FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2605420255> ?p ?o ?g. }

• W2605420255 endingPage "1062" @default.
• W2605420255 startingPage "1054" @default.
• W2605420255 abstract "Nonadherence to prescribed dosing regimens is a significant problem in the treatment of pediatric and adult chronic epilepsy, and can result in severe consequences to patient outcomes. In this first-of-kind preclinical study, the impact of nonadherence on seizure control was studied by simulating human patterns of nonadherence in an animal epilepsy model.In study 1, three different patterns of nonadherence were modeled in newly diagnosed epileptic rats treated with carbamazepine: perfect adherence (100% of pellets contained carbamazepine), variable nonadherence (50% of pellets contained carbamazepine with different dosing patterns between animals), and complete nonadherence (0% of pellets contained carbamazepine). In study 2, a cohort of newly diagnosed epileptic rats were subjected to a drug holiday nonadherence paradigm, that is, a 2-week on (100%), 2-week off (0%), and 2-week on (100%) carbamazepine paradigm.In the first experiment, the 100% (0.3 ± 0.2 SD convulsive seizures per day) adherent cohort demonstrated better seizure control than either the 0% (1.1 ± 0.8 SD) or 50% (0.8 ± 0.6 SD) adherent cohorts, which had similar levels of seizure control. In the second study, poor seizure control was exhibited during the second 2 weeks; that is, the drug holiday epoch; however, this did not negatively affect restoration of seizure control upon reinstatement of CBZ.The results from this pilot investigation suggest that nonadherence to carbamazepine is associated with significant negative but reversible effects on seizure control in an animal model of epilepsy. Furthermore, these results demonstrate that animal studies of nonadherence can yield potentially important and translatable insights into the consequences of nonadherence on seizure control." @default.
• W2605420255 created "2017-04-28" @default.
• W2605420255 creator A5002880520 @default.
• W2605420255 creator A5041189287 @default.
• W2605420255 creator A5071489205 @default.
• W2605420255 creator A5078584329 @default.
• W2605420255 creator A5088706930 @default.
• W2605420255 date "2017-04-12" @default.
• W2605420255 modified "2023-10-17" @default.
• W2605420255 title "The impact of nonadherence to antiseizure drugs on seizure outcomes in an animal model of epilepsy" @default.
• W2605420255 cites W1539414530 @default.
• W2605420255 cites W1552531538 @default.
• W2605420255 cites W1865292948 @default.
• W2605420255 cites W2013877697 @default.
• W2605420255 cites W2022637923 @default.
• W2605420255 cites W2025437989 @default.
• W2605420255 cites W2028410743 @default.
• W2605420255 cites W2038680426 @default.
• W2605420255 cites W2042428840 @default.
• W2605420255 cites W2042526236 @default.
• W2605420255 cites W2048355456 @default.
• W2605420255 cites W2049095305 @default.
• W2605420255 cites W2051854790 @default.
• W2605420255 cites W2053816089 @default.
• W2605420255 cites W2057230367 @default.
• W2605420255 cites W2059223526 @default.
• W2605420255 cites W2073528283 @default.
• W2605420255 cites W2081563870 @default.
• W2605420255 cites W2084410352 @default.
• W2605420255 cites W2091244418 @default.
• W2605420255 cites W2100862552 @default.
• W2605420255 cites W2103946141 @default.
• W2605420255 cites W2107472322 @default.
• W2605420255 cites W2141750721 @default.
• W2605420255 cites W2143232901 @default.
• W2605420255 cites W2149187403 @default.
• W2605420255 cites W2164573587 @default.
• W2605420255 cites W2167309854 @default.
• W2605420255 cites W2167457703 @default.
• W2605420255 cites W4251642169 @default.
• W2605420255 doi "https://doi.org/10.1111/epi.13742" @default.
• W2605420255 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28401980" @default.
• W2605420255 hasPublicationYear "2017" @default.
• W2605420255 type Work @default.
• W2605420255 sameAs 2605420255 @default.
• W2605420255 citedByCount "20" @default.
• W2605420255 countsByYear W26054202552017 @default.
• W2605420255 countsByYear W26054202552018 @default.
• W2605420255 countsByYear W26054202552019 @default.
• W2605420255 countsByYear W26054202552020 @default.
• W2605420255 countsByYear W26054202552021 @default.
• W2605420255 countsByYear W26054202552023 @default.
• W2605420255 crossrefType "journal-article" @default.
• W2605420255 hasAuthorship W2605420255A5002880520 @default.
• W2605420255 hasAuthorship W2605420255A5041189287 @default.
• W2605420255 hasAuthorship W2605420255A5071489205 @default.
• W2605420255 hasAuthorship W2605420255A5078584329 @default.
• W2605420255 hasAuthorship W2605420255A5088706930 @default.
• W2605420255 hasBestOaLocation W26054202551 @default.
• W2605420255 hasConcept C118552586 @default.
• W2605420255 hasConcept C126322002 @default.
• W2605420255 hasConcept C187212893 @default.
• W2605420255 hasConcept C2775858608 @default.
• W2605420255 hasConcept C2777288759 @default.
• W2605420255 hasConcept C2778186239 @default.
• W2605420255 hasConcept C2779253243 @default.
• W2605420255 hasConcept C2910833928 @default.
• W2605420255 hasConcept C42219234 @default.
• W2605420255 hasConcept C71924100 @default.
• W2605420255 hasConcept C72563966 @default.
• W2605420255 hasConceptScore W2605420255C118552586 @default.
• W2605420255 hasConceptScore W2605420255C126322002 @default.
• W2605420255 hasConceptScore W2605420255C187212893 @default.
• W2605420255 hasConceptScore W2605420255C2775858608 @default.
• W2605420255 hasConceptScore W2605420255C2777288759 @default.
• W2605420255 hasConceptScore W2605420255C2778186239 @default.
• W2605420255 hasConceptScore W2605420255C2779253243 @default.
• W2605420255 hasConceptScore W2605420255C2910833928 @default.
• W2605420255 hasConceptScore W2605420255C42219234 @default.
• W2605420255 hasConceptScore W2605420255C71924100 @default.
• W2605420255 hasConceptScore W2605420255C72563966 @default.
• W2605420255 hasFunder F4320332161 @default.
• W2605420255 hasFunder F4320337359 @default.
• W2605420255 hasIssue "6" @default.
• W2605420255 hasLocation W26054202551 @default.
• W2605420255 hasLocation W26054202552 @default.
• W2605420255 hasOpenAccess W2605420255 @default.
• W2605420255 hasPrimaryLocation W26054202551 @default.
• W2605420255 hasRelatedWork W1969760382 @default.
• W2605420255 hasRelatedWork W1970780326 @default.
• W2605420255 hasRelatedWork W2066519361 @default.
• W2605420255 hasRelatedWork W2072053288 @default.
• W2605420255 hasRelatedWork W2086998976 @default.
• W2605420255 hasRelatedWork W2153335219 @default.
• W2605420255 hasRelatedWork W2429723649 @default.
• W2605420255 hasRelatedWork W2745017859 @default.
• W2605420255 hasRelatedWork W2906906539 @default.
• W2605420255 hasRelatedWork W3043448346 @default.

• next