Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605348059> ?p ?o ?g. }
- W2605348059 endingPage "418" @default.
- W2605348059 startingPage "409" @default.
- W2605348059 abstract "Background: PTPN22 plays a crucial role in regulating the function of various cells of the immune system, particularly T cells. Polymorphisms of the PTPN22 gene have been associated with many autoimmune diseases, including type 1 diabetes (T1D) which is a T-cell-mediated disease.Objective: The present study was aimed at genotyping of an Iranian population for five polymorphisms of the PTPN22 gene.Methods: The study population consisted of 99 T1D patients and 100 healthy controls. We genotyped five single-nucleotide polymorphisms (SNPs) (rs12760457, rs1310182, rs1217414, rs33996649, and rs2476601) of the PTPN22 gene.Results: Regarding the variant rs2476601, genotypes AG and GG were increased and decreased in T1D patients compared with controls, respectively. Further, alleles G and A of this SNP were found to be decreased and increased in T1D patients, respectively (p value = 0.001). However, T1D and control groups did not differ on genotype distribution or allele frequency for other investigated SNPs.Conclusions: The PTPN22 rs2476601 minor allele (A) was associated with T1D in Iran, accounting for its pathophysiology in autoimmune diseases." @default.
- W2605348059 created "2017-04-14" @default.
- W2605348059 creator A5014591284 @default.
- W2605348059 creator A5028354492 @default.
- W2605348059 creator A5043512353 @default.
- W2605348059 creator A5043958551 @default.
- W2605348059 creator A5055093325 @default.
- W2605348059 creator A5056573984 @default.
- W2605348059 creator A5056899761 @default.
- W2605348059 creator A5077112779 @default.
- W2605348059 creator A5080185559 @default.
- W2605348059 date "2017-04-04" @default.
- W2605348059 modified "2023-10-16" @default.
- W2605348059 title "<i>PTPN22</i> Single-Nucleotide Polymorphisms in Iranian Patients with Type 1 Diabetes Mellitus" @default.
- W2605348059 cites W1752045965 @default.
- W2605348059 cites W1975225648 @default.
- W2605348059 cites W1976192764 @default.
- W2605348059 cites W1979055784 @default.
- W2605348059 cites W1985467451 @default.
- W2605348059 cites W1988025806 @default.
- W2605348059 cites W1990420620 @default.
- W2605348059 cites W1994402720 @default.
- W2605348059 cites W2000007641 @default.
- W2605348059 cites W2001295992 @default.
- W2605348059 cites W2007685911 @default.
- W2605348059 cites W2008649874 @default.
- W2605348059 cites W2009729495 @default.
- W2605348059 cites W2011450045 @default.
- W2605348059 cites W2014077667 @default.
- W2605348059 cites W2016319058 @default.
- W2605348059 cites W2019063639 @default.
- W2605348059 cites W2020958278 @default.
- W2605348059 cites W2024108088 @default.
- W2605348059 cites W2024670158 @default.
- W2605348059 cites W2025027233 @default.
- W2605348059 cites W2027736618 @default.
- W2605348059 cites W2037458138 @default.
- W2605348059 cites W2041391173 @default.
- W2605348059 cites W2046225888 @default.
- W2605348059 cites W2046383867 @default.
- W2605348059 cites W2051253865 @default.
- W2605348059 cites W2054459142 @default.
- W2605348059 cites W2055971070 @default.
- W2605348059 cites W2061819326 @default.
- W2605348059 cites W2067395718 @default.
- W2605348059 cites W2067942096 @default.
- W2605348059 cites W2074891952 @default.
- W2605348059 cites W2076819781 @default.
- W2605348059 cites W2083190035 @default.
- W2605348059 cites W2083826829 @default.
- W2605348059 cites W2095720372 @default.
- W2605348059 cites W2099882936 @default.
- W2605348059 cites W2101324880 @default.
- W2605348059 cites W2101865039 @default.
- W2605348059 cites W2103769722 @default.
- W2605348059 cites W2105030240 @default.
- W2605348059 cites W2107254797 @default.
- W2605348059 cites W2107295258 @default.
- W2605348059 cites W2118225901 @default.
- W2605348059 cites W2123721436 @default.
- W2605348059 cites W2124204679 @default.
- W2605348059 cites W2127372143 @default.
- W2605348059 cites W2129387684 @default.
- W2605348059 cites W2130445686 @default.
- W2605348059 cites W2132478002 @default.
- W2605348059 cites W2132691537 @default.
- W2605348059 cites W2139645781 @default.
- W2605348059 cites W2142155452 @default.
- W2605348059 cites W2145170767 @default.
- W2605348059 cites W2159053368 @default.
- W2605348059 cites W2161978035 @default.
- W2605348059 cites W2164354285 @default.
- W2605348059 cites W2169349361 @default.
- W2605348059 doi "https://doi.org/10.1080/08820139.2017.1288239" @default.
- W2605348059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28375784" @default.
- W2605348059 hasPublicationYear "2017" @default.
- W2605348059 type Work @default.
- W2605348059 sameAs 2605348059 @default.
- W2605348059 citedByCount "10" @default.
- W2605348059 countsByYear W26053480592017 @default.
- W2605348059 countsByYear W26053480592018 @default.
- W2605348059 countsByYear W26053480592019 @default.
- W2605348059 countsByYear W26053480592021 @default.
- W2605348059 countsByYear W26053480592022 @default.
- W2605348059 countsByYear W26053480592023 @default.
- W2605348059 crossrefType "journal-article" @default.
- W2605348059 hasAuthorship W2605348059A5014591284 @default.
- W2605348059 hasAuthorship W2605348059A5028354492 @default.
- W2605348059 hasAuthorship W2605348059A5043512353 @default.
- W2605348059 hasAuthorship W2605348059A5043958551 @default.
- W2605348059 hasAuthorship W2605348059A5055093325 @default.
- W2605348059 hasAuthorship W2605348059A5056573984 @default.
- W2605348059 hasAuthorship W2605348059A5056899761 @default.
- W2605348059 hasAuthorship W2605348059A5077112779 @default.
- W2605348059 hasAuthorship W2605348059A5080185559 @default.
- W2605348059 hasConcept C104317684 @default.
- W2605348059 hasConcept C126322002 @default.
- W2605348059 hasConcept C134018914 @default.