generating specialized renal cells. However, whether renal engraftment of CD133+ cells is a prerequisite for ameliorating injury has not yet been unequivocally resolved. Here, we have established a cisplatin-induced nephropathy model in immunodeficient rats to assess the efficacy of CD133+ human kidney cells in restoring renal health, and to determine the fate of these cells after systemic administration. Specifically, following IV administration, we evaluated the impact of the CD133+ cells on renal function by undertaking longitudinal measurements of the glomerular filtration rate using a novel transcutaneous device. Using histological assays, we assessed whether the human kidney cells could promote renal regeneration, and if this was related to their ability to integrate into the damaged kidneys. Our results show that both CD133+ and CD133- cells improve renal function and promote renal regeneration to a similar degree. However, this was not associated with engraftment of the cells into the kidneys. Instead, after IV administration, both cell types were exclusively located in the lungs, and had disappeared by 24 hours. Our data therefore indicate that renal repair is not mediated by CD133+ cells homing to the kidneys and generating specialized renal cells. Instead, renal repair is likely to be mediated by paracrine or endocrine factors. Stem Cells Translational Medicine 2017;6:1373-1384." @default.
• W2605251867 created "2017-04-14" @default.
• W2605251867 creator A5021450710 @default.
• W2605251867 creator A5038477187 @default.
• W2605251867 creator A5041697756 @default.
• W2605251867 creator A5046706740 @default.
• W2605251867 creator A5068548177 @default.
• W2605251867 creator A5072723054 @default.
• W2605251867 creator A5077379694 @default.
• W2605251867 creator A5089790546 @default.
• W2605251867 date "2017-04-04" @default.
• W2605251867 modified "2023-10-13" @default.
• W2605251867 title "Human Kidney-Derived Cells Ameliorate Acute Kidney Injury Without Engrafting into Renal Tissue" @default.
• W2605251867 cites W1513443905 @default.
• W2605251867 cites W1778467727 @default.
• W2605251867 cites W1889901763 @default.
• W2605251867 cites W1970911736 @default.
• W2605251867 cites W1981194657 @default.
• W2605251867 cites W1990363063 @default.
• W2605251867 cites W1999713130 @default.
• W2605251867 cites W2003865749 @default.
• W2605251867 cites W2004650050 @default.
• W2605251867 cites W2015746497 @default.
• W2605251867 cites W2015807591 @default.
• W2605251867 cites W2015953826 @default.
• W2605251867 cites W2016318035 @default.
• W2605251867 cites W2021690806 @default.
• W2605251867 cites W2030909091 @default.
• W2605251867 cites W2032368204 @default.
• W2605251867 cites W2032767299 @default.
• W2605251867 cites W2045847416 @default.
• W2605251867 cites W2047621580 @default.
• W2605251867 cites W2052979682 @default.
• W2605251867 cites W2076593050 @default.
• W2605251867 cites W2077820123 @default.
• W2605251867 cites W2082657187 @default.
• W2605251867 cites W2085204161 @default.
• W2605251867 cites W2086254942 @default.
• W2605251867 cites W2092810335 @default.
• W2605251867 cites W2095082147 @default.
• W2605251867 cites W2097942434 @default.
• W2605251867 cites W2107705756 @default.
• W2605251867 cites W2114698242 @default.
• W2605251867 cites W2114889530 @default.
• W2605251867 cites W2115403023 @default.
• W2605251867 cites W2117048312 @default.
• W2605251867 cites W2117673326 @default.
• W2605251867 cites W2119608540 @default.
• W2605251867 cites W2122677163 @default.
• W2605251867 cites W2129550243 @default.
• W2605251867 cites W2134070522 @default.
• W2605251867 cites W2137854541 @default.
• W2605251867 cites W2140862356 @default.
• W2605251867 cites W2141069547 @default.
• W2605251867 cites W2141720233 @default.
• W2605251867 cites W2147047226 @default.
• W2605251867 cites W2150393481 @default.
• W2605251867 cites W2154215235 @default.
• W2605251867 cites W2154768306 @default.
• W2605251867 cites W2158686528 @default.
• W2605251867 cites W2159726491 @default.
• W2605251867 cites W2163080538 @default.
• W2605251867 cites W2166572577 @default.
• W2605251867 cites W2173934646 @default.
• W2605251867 cites W2178674681 @default.
• W2605251867 cites W2297581 @default.
• W2605251867 cites W2314147905 @default.
• W2605251867 cites W2320383082 @default.
• W2605251867 cites W2325312145 @default.
• W2605251867 cites W2462478200 @default.
• W2605251867 cites W2468168745 @default.
• W2605251867 cites W631915220 @default.
• W2605251867 doi "https://doi.org/10.1002/sctm.16-0352" @default.
• W2605251867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5442715" @default.
• W2605251867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28375556" @default.
• W2605251867 hasPublicationYear "2017" @default.
• W2605251867 type Work @default.
• W2605251867 sameAs 2605251867 @default.
• W2605251867 citedByCount "31" @default.
• W2605251867 countsByYear W26052518672017 @default.
• W2605251867 countsByYear W26052518672018 @default.
• W2605251867 countsByYear W26052518672019 @default.
• W2605251867 countsByYear W26052518672020 @default.
• W2605251867 countsByYear W26052518672021 @default.
• W2605251867 countsByYear W26052518672022 @default.
• W2605251867 countsByYear W26052518672023 @default.
• W2605251867 crossrefType "journal-article" @default.
• W2605251867 hasAuthorship W2605251867A5021450710 @default.
• W2605251867 hasAuthorship W2605251867A5038477187 @default.
• W2605251867 hasAuthorship W2605251867A5041697756 @default.
• W2605251867 hasAuthorship W2605251867A5046706740 @default.
• W2605251867 hasAuthorship W2605251867A5068548177 @default.
• W2605251867 hasAuthorship W2605251867A5072723054 @default.
• W2605251867 hasAuthorship W2605251867A5077379694 @default.
• W2605251867 hasAuthorship W2605251867A5089790546 @default.
• W2605251867 hasBestOaLocation W26052518671 @default.
• W2605251867 hasConcept C126322002 @default.
• W2605251867 hasConcept C134018914 @default.

• next