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• W2605278516 abstract "This study provides the first characterization of early developmental trajectories of corpus callosum (CC) segments in rhesus macaques using noninvasive MRI techniques and assesses long-term effects of neonatal amygdala or hippocampal lesions on CC morphometry. In Experiment 1, 10 monkeys (5 males) were scanned at 1 week-2 years of age; eight additional infants (4 males) were scanned once at 1-4 weeks of age. The first 8 months showed marked growth across all segments, with sustained, albeit slower, growth through 24 months. Males and females had comparable patterns of CC maturation overall, but exhibited slight differences in the anterior and posterior segments, with greater increases in the isthmus for males and greater increases in the rostrum for females. The developmental changes are likely a consequence of varying degrees of axonal myelination, redirection, and pruning. In Experiment 2, animals with neonatal lesions of the amygdala (n = 6; 3 males) or hippocampus (n = 6; 4 males) were scanned at 1.5 years post-surgery and compared to scans of six control animals from Experiment 1. Whereas amygdala damage yielded larger rostral and posterior body segments, hippocampal damage yielded larger rostrum and isthmus. These differences demonstrate that early perturbations to one medial temporal lobe structure may produce extensive and long-lasting repercussions in other brain areas. The current findings emphasize the complexity of neural circuitry putatively subserving neurodevelopmental disorders such as autism spectrum disorder and Williams syndrome, which are each characterized by malformations and dysfunction of complex neural networks that include regions of the medial temporal lobe." @default.
• W2605278516 created "2017-04-14" @default.
• W2605278516 creator A5028073193 @default.
• W2605278516 creator A5042987391 @default.
• W2605278516 creator A5077622614 @default.
• W2605278516 date "2017-04-03" @default.
• W2605278516 modified "2023-10-09" @default.
• W2605278516 title "An MRI study of the corpus callosum in monkeys: Developmental trajectories and effects of neonatal hippocampal and amygdala lesions" @default.
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• W2605278516 doi "https://doi.org/10.1002/dev.21514" @default.
• W2605278516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5421320" @default.
• W2605278516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28369850" @default.
• W2605278516 hasPublicationYear "2017" @default.
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