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- W2605308294 abstract "6533 Background: FDG-PET is increasingly being utilized for response assessment of NHL. The purpose of this study was to determine whether FDG-PET+CT result in a more accurate response classification compared with CT alone in patients with NHL. Methods: FDG-PET and CT were performed in 54 aggressive NHL patients 1–3 months following 4–8 cycles of CHOP-based chemotherapy. 18-month progression-free survival (18-mo PFS) was compared between CT- and PET+CT-assigned response designations, such as complete response (CR), unconfirmed CR (CRu), partial response (PR), stable disease (SD) and progressive disease (PD). Response designations by CT were based on the International Workshop Criteria. PET+CT-based were derived from CT-based designations by integrating the PET findings into those of CT (e.g., patients with CR by CT alone who were positive by PET were classified as PR by PET+CT; those with CRu, PR, or SD by CT who were negative by PET were classified as CR by PET+CT). Results: CT-based response designations were 18CR, 6CRu, 17PR, 12SD and 1PD. PET+CT-based designations were 39CR, 9PR, 5SD, and 1PD. Similar 18-mo PFS was found in patients with CR by PET+CT or CT alone (92% vs. 89%), while there was a statistically significant difference in 18-mo PFS between patients with PR by PET+CT vs. by CT alone (22% vs.70%, P=0.05). Difference in 18-mo PFS between patients with CR and PR by CT was not significant (P=0.3), while difference between CR and PR using PET+CT was highly significant (P<0.0005). Conclusions: Compared with CT-, PET+CT-based response designations more accurately reflect expected outcome in aggressive NHL. These results challenge the current paradigm in response assessment of patients with NHL and suggest that PET/CT-based response classification may become the new standard for NHL. No significant financial relationships to disclose." @default.
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- W2605308294 date "2004-07-15" @default.
- W2605308294 modified "2023-09-27" @default.
- W2605308294 title "Integrated PET based response classification for non-Hodgkin's lymphoma (NHL)" @default.
- W2605308294 doi "https://doi.org/10.1200/jco.2004.22.90140.6533" @default.
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