Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605411934> ?p ?o ?g. }
- W2605411934 abstract "The immune system focuses on and responds to very few representative immunodominant epitopes from pathogenic insults. However, due to the complexity of the antigen processing, understanding the parameters that lead to immunodominance has proved difficult. In an attempt to uncover the determinants of immunodominance among several dominant epitopes, we utilized a cell free antigen processing system and allowed the system to identify the hierarchies among potential determinants. We then tested the results in vivo; in mice and in human. We report here, that immunodominance of known sequences in a given protein can change if two or more proteins are being processed and presented simultaneously. Surprisingly, we find that new spacer/tag sequences commonly added to proteins for purification purposes can distort the capture of the physiological immunodominant epitopes. We warn against adding tags and spacers to candidate vaccines, or recommend cleaving it off before using for vaccination." @default.
- W2605411934 created "2017-04-28" @default.
- W2605411934 creator A5009023489 @default.
- W2605411934 creator A5011134045 @default.
- W2605411934 creator A5015933395 @default.
- W2605411934 creator A5041527259 @default.
- W2605411934 creator A5057205976 @default.
- W2605411934 date "2017-04-19" @default.
- W2605411934 modified "2023-09-26" @default.
- W2605411934 title "Distorted Immunodominance by Linker Sequences or other Epitopes from a Second Protein Antigen During Antigen-Processing" @default.
- W2605411934 cites W1056381329 @default.
- W2605411934 cites W1586085788 @default.
- W2605411934 cites W1680217275 @default.
- W2605411934 cites W1700891670 @default.
- W2605411934 cites W1976844387 @default.
- W2605411934 cites W1983355123 @default.
- W2605411934 cites W1985725780 @default.
- W2605411934 cites W1985859196 @default.
- W2605411934 cites W1988869609 @default.
- W2605411934 cites W1989757089 @default.
- W2605411934 cites W1992438598 @default.
- W2605411934 cites W1994136017 @default.
- W2605411934 cites W2007153980 @default.
- W2605411934 cites W2012952808 @default.
- W2605411934 cites W2015865604 @default.
- W2605411934 cites W2016677174 @default.
- W2605411934 cites W2017936764 @default.
- W2605411934 cites W2023038954 @default.
- W2605411934 cites W2026142529 @default.
- W2605411934 cites W2033994868 @default.
- W2605411934 cites W2045209342 @default.
- W2605411934 cites W2051539436 @default.
- W2605411934 cites W2055330678 @default.
- W2605411934 cites W2056651081 @default.
- W2605411934 cites W2067288485 @default.
- W2605411934 cites W2067878569 @default.
- W2605411934 cites W2079561588 @default.
- W2605411934 cites W2086418273 @default.
- W2605411934 cites W2089759681 @default.
- W2605411934 cites W2090342749 @default.
- W2605411934 cites W2090433023 @default.
- W2605411934 cites W2092363477 @default.
- W2605411934 cites W2099584100 @default.
- W2605411934 cites W2102135396 @default.
- W2605411934 cites W2107177722 @default.
- W2605411934 cites W2118358914 @default.
- W2605411934 cites W2124701722 @default.
- W2605411934 cites W2125745098 @default.
- W2605411934 cites W2134364025 @default.
- W2605411934 cites W2135275485 @default.
- W2605411934 cites W2138517340 @default.
- W2605411934 cites W2148767879 @default.
- W2605411934 cites W2152659018 @default.
- W2605411934 cites W2156268117 @default.
- W2605411934 cites W2159254336 @default.
- W2605411934 cites W2162205486 @default.
- W2605411934 cites W2163074720 @default.
- W2605411934 cites W2163357710 @default.
- W2605411934 cites W2163660675 @default.
- W2605411934 cites W2164778558 @default.
- W2605411934 cites W2401721120 @default.
- W2605411934 cites W2402566725 @default.
- W2605411934 cites W2417225767 @default.
- W2605411934 cites W2528265709 @default.
- W2605411934 doi "https://doi.org/10.1038/srep46418" @default.
- W2605411934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5396073" @default.
- W2605411934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28422163" @default.
- W2605411934 hasPublicationYear "2017" @default.
- W2605411934 type Work @default.
- W2605411934 sameAs 2605411934 @default.
- W2605411934 citedByCount "9" @default.
- W2605411934 countsByYear W26054119342018 @default.
- W2605411934 countsByYear W26054119342019 @default.
- W2605411934 countsByYear W26054119342021 @default.
- W2605411934 countsByYear W26054119342022 @default.
- W2605411934 countsByYear W26054119342023 @default.
- W2605411934 crossrefType "journal-article" @default.
- W2605411934 hasAuthorship W2605411934A5009023489 @default.
- W2605411934 hasAuthorship W2605411934A5011134045 @default.
- W2605411934 hasAuthorship W2605411934A5015933395 @default.
- W2605411934 hasAuthorship W2605411934A5041527259 @default.
- W2605411934 hasAuthorship W2605411934A5057205976 @default.
- W2605411934 hasBestOaLocation W26054119341 @default.
- W2605411934 hasConcept C147483822 @default.
- W2605411934 hasConcept C159047783 @default.
- W2605411934 hasConcept C195616568 @default.
- W2605411934 hasConcept C203014093 @default.
- W2605411934 hasConcept C2776525413 @default.
- W2605411934 hasConcept C70721500 @default.
- W2605411934 hasConcept C86803240 @default.
- W2605411934 hasConceptScore W2605411934C147483822 @default.
- W2605411934 hasConceptScore W2605411934C159047783 @default.
- W2605411934 hasConceptScore W2605411934C195616568 @default.
- W2605411934 hasConceptScore W2605411934C203014093 @default.
- W2605411934 hasConceptScore W2605411934C2776525413 @default.
- W2605411934 hasConceptScore W2605411934C70721500 @default.
- W2605411934 hasConceptScore W2605411934C86803240 @default.
- W2605411934 hasIssue "1" @default.
- W2605411934 hasLocation W26054119341 @default.
- W2605411934 hasLocation W26054119342 @default.