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• W2605343729 abstract "Organotypic slicing of brain tissue from young rodents has been used as a powerful model system for biomedical research [1Humpel C. Organotypic brain slice cultures: a review.Neuroscience. 2015; 305: 86-98Crossref PubMed Scopus (242) Google Scholar, 2Gähwiler B.H. Capogna M. Debanne D. McKinney R.A. Thompson S.M. Organotypic slice cultures: a technique has come of age.Trends Neurosci. 1997; 20: 471-477Abstract Full Text Full Text PDF PubMed Scopus (734) Google Scholar, 3Stoppini L. Buchs P.A. Muller D. A simple method for organotypic cultures of nervous tissue.J. Neurosci. Methods. 1991; 37: 173-182Crossref PubMed Scopus (2520) Google Scholar]. Organotypic slicing complements cell culture and in vivo studies in multiple facets. This system can be useful for investigating manipulation of cellular signaling pathways without the hindrance of the blood-brain barrier while sacrificing fewer animals in the process. It also allows for preserved cellular connectivity and local intact circuitry which is a drawback of isolated cell cultures. Studies on age-related diseases have mainly used embryonic or early postnatal organotypic slice tissue. Excluding synaptic plasticity studies that are usually carried-out over a few hours and use adult mice or rats, a handful of studies performed on adult animals have had success for survival of slices [4Mewes A. et al.Organotypic brain slice cultures of adult transgenic P301S mice—a model for tauopathy studies.PLoS One. 2012; 7: e45017Crossref PubMed Scopus (47) Google Scholar, 5Kim H. Kim E. Park M. Lee E. Namkoong K. Organotypic hippocampal slice culture from the adult mouse brain: a versatile tool for translational neuropsychopharmacology.Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 2013; 41: 36-43Crossref PubMed Scopus (51) Google Scholar]. Here we describe a method for culturing organotypic slices with high viability from hippocampus of aged mice and rabbits.•Our method permits slices from mice as old as 16 months and rabbits as old as years of age to survive ex vivo up to 8 weeks [6Schrag M. Sharma S. Brown-Borg H. Ghribi O. Hippocampus of Ames dwarf mice is resistant to β-amyloid-induced tau hyperphosphorylation and changes in apoptosis-regulatory protein levels.Hippocampus. 2008; 18: 239-244Crossref PubMed Scopus (33) Google Scholar, 7Marwarha G. Prasanthi J.R. Schommer J. Dasari B. Ghribi O. Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus.Mol. Neurodegener. 2011; 6PubMed Google Scholar, 8Marwarha G. Dasari B. Prasanthi J.R.P. Schommer J. Ghribi O. Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.J. Alzheimers Dis. 2010; 19: 1007-1019Crossref PubMed Scopus (110) Google Scholar, 9Prasanthi J.R.P. Larson T. Schommer J. Ghribi O. Silencing GADD153/CHOP gene expression protects against Alzheimer’s disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.PLoS One. 2011; 6: e26420Crossref PubMed Scopus (65) Google Scholar]. Such a slice system may be relevant to investigating age-related brain diseases." @default.
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• W2605343729 date "2017-01-01" @default.
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• W2605343729 title "Method for organotypic tissue culture in the aged animal" @default.
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• W2605343729 doi "https://doi.org/10.1016/j.mex.2017.03.003" @default.
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