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- W2605342668 abstract "In this paper, we propose an adaptive randomization design for Phase 2 dose-finding trials to optimize Net Present Value (NPV) for an experimental drug. We replace the traditional fixed sample size design (Patel, et al., 2012) by this new design to see if NPV from the original paper can be improved. Comparison of the proposed design to the previous design is made via simulations using a hypothetical example based on a Diabetic Neuropathic Pain Study." @default.
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- W2605342668 date "2017-06-01" @default.
- W2605342668 modified "2023-09-24" @default.
- W2605342668 title "Optimizing adaptive design for Phase 2 dose-finding trials incorporating long-term success and financial considerations: A case study for neuropathic pain" @default.
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- W2605342668 doi "https://doi.org/10.1016/j.cct.2017.03.011" @default.
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