Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605415016> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2605415016 abstract "Primary plasma cell leukemia (pPCL) is a rare and aggressive plasma cell neoplasm, with rapid clinical course. In this study, we evaluated the treatment status and survival outcomes of Korean patients with pPCL. Seventy patients were diagnosed with pPCL between February 1998 and December 2015. The median age of the patients was 63.5 years (range, 34-85). Most of patients (70.0%) had International Staging System III.Conventional karyotyping was assessed in 47 patients and FISH analysis was performed in 43 patients. Abnormal karyotype was detected in 34 patients (72.3%). The most common abnormalities were complex karyotype (65.9%). Hypodiploidy, del (13q14), del (17p13), and t(11;14) were found16 (34%), 14 (29%), 12 (25%), and 11 (23%) patients, respectively. Amongthe 70 patients, 60 patients were treated.Thirty-six patients were initially treated with novel agents and 12 received novel-containing regimens as salvage therapy. Twelve patients received conventional chemotherapies only. Twenty-two patients underwent high dose chemotherapy and autologous stem cell transplantation (HDT/ASCT), and one received the allogeneic stem cell transplantation. After a median follow-up of 16.5 months, overall survival (OS) was 16.1 months (95% CI, 11.7-20.8). Twenty patients (33.3%) died within less than one year following the diagnosis, and the early mortality rate was lower in patients who were initially treated with novel agents (22.2% vs. 50.0%, p = 0.049). The median OS of three treatment groups comprising conventional chemotherapy only, novel agents only, and novel agents + HDT/ASCT were 2.9, 12.3, and 31.1 months, respectively (P=0.001). Patients who achieved complete response (CR)after initial therapy had significantly improved OS than did others (36.4 vs. 14.1 months, P 5.5 mg/dl (HR 3.218, 95% CI 1.011-10.238, P = 0.048)were significantly associated with survival outcomes. In young patients (age Disclosures No relevant conflicts of interest to declare." @default.
- W2605415016 created "2017-04-28" @default.
- W2605415016 creator A5011061382 @default.
- W2605415016 creator A5012675709 @default.
- W2605415016 creator A5014597278 @default.
- W2605415016 creator A5022259689 @default.
- W2605415016 creator A5023660159 @default.
- W2605415016 creator A5027919726 @default.
- W2605415016 creator A5028088359 @default.
- W2605415016 creator A5038188064 @default.
- W2605415016 creator A5041723605 @default.
- W2605415016 creator A5041899046 @default.
- W2605415016 creator A5041987846 @default.
- W2605415016 creator A5044268319 @default.
- W2605415016 creator A5044958787 @default.
- W2605415016 creator A5045264210 @default.
- W2605415016 creator A5054573839 @default.
- W2605415016 creator A5068837815 @default.
- W2605415016 creator A5077318648 @default.
- W2605415016 creator A5081706948 @default.
- W2605415016 creator A5087021923 @default.
- W2605415016 creator A5088824120 @default.
- W2605415016 date "2017-02-01" @default.
- W2605415016 modified "2023-10-08" @default.
- W2605415016 title "The outcomes of Korean Patients With Primary Plasma Cell Leukemia: Analysis of Korean Multiple Myeloma Working Party (KMM160)" @default.
- W2605415016 doi "https://doi.org/10.1016/j.clml.2017.03.067" @default.
- W2605415016 hasPublicationYear "2017" @default.
- W2605415016 type Work @default.
- W2605415016 sameAs 2605415016 @default.
- W2605415016 citedByCount "0" @default.
- W2605415016 crossrefType "journal-article" @default.
- W2605415016 hasAuthorship W2605415016A5011061382 @default.
- W2605415016 hasAuthorship W2605415016A5012675709 @default.
- W2605415016 hasAuthorship W2605415016A5014597278 @default.
- W2605415016 hasAuthorship W2605415016A5022259689 @default.
- W2605415016 hasAuthorship W2605415016A5023660159 @default.
- W2605415016 hasAuthorship W2605415016A5027919726 @default.
- W2605415016 hasAuthorship W2605415016A5028088359 @default.
- W2605415016 hasAuthorship W2605415016A5038188064 @default.
- W2605415016 hasAuthorship W2605415016A5041723605 @default.
- W2605415016 hasAuthorship W2605415016A5041899046 @default.
- W2605415016 hasAuthorship W2605415016A5041987846 @default.
- W2605415016 hasAuthorship W2605415016A5044268319 @default.
- W2605415016 hasAuthorship W2605415016A5044958787 @default.
- W2605415016 hasAuthorship W2605415016A5045264210 @default.
- W2605415016 hasAuthorship W2605415016A5054573839 @default.
- W2605415016 hasAuthorship W2605415016A5068837815 @default.
- W2605415016 hasAuthorship W2605415016A5077318648 @default.
- W2605415016 hasAuthorship W2605415016A5081706948 @default.
- W2605415016 hasAuthorship W2605415016A5087021923 @default.
- W2605415016 hasAuthorship W2605415016A5088824120 @default.
- W2605415016 hasConcept C126322002 @default.
- W2605415016 hasConcept C141071460 @default.
- W2605415016 hasConcept C143998085 @default.
- W2605415016 hasConcept C2776364478 @default.
- W2605415016 hasConcept C2776694085 @default.
- W2605415016 hasConcept C2779050716 @default.
- W2605415016 hasConcept C2780353925 @default.
- W2605415016 hasConcept C2911091166 @default.
- W2605415016 hasConcept C3018657049 @default.
- W2605415016 hasConcept C71924100 @default.
- W2605415016 hasConcept C90924648 @default.
- W2605415016 hasConceptScore W2605415016C126322002 @default.
- W2605415016 hasConceptScore W2605415016C141071460 @default.
- W2605415016 hasConceptScore W2605415016C143998085 @default.
- W2605415016 hasConceptScore W2605415016C2776364478 @default.
- W2605415016 hasConceptScore W2605415016C2776694085 @default.
- W2605415016 hasConceptScore W2605415016C2779050716 @default.
- W2605415016 hasConceptScore W2605415016C2780353925 @default.
- W2605415016 hasConceptScore W2605415016C2911091166 @default.
- W2605415016 hasConceptScore W2605415016C3018657049 @default.
- W2605415016 hasConceptScore W2605415016C71924100 @default.
- W2605415016 hasConceptScore W2605415016C90924648 @default.
- W2605415016 hasLocation W26054150161 @default.
- W2605415016 hasOpenAccess W2605415016 @default.
- W2605415016 hasPrimaryLocation W26054150161 @default.
- W2605415016 hasRelatedWork W1966418556 @default.
- W2605415016 hasRelatedWork W2115945349 @default.
- W2605415016 hasRelatedWork W2241382955 @default.
- W2605415016 hasRelatedWork W2537689434 @default.
- W2605415016 hasRelatedWork W2538114067 @default.
- W2605415016 hasRelatedWork W2554498638 @default.
- W2605415016 hasRelatedWork W2557235450 @default.
- W2605415016 hasRelatedWork W2558456719 @default.
- W2605415016 hasRelatedWork W2558854175 @default.
- W2605415016 hasRelatedWork W2560182095 @default.
- W2605415016 hasRelatedWork W2567594949 @default.
- W2605415016 hasRelatedWork W2574300986 @default.
- W2605415016 hasRelatedWork W2588142421 @default.
- W2605415016 hasRelatedWork W2595367007 @default.
- W2605415016 hasRelatedWork W2783594926 @default.
- W2605415016 hasRelatedWork W2979796411 @default.
- W2605415016 hasRelatedWork W2987787412 @default.
- W2605415016 hasRelatedWork W3175594385 @default.
- W2605415016 hasRelatedWork W3196771116 @default.
- W2605415016 hasRelatedWork W3214714318 @default.
- W2605415016 isParatext "false" @default.
- W2605415016 isRetracted "false" @default.
- W2605415016 magId "2605415016" @default.
- W2605415016 workType "article" @default.