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- W2605331105 endingPage "59" @default.
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- W2605331105 abstract "New advances in engineering and biomedical technology have enabled recent efforts to capture essential aspects of human physiology in microscale, in-vitro systems. The application of these advances to experimentally model complex processes in an integrated platform — commonly called a ‘human-on-a-chip (HOC)’ — requires that relevant compartments and parameters be sized correctly relative to each other and to the system as a whole. Empirical observation, theoretical treatments of resource distribution systems and natural experiments can all be used to inform rational design of such a system, but technical and fundamental challenges (e.g. small system blood volumes and context-dependent cell metabolism, respectively) pose substantial, unaddressed obstacles. Here, we put forth two fundamental principles for HOC design: inducing in-vivo-like cellular metabolic rates is necessary and may be accomplished in-vitro by limiting O 2 availability and that the effects of increased blood volumes on drug concentration can be mitigated through pharmacokinetics-based treatments of solute distribution. Combining these principles with natural observation and engineering workarounds, we derive a complete set of design criteria for a practically realizable, physiologically faithful, five-organ millionth-scale ([Formula: see text]) microfluidic model of the human body." @default.
- W2605331105 created "2017-04-14" @default.
- W2605331105 creator A5003210434 @default.
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- W2605331105 creator A5017163238 @default.
- W2605331105 creator A5025489981 @default.
- W2605331105 date "2017-03-01" @default.
- W2605331105 modified "2023-09-26" @default.
- W2605331105 title "Building an experimental model of the human body with non-physiological parameters" @default.
- W2605331105 cites W110903188 @default.
- W2605331105 cites W111775996 @default.
- W2605331105 cites W137617671 @default.
- W2605331105 cites W1708314058 @default.
- W2605331105 cites W1848527143 @default.
- W2605331105 cites W1963998078 @default.
- W2605331105 cites W1968919425 @default.
- W2605331105 cites W1978927205 @default.
- W2605331105 cites W1979034422 @default.
- W2605331105 cites W1980275250 @default.
- W2605331105 cites W1981750002 @default.
- W2605331105 cites W1981909768 @default.
- W2605331105 cites W1985452148 @default.
- W2605331105 cites W1991267043 @default.
- W2605331105 cites W1991273988 @default.
- W2605331105 cites W1998220531 @default.
- W2605331105 cites W2001105070 @default.
- W2605331105 cites W2002536707 @default.
- W2605331105 cites W2006914719 @default.
- W2605331105 cites W2008353596 @default.
- W2605331105 cites W2008606045 @default.
- W2605331105 cites W2009706285 @default.
- W2605331105 cites W2010248715 @default.
- W2605331105 cites W2013039658 @default.
- W2605331105 cites W2013520568 @default.
- W2605331105 cites W2013887681 @default.
- W2605331105 cites W2015823673 @default.
- W2605331105 cites W2018516735 @default.
- W2605331105 cites W2020138408 @default.
- W2605331105 cites W2027143209 @default.
- W2605331105 cites W2027872733 @default.
- W2605331105 cites W2029877619 @default.
- W2605331105 cites W2030338281 @default.
- W2605331105 cites W2031281105 @default.
- W2605331105 cites W2032115883 @default.
- W2605331105 cites W2034313730 @default.
- W2605331105 cites W2037564218 @default.
- W2605331105 cites W2037584978 @default.
- W2605331105 cites W2038972234 @default.
- W2605331105 cites W2038998535 @default.
- W2605331105 cites W2042823470 @default.
- W2605331105 cites W2057904754 @default.
- W2605331105 cites W2060768267 @default.
- W2605331105 cites W2062317385 @default.
- W2605331105 cites W2063590950 @default.
- W2605331105 cites W2067841165 @default.
- W2605331105 cites W2073185462 @default.
- W2605331105 cites W2076526734 @default.
- W2605331105 cites W2076901722 @default.
- W2605331105 cites W2076922024 @default.
- W2605331105 cites W2080843536 @default.
- W2605331105 cites W2085435306 @default.
- W2605331105 cites W2085581721 @default.
- W2605331105 cites W2086208936 @default.
- W2605331105 cites W2090136117 @default.
- W2605331105 cites W2092984740 @default.
- W2605331105 cites W2094220307 @default.
- W2605331105 cites W2096114109 @default.
- W2605331105 cites W2097813267 @default.
- W2605331105 cites W2099171717 @default.
- W2605331105 cites W2110850188 @default.
- W2605331105 cites W2111501046 @default.
- W2605331105 cites W2112791462 @default.
- W2605331105 cites W2114416030 @default.
- W2605331105 cites W2116807741 @default.
- W2605331105 cites W2117706379 @default.
- W2605331105 cites W2122927773 @default.
- W2605331105 cites W2129067127 @default.
- W2605331105 cites W2129166877 @default.
- W2605331105 cites W2134377528 @default.
- W2605331105 cites W2136057251 @default.
- W2605331105 cites W2137330513 @default.
- W2605331105 cites W2139424714 @default.
- W2605331105 cites W2141516297 @default.
- W2605331105 cites W2142366069 @default.
- W2605331105 cites W2144610339 @default.
- W2605331105 cites W2163112129 @default.
- W2605331105 cites W2170838454 @default.
- W2605331105 cites W2171803108 @default.
- W2605331105 cites W2174682170 @default.
- W2605331105 cites W2518132040 @default.
- W2605331105 cites W4232189731 @default.
- W2605331105 cites W4238465605 @default.
- W2605331105 cites W4239578492 @default.
- W2605331105 cites W4376542707 @default.
- W2605331105 cites W79067336 @default.
- W2605331105 doi "https://doi.org/10.1142/s2339547817500029" @default.
- W2605331105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5509033" @default.