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- W2605346087 abstract "In 1906, Alzheimer described the clinical and neuropathological characteristics of the disease that was subsequently named after him. Although the paired helical filament was identified as the major component of the neurofibrillary pathology of Alzheimer's disease in 1963, its molecular composition was only uncovered in the 1980s. In 1988, work at the MRC Laboratory of Molecular Biology in Cambridge (UK) provided direct proof that tau protein is an integral component of the paired helical filament. The paper highlighted here [Goedert M., Wischik C.M., Crowther R.A., Walker J.E. and Klug A. (1988) Cloning and sequencing of a core protein of the paired helical filament of Alzheimer disease: Identification as the microtubule-associated protein tau. Proc. Natl. Acad. Sci. USA 85, 4051–4055] also reported the first sequerce of a human tau isoform and paved the way for the identification of the six brain tau isoforms that are expressed by alternative mRNA splicing from a single gene. By the early 1990s, it was clear that tau protein is the major component of the paired helical filament and that the latter is made of all six tau isoforms, each full-length and hyperphosphorylated." @default.
- W2605346087 created "2017-04-14" @default.
- W2605346087 creator A5030636499 @default.
- W2605346087 creator A5037379608 @default.
- W2605346087 creator A5044619533 @default.
- W2605346087 date "2006-07-27" @default.
- W2605346087 modified "2023-09-28" @default.
- W2605346087 title "Tau protein, the paired helical filament and Alzheimer's disease" @default.
- W2605346087 cites W1217317373 @default.
- W2605346087 cites W1481130297 @default.
- W2605346087 cites W1509571186 @default.
- W2605346087 cites W150987474 @default.
- W2605346087 cites W1511517753 @default.
- W2605346087 cites W1557500714 @default.
- W2605346087 cites W1587065131 @default.
- W2605346087 cites W1590773131 @default.
- W2605346087 cites W1598318710 @default.
- W2605346087 cites W1604814851 @default.
- W2605346087 cites W1605328378 @default.
- W2605346087 cites W1607830031 @default.
- W2605346087 cites W1611407165 @default.
- W2605346087 cites W1621042331 @default.
- W2605346087 cites W1758831574 @default.
- W2605346087 cites W1791072074 @default.
- W2605346087 cites W1863222819 @default.
- W2605346087 cites W1929269608 @default.
- W2605346087 cites W1958842451 @default.
- W2605346087 cites W1965232330 @default.
- W2605346087 cites W1967000235 @default.
- W2605346087 cites W1967285029 @default.
- W2605346087 cites W1968641736 @default.
- W2605346087 cites W1971541898 @default.
- W2605346087 cites W1972355725 @default.
- W2605346087 cites W1973774127 @default.
- W2605346087 cites W1973855353 @default.
- W2605346087 cites W1974760231 @default.
- W2605346087 cites W1975536870 @default.
- W2605346087 cites W1978668412 @default.
- W2605346087 cites W1980389635 @default.
- W2605346087 cites W1981050556 @default.
- W2605346087 cites W1983010354 @default.
- W2605346087 cites W1983769449 @default.
- W2605346087 cites W1983988051 @default.
- W2605346087 cites W1985090720 @default.
- W2605346087 cites W1987046654 @default.
- W2605346087 cites W1992589625 @default.
- W2605346087 cites W1994282166 @default.
- W2605346087 cites W1995515835 @default.
- W2605346087 cites W1995562130 @default.
- W2605346087 cites W1998307422 @default.
- W2605346087 cites W2001443225 @default.
- W2605346087 cites W2004901932 @default.
- W2605346087 cites W2007313489 @default.
- W2605346087 cites W2009218913 @default.
- W2605346087 cites W2012781495 @default.
- W2605346087 cites W2013475161 @default.
- W2605346087 cites W2014504341 @default.
- W2605346087 cites W2016877136 @default.
- W2605346087 cites W2016986190 @default.
- W2605346087 cites W2018908557 @default.
- W2605346087 cites W2024363942 @default.
- W2605346087 cites W2026263038 @default.
- W2605346087 cites W2026771024 @default.
- W2605346087 cites W2028410287 @default.
- W2605346087 cites W2029543048 @default.
- W2605346087 cites W2036745486 @default.
- W2605346087 cites W2036755018 @default.
- W2605346087 cites W2040351396 @default.
- W2605346087 cites W2043661712 @default.
- W2605346087 cites W2045153164 @default.
- W2605346087 cites W2045220210 @default.
- W2605346087 cites W2046209489 @default.
- W2605346087 cites W2046436217 @default.
- W2605346087 cites W2046720254 @default.
- W2605346087 cites W2048677944 @default.
- W2605346087 cites W2049354825 @default.
- W2605346087 cites W2051896853 @default.
- W2605346087 cites W2052742260 @default.
- W2605346087 cites W2053116497 @default.
- W2605346087 cites W2057323230 @default.
- W2605346087 cites W2057682957 @default.
- W2605346087 cites W2058723245 @default.
- W2605346087 cites W2060458492 @default.
- W2605346087 cites W2062531332 @default.
- W2605346087 cites W2064494790 @default.
- W2605346087 cites W2070494722 @default.
- W2605346087 cites W2073128231 @default.
- W2605346087 cites W2078658743 @default.
- W2605346087 cites W2078666749 @default.
- W2605346087 cites W2083633251 @default.
- W2605346087 cites W2089331767 @default.
- W2605346087 cites W2091305524 @default.
- W2605346087 cites W2095180840 @default.
- W2605346087 cites W2095578806 @default.
- W2605346087 cites W2111567107 @default.
- W2605346087 cites W2115015599 @default.
- W2605346087 cites W2116068118 @default.
- W2605346087 cites W2120843434 @default.