Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605370362> ?p ?o ?g. }
- W2605370362 abstract "ABSTRACT Clostridium perfringens encodes at least two different quorum sensing (QS) systems, the Agr-like and LuxS, and recent studies have highlighted their importance in the regulation of toxin production and virulence. The role of QS in the pathogenesis of necrotic enteritis (NE) in poultry and the regulation of NetB, the key toxin involved, has not yet been investigated. We have generated isogenic agrB -null and complemented strains from parent strain CP1 and demonstrated that the virulence of the agrB -null mutant was strongly attenuated in a chicken NE model system and restored by complementation. The production of NetB, a key NE-associated toxin, was dramatically reduced in the agrB mutant at both the transcriptional and protein levels, though not in a luxS mutant. Transwell assays confirmed that the Agr-like QS system controls NetB production through a diffusible signal. Global gene expression analysis of the agrB mutant identified additional genes modulated by Agr-like QS, including operons related to phospholipid metabolism and adherence, which may also play a role in NE pathogenesis. This study provides the first evidence that the Agr-like QS system is critical for NE pathogenesis and identifies a number of Agr-regulated genes, most notably netB , that are potentially involved in mediating its effects. The Agr-like QS system thus may serve as a target for developing novel interventions to prevent NE in chickens." @default.
- W2605370362 created "2017-04-14" @default.
- W2605370362 creator A5009770102 @default.
- W2605370362 creator A5021364942 @default.
- W2605370362 creator A5022984104 @default.
- W2605370362 creator A5048550248 @default.
- W2605370362 creator A5051610166 @default.
- W2605370362 creator A5061162754 @default.
- W2605370362 creator A5061163756 @default.
- W2605370362 creator A5076120454 @default.
- W2605370362 creator A5078348179 @default.
- W2605370362 creator A5078764103 @default.
- W2605370362 creator A5089447139 @default.
- W2605370362 date "2017-06-01" @default.
- W2605370362 modified "2023-10-16" @default.
- W2605370362 title "The Agr-Like Quorum Sensing System Is Required for Pathogenesis of Necrotic Enteritis Caused by Clostridium perfringens in Poultry" @default.
- W2605370362 cites W1565552396 @default.
- W2605370362 cites W1829531435 @default.
- W2605370362 cites W1981562300 @default.
- W2605370362 cites W1983592682 @default.
- W2605370362 cites W1984831953 @default.
- W2605370362 cites W1989213972 @default.
- W2605370362 cites W1990347601 @default.
- W2605370362 cites W1991414612 @default.
- W2605370362 cites W1994462493 @default.
- W2605370362 cites W1999225385 @default.
- W2605370362 cites W2008758799 @default.
- W2605370362 cites W2020310520 @default.
- W2605370362 cites W2042622308 @default.
- W2605370362 cites W2044396650 @default.
- W2605370362 cites W2045142223 @default.
- W2605370362 cites W2055873811 @default.
- W2605370362 cites W2059548608 @default.
- W2605370362 cites W2064860971 @default.
- W2605370362 cites W2068273643 @default.
- W2605370362 cites W2075429432 @default.
- W2605370362 cites W2076243547 @default.
- W2605370362 cites W2081157135 @default.
- W2605370362 cites W2085694731 @default.
- W2605370362 cites W2088822458 @default.
- W2605370362 cites W2093049777 @default.
- W2605370362 cites W2096230220 @default.
- W2605370362 cites W2098167705 @default.
- W2605370362 cites W2098866570 @default.
- W2605370362 cites W2099792326 @default.
- W2605370362 cites W2100370202 @default.
- W2605370362 cites W2101222303 @default.
- W2605370362 cites W2102320488 @default.
- W2605370362 cites W2103559686 @default.
- W2605370362 cites W2105013839 @default.
- W2605370362 cites W2107277218 @default.
- W2605370362 cites W2111326608 @default.
- W2605370362 cites W2113388925 @default.
- W2605370362 cites W2114738204 @default.
- W2605370362 cites W2116205144 @default.
- W2605370362 cites W2129027970 @default.
- W2605370362 cites W2131055772 @default.
- W2605370362 cites W2133857956 @default.
- W2605370362 cites W2136855427 @default.
- W2605370362 cites W2141569031 @default.
- W2605370362 cites W2142135460 @default.
- W2605370362 cites W2151238732 @default.
- W2605370362 cites W2157795344 @default.
- W2605370362 cites W2159823628 @default.
- W2605370362 cites W2167591869 @default.
- W2605370362 cites W2192080449 @default.
- W2605370362 cites W2298565575 @default.
- W2605370362 cites W2335761568 @default.
- W2605370362 cites W2466489494 @default.
- W2605370362 cites W2508318076 @default.
- W2605370362 cites W4246645615 @default.
- W2605370362 cites W4294107304 @default.
- W2605370362 cites W956392526 @default.
- W2605370362 doi "https://doi.org/10.1128/iai.00975-16" @default.
- W2605370362 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5442616" @default.
- W2605370362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28373356" @default.
- W2605370362 hasPublicationYear "2017" @default.
- W2605370362 type Work @default.
- W2605370362 sameAs 2605370362 @default.
- W2605370362 citedByCount "36" @default.
- W2605370362 countsByYear W26053703622017 @default.
- W2605370362 countsByYear W26053703622018 @default.
- W2605370362 countsByYear W26053703622019 @default.
- W2605370362 countsByYear W26053703622020 @default.
- W2605370362 countsByYear W26053703622021 @default.
- W2605370362 countsByYear W26053703622022 @default.
- W2605370362 countsByYear W26053703622023 @default.
- W2605370362 crossrefType "journal-article" @default.
- W2605370362 hasAuthorship W2605370362A5009770102 @default.
- W2605370362 hasAuthorship W2605370362A5021364942 @default.
- W2605370362 hasAuthorship W2605370362A5022984104 @default.
- W2605370362 hasAuthorship W2605370362A5048550248 @default.
- W2605370362 hasAuthorship W2605370362A5051610166 @default.
- W2605370362 hasAuthorship W2605370362A5061162754 @default.
- W2605370362 hasAuthorship W2605370362A5061163756 @default.
- W2605370362 hasAuthorship W2605370362A5076120454 @default.
- W2605370362 hasAuthorship W2605370362A5078348179 @default.
- W2605370362 hasAuthorship W2605370362A5078764103 @default.
- W2605370362 hasAuthorship W2605370362A5089447139 @default.
- W2605370362 hasBestOaLocation W26053703621 @default.