Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605276630> ?p ?o ?g. }
- W2605276630 endingPage "2307" @default.
- W2605276630 startingPage "2298" @default.
- W2605276630 abstract "Abstract Endothelial progenitor cells ( EPC s) play a capital role in angiogenesis via directly participating in neo‐vessel formation and secreting pro‐angiogenic factors. Stromal cell‐derived factor 1 ( SDF ‐1) and its receptor CXCR 4 play a critical role in the retention and quiescence of EPC s within its niche in the bone marrow. Disturbing the interaction between SDF ‐1 and CXCR 4 is an effective strategy for EPC mobilization. We developed a novel CXCR 4 antagonist P2G, a mutant protein of SDF ‐1β with high antagonistic activity against CXCR 4 and high potency in enhancing ischaemic angiogenesis and blood perfusion. However, its direct effects on ischaemic tissue remain largely unknown. In this study, P2G was found to possess a robust capability to promote EPC infiltration and incorporation in neo‐vessels, enhance the expression and function of pro‐angiogenic factors, such as SDF ‐1, vascular endothelial growth factor and matrix metalloprotein‐9, and activate cell signals involved in angiogenesis, such as proliferating cell nuclear antigen, protein kinase B (Akt), extracellular regulated protein kinases and mammalian target of rapamycin, in ischaemic tissue. Moreover, P2G can attenuate fibrotic remodelling to facilitate the recovery of ischaemic tissue. The capability of P2G in direct augmenting ischaemic environment for angiogenesis suggests that it is a potential candidate for the therapy of ischaemia diseases." @default.
- W2605276630 created "2017-04-14" @default.
- W2605276630 creator A5014656305 @default.
- W2605276630 creator A5017873319 @default.
- W2605276630 creator A5022407487 @default.
- W2605276630 creator A5025077990 @default.
- W2605276630 creator A5026859518 @default.
- W2605276630 creator A5037960195 @default.
- W2605276630 creator A5043696992 @default.
- W2605276630 creator A5048693726 @default.
- W2605276630 creator A5052306100 @default.
- W2605276630 creator A5058791842 @default.
- W2605276630 creator A5088141052 @default.
- W2605276630 date "2017-04-04" @default.
- W2605276630 modified "2023-10-15" @default.
- W2605276630 title "A Novel CXCR4 antagonist enhances angiogenesis<i>via</i>modifying the ischaemic tissue environment" @default.
- W2605276630 cites W1515060166 @default.
- W2605276630 cites W1851300844 @default.
- W2605276630 cites W1966817158 @default.
- W2605276630 cites W1980775727 @default.
- W2605276630 cites W1982861439 @default.
- W2605276630 cites W1989954717 @default.
- W2605276630 cites W1990870979 @default.
- W2605276630 cites W1995159861 @default.
- W2605276630 cites W2004755347 @default.
- W2605276630 cites W2025299174 @default.
- W2605276630 cites W2027677131 @default.
- W2605276630 cites W2037675339 @default.
- W2605276630 cites W2053704719 @default.
- W2605276630 cites W2059373653 @default.
- W2605276630 cites W2066689114 @default.
- W2605276630 cites W2070779780 @default.
- W2605276630 cites W2080196370 @default.
- W2605276630 cites W2080480670 @default.
- W2605276630 cites W2085368741 @default.
- W2605276630 cites W2108875285 @default.
- W2605276630 cites W2111980436 @default.
- W2605276630 cites W2114805956 @default.
- W2605276630 cites W2120223845 @default.
- W2605276630 cites W2121369385 @default.
- W2605276630 cites W2123304597 @default.
- W2605276630 cites W2132075120 @default.
- W2605276630 cites W2141124825 @default.
- W2605276630 cites W2142226770 @default.
- W2605276630 cites W2144210760 @default.
- W2605276630 cites W2144366742 @default.
- W2605276630 cites W2145639716 @default.
- W2605276630 cites W2153224916 @default.
- W2605276630 cites W2153532735 @default.
- W2605276630 cites W2158200096 @default.
- W2605276630 cites W2159913536 @default.
- W2605276630 cites W2161978364 @default.
- W2605276630 cites W2163809998 @default.
- W2605276630 cites W2165225182 @default.
- W2605276630 cites W2165626829 @default.
- W2605276630 cites W2314533647 @default.
- W2605276630 cites W2425790260 @default.
- W2605276630 cites W2560962065 @default.
- W2605276630 doi "https://doi.org/10.1111/jcmm.13150" @default.
- W2605276630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5618675" @default.
- W2605276630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28374486" @default.
- W2605276630 hasPublicationYear "2017" @default.
- W2605276630 type Work @default.
- W2605276630 sameAs 2605276630 @default.
- W2605276630 citedByCount "9" @default.
- W2605276630 countsByYear W26052766302018 @default.
- W2605276630 countsByYear W26052766302019 @default.
- W2605276630 countsByYear W26052766302020 @default.
- W2605276630 countsByYear W26052766302022 @default.
- W2605276630 countsByYear W26052766302023 @default.
- W2605276630 crossrefType "journal-article" @default.
- W2605276630 hasAuthorship W2605276630A5014656305 @default.
- W2605276630 hasAuthorship W2605276630A5017873319 @default.
- W2605276630 hasAuthorship W2605276630A5022407487 @default.
- W2605276630 hasAuthorship W2605276630A5025077990 @default.
- W2605276630 hasAuthorship W2605276630A5026859518 @default.
- W2605276630 hasAuthorship W2605276630A5037960195 @default.
- W2605276630 hasAuthorship W2605276630A5043696992 @default.
- W2605276630 hasAuthorship W2605276630A5048693726 @default.
- W2605276630 hasAuthorship W2605276630A5052306100 @default.
- W2605276630 hasAuthorship W2605276630A5058791842 @default.
- W2605276630 hasAuthorship W2605276630A5088141052 @default.
- W2605276630 hasBestOaLocation W26052766301 @default.
- W2605276630 hasConcept C129470790 @default.
- W2605276630 hasConcept C13373296 @default.
- W2605276630 hasConcept C146285616 @default.
- W2605276630 hasConcept C14858245 @default.
- W2605276630 hasConcept C167734588 @default.
- W2605276630 hasConcept C16930146 @default.
- W2605276630 hasConcept C201750760 @default.
- W2605276630 hasConcept C203014093 @default.
- W2605276630 hasConcept C2776610909 @default.
- W2605276630 hasConcept C2776914184 @default.
- W2605276630 hasConcept C2777025900 @default.
- W2605276630 hasConcept C2778271429 @default.
- W2605276630 hasConcept C2780152582 @default.
- W2605276630 hasConcept C2780394083 @default.
- W2605276630 hasConcept C2781188250 @default.