Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605397483> ?p ?o ?g. }
- W2605397483 endingPage "859" @default.
- W2605397483 startingPage "859" @default.
- W2605397483 abstract "Ghrelin is a hormone predominantly produced in and secreted from the stomach. Ghrelin is involved in many physiological processes including feeding, the stress response, and in modulating learning, memory and motivational processes. Ghrelin does this by binding to its receptor, the growth hormone secretagogue receptor (GHSR), a receptor found in relatively high concentrations in hypothalamic and mesolimbic brain regions. While the feeding and metabolic effects of ghrelin can be explained by the effects of this hormone on regions of the brain that have a more permeable blood brain barrier (BBB), ghrelin produced within the periphery demonstrates a limited ability to reach extrahypothalamic regions where GHSRs are expressed. Therefore, one of the most pressing unanswered questions plaguing ghrelin research is how GHSRs, distributed in brain regions protected by the BBB, are activated despite ghrelin’s predominant peripheral production and poor ability to transverse the BBB. This manuscript will describe how peripheral ghrelin activates central GHSRs to encourage feeding, and how central ghrelin synthesis and ghrelin independent activation of GHSRs may also contribute to the modulation of feeding behaviours." @default.
- W2605397483 created "2017-04-28" @default.
- W2605397483 creator A5033172966 @default.
- W2605397483 creator A5038294948 @default.
- W2605397483 date "2017-04-19" @default.
- W2605397483 modified "2023-10-02" @default.
- W2605397483 title "Clarifying the Ghrelin System’s Ability to Regulate Feeding Behaviours Despite Enigmatic Spatial Separation of the GHSR and Its Endogenous Ligand" @default.
- W2605397483 cites W1488596761 @default.
- W2605397483 cites W1499189927 @default.
- W2605397483 cites W1506453366 @default.
- W2605397483 cites W1525267985 @default.
- W2605397483 cites W1537882803 @default.
- W2605397483 cites W1542237172 @default.
- W2605397483 cites W1552965236 @default.
- W2605397483 cites W1561443084 @default.
- W2605397483 cites W1562038312 @default.
- W2605397483 cites W1565433182 @default.
- W2605397483 cites W1572502886 @default.
- W2605397483 cites W1594223323 @default.
- W2605397483 cites W1596010380 @default.
- W2605397483 cites W1599926903 @default.
- W2605397483 cites W1607480655 @default.
- W2605397483 cites W1616806865 @default.
- W2605397483 cites W1796054280 @default.
- W2605397483 cites W1871710146 @default.
- W2605397483 cites W1915088265 @default.
- W2605397483 cites W1925492557 @default.
- W2605397483 cites W1941456052 @default.
- W2605397483 cites W1963755841 @default.
- W2605397483 cites W1963829188 @default.
- W2605397483 cites W1964081706 @default.
- W2605397483 cites W1965780343 @default.
- W2605397483 cites W1966594035 @default.
- W2605397483 cites W1967779656 @default.
- W2605397483 cites W1968518710 @default.
- W2605397483 cites W1968942700 @default.
- W2605397483 cites W1969330145 @default.
- W2605397483 cites W1969835310 @default.
- W2605397483 cites W1970697913 @default.
- W2605397483 cites W1970886138 @default.
- W2605397483 cites W1971713759 @default.
- W2605397483 cites W1972476379 @default.
- W2605397483 cites W1972953707 @default.
- W2605397483 cites W1973839604 @default.
- W2605397483 cites W1973955359 @default.
- W2605397483 cites W1975327379 @default.
- W2605397483 cites W1975642877 @default.
- W2605397483 cites W1976623136 @default.
- W2605397483 cites W1977173967 @default.
- W2605397483 cites W1977940746 @default.
- W2605397483 cites W1978245181 @default.
- W2605397483 cites W1978612017 @default.
- W2605397483 cites W1978808714 @default.
- W2605397483 cites W1979212195 @default.
- W2605397483 cites W1980127660 @default.
- W2605397483 cites W1980218797 @default.
- W2605397483 cites W1981250920 @default.
- W2605397483 cites W1981479562 @default.
- W2605397483 cites W1981927821 @default.
- W2605397483 cites W1982392568 @default.
- W2605397483 cites W1983602021 @default.
- W2605397483 cites W1983881786 @default.
- W2605397483 cites W1983953944 @default.
- W2605397483 cites W1984260452 @default.
- W2605397483 cites W1984885846 @default.
- W2605397483 cites W1985071684 @default.
- W2605397483 cites W1987555746 @default.
- W2605397483 cites W1988347665 @default.
- W2605397483 cites W1990095603 @default.
- W2605397483 cites W1990689226 @default.
- W2605397483 cites W1991015425 @default.
- W2605397483 cites W1991141677 @default.
- W2605397483 cites W1991334367 @default.
- W2605397483 cites W1991974510 @default.
- W2605397483 cites W1992019774 @default.
- W2605397483 cites W1992304191 @default.
- W2605397483 cites W1993478320 @default.
- W2605397483 cites W1993990935 @default.
- W2605397483 cites W1994949063 @default.
- W2605397483 cites W1995327253 @default.
- W2605397483 cites W1995734405 @default.
- W2605397483 cites W1996184082 @default.
- W2605397483 cites W1996284417 @default.
- W2605397483 cites W1996650491 @default.
- W2605397483 cites W1996710832 @default.
- W2605397483 cites W1996761434 @default.
- W2605397483 cites W1996822329 @default.
- W2605397483 cites W1997494318 @default.
- W2605397483 cites W1999123071 @default.
- W2605397483 cites W2002263339 @default.
- W2605397483 cites W2002561597 @default.
- W2605397483 cites W2003321861 @default.
- W2605397483 cites W2003545653 @default.
- W2605397483 cites W2003982930 @default.
- W2605397483 cites W2005057377 @default.
- W2605397483 cites W2005155278 @default.
- W2605397483 cites W2005168887 @default.
- W2605397483 cites W2007389940 @default.