FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605400261> ?p ?o ?g. }

• W2605400261 abstract "Resistance to anti-malarial drugs hinders efforts on malaria elimination and eradication. Following the global spread of chloroquine-resistant parasites, the Republic of Congo adopted artemisinin-based combination therapy (ACT) in 2006 as a first-line treatment for uncomplicated malaria. To assess the impacts after implementation of ACT, a molecular surveillance for anti-malarial drug resistance was conducted in Congo 4 and 9 years after the introduction of ACT. Blood samples of 431 febrile children aged 1–10 years were utilized from two previous studies conducted in 2010 (N = 311) and 2015 (N = 120). All samples were screened for malaria parasites using nested PCR. Direct sequencing was used to determine the frequency distribution of genetic variants in the anti-malarial drug-resistant Plasmodium falciparum genes (Pfcrt, Pfmdr1, Pfatp6, Pfk13) in malaria-positive isolates. One-hundred and nineteen (N = 70 from 2010 and N = 49 from 2015) samples were positive for P. falciparum. A relative decrease in the proportion of chloroquine-resistant haplotype (CVIET) from 100% in 2005, 1 year before the introduction and implementation of ACT in 2006, to 98% in 2010 to 71% in 2015 was observed. Regarding the multidrug transporter gene, a considerable reduction in the frequency of the mutations N86Y (from 73 to 27%) and D1246Y (from 22 to 0%) was observed. However, the prevalence of the Y184F mutation remained stable (49% in 2010 compared to 54% in 2015). Isolates carrying the Pfatp6 H243Y was 25% in 2010 and this frequency was reduced to null in 2015. None of the parasites harboured the Pfk13 mutations associated with prolonged artemisinin clearance in Southeast Asia. Nevertheless, 13 new Pfk13 variants are reported among the investigated isolates. The implementation of ACT has led to the decline in prevalence of chloroquine-resistant parasites in the Republic of Congo. However, the constant prevalence of the PfMDR1 Y184F mutation, associated with lumefantrine susceptibility, indicate a selective drug pressure still exists. Taken together, this study could serve as the basis for epidemiological studies monitoring the distribution of molecular markers of artemisinin resistance in the Republic of Congo." @default.
• W2605400261 created "2017-04-28" @default.
• W2605400261 creator A5015402262 @default.
• W2605400261 creator A5019744263 @default.
• W2605400261 creator A5030700484 @default.
• W2605400261 creator A5048408740 @default.
• W2605400261 creator A5058290833 @default.
• W2605400261 creator A5064904760 @default.
• W2605400261 creator A5078633270 @default.
• W2605400261 creator A5079241432 @default.
• W2605400261 date "2017-04-19" @default.
• W2605400261 modified "2023-10-15" @default.
• W2605400261 title "Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy" @default.
• W2605400261 cites W1646238694 @default.
• W2605400261 cites W1769148934 @default.
• W2605400261 cites W1950804392 @default.
• W2605400261 cites W1988279280 @default.
• W2605400261 cites W1994373940 @default.
• W2605400261 cites W2005682005 @default.
• W2605400261 cites W2008166606 @default.
• W2605400261 cites W2009722550 @default.
• W2605400261 cites W2019105064 @default.
• W2605400261 cites W2025054505 @default.
• W2605400261 cites W2025943007 @default.
• W2605400261 cites W2033721665 @default.
• W2605400261 cites W2048271518 @default.
• W2605400261 cites W2056979654 @default.
• W2605400261 cites W2066069334 @default.
• W2605400261 cites W2075453057 @default.
• W2605400261 cites W2083522771 @default.
• W2605400261 cites W2103132311 @default.
• W2605400261 cites W2104361833 @default.
• W2605400261 cites W2104700616 @default.
• W2605400261 cites W2117304502 @default.
• W2605400261 cites W2124634096 @default.
• W2605400261 cites W2125397010 @default.
• W2605400261 cites W2129965217 @default.
• W2605400261 cites W2131902613 @default.
• W2605400261 cites W2132831164 @default.
• W2605400261 cites W2142060065 @default.
• W2605400261 cites W2145852091 @default.
• W2605400261 cites W2149311205 @default.
• W2605400261 cites W2150269854 @default.
• W2605400261 cites W2155148069 @default.
• W2605400261 cites W2156225399 @default.
• W2605400261 cites W2163576684 @default.
• W2605400261 cites W2205470162 @default.
• W2605400261 cites W2234933177 @default.
• W2605400261 cites W2315257982 @default.
• W2605400261 cites W2397788564 @default.
• W2605400261 cites W2473953134 @default.
• W2605400261 cites W2524789376 @default.
• W2605400261 cites W2563671002 @default.
• W2605400261 doi "https://doi.org/10.1186/s12936-017-1816-x" @default.
• W2605400261 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5395861" @default.
• W2605400261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28420403" @default.
• W2605400261 hasPublicationYear "2017" @default.
• W2605400261 type Work @default.
• W2605400261 sameAs 2605400261 @default.
• W2605400261 citedByCount "23" @default.
• W2605400261 countsByYear W26054002612017 @default.
• W2605400261 countsByYear W26054002612018 @default.
• W2605400261 countsByYear W26054002612019 @default.
• W2605400261 countsByYear W26054002612020 @default.
• W2605400261 countsByYear W26054002612021 @default.
• W2605400261 countsByYear W26054002612022 @default.
• W2605400261 countsByYear W26054002612023 @default.
• W2605400261 crossrefType "journal-article" @default.
• W2605400261 hasAuthorship W2605400261A5015402262 @default.
• W2605400261 hasAuthorship W2605400261A5019744263 @default.
• W2605400261 hasAuthorship W2605400261A5030700484 @default.
• W2605400261 hasAuthorship W2605400261A5048408740 @default.
• W2605400261 hasAuthorship W2605400261A5058290833 @default.
• W2605400261 hasAuthorship W2605400261A5064904760 @default.
• W2605400261 hasAuthorship W2605400261A5078633270 @default.
• W2605400261 hasAuthorship W2605400261A5079241432 @default.
• W2605400261 hasBestOaLocation W26054002611 @default.
• W2605400261 hasConcept C114851261 @default.
• W2605400261 hasConcept C126322002 @default.
• W2605400261 hasConcept C138816342 @default.
• W2605400261 hasConcept C142724271 @default.
• W2605400261 hasConcept C159047783 @default.
• W2605400261 hasConcept C185032368 @default.
• W2605400261 hasConcept C190612196 @default.
• W2605400261 hasConcept C203014093 @default.
• W2605400261 hasConcept C2776120307 @default.
• W2605400261 hasConcept C2777425658 @default.
• W2605400261 hasConcept C2778048844 @default.
• W2605400261 hasConcept C2778371730 @default.
• W2605400261 hasConcept C2780035454 @default.
• W2605400261 hasConcept C500440147 @default.
• W2605400261 hasConcept C71924100 @default.
• W2605400261 hasConcept C86803240 @default.
• W2605400261 hasConcept C89423630 @default.
• W2605400261 hasConcept C98274493 @default.
• W2605400261 hasConceptScore W2605400261C114851261 @default.
• W2605400261 hasConceptScore W2605400261C126322002 @default.
• W2605400261 hasConceptScore W2605400261C138816342 @default.
• W2605400261 hasConceptScore W2605400261C142724271 @default.
• W2605400261 hasConceptScore W2605400261C159047783 @default.

• next